Bioorganometallics 2005
DOI: 10.1002/3527607692.ch1
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A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles

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Cited by 28 publications
(20 citation statements)
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References 171 publications
(215 reference statements)
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“…[46] In contrast, bio-organometallic chemistry is a more recent, but now burgeoning, field in which organometallic moieties are incorporated into biologically active molecules. [47] The term was apparently first used in 1985 to describe molecules containing metal carbonyl fragments pbonded to an aromatic ring of a steroid, as in (estradiol)Cr(CO) 3 . [48] The idea was to use the natural hormone, in this case estradiol, to transport a label to, and thereby assay, the receptor sites by measuring the intensity of the very strong metal carbonyl, u CO , infrared vibrations between 2100 and 1850 cm À1 ; this frequency range is compatible with a window in which the proteins do not absorb.…”
Section: Cyclophanes In Bio-organometallic Chemistrymentioning
confidence: 99%
“…[46] In contrast, bio-organometallic chemistry is a more recent, but now burgeoning, field in which organometallic moieties are incorporated into biologically active molecules. [47] The term was apparently first used in 1985 to describe molecules containing metal carbonyl fragments pbonded to an aromatic ring of a steroid, as in (estradiol)Cr(CO) 3 . [48] The idea was to use the natural hormone, in this case estradiol, to transport a label to, and thereby assay, the receptor sites by measuring the intensity of the very strong metal carbonyl, u CO , infrared vibrations between 2100 and 1850 cm À1 ; this frequency range is compatible with a window in which the proteins do not absorb.…”
Section: Cyclophanes In Bio-organometallic Chemistrymentioning
confidence: 99%
“…On top of that, some transition metal complexes are required to be handled with care due to their air-and moisture-sensitivity and toxicity issues. Nevertheless, there are also many classes of transition metal complexes that are sufficiently stable in air and water, and employable in biological systems [9,10]. In fact, some of them have been successfully translated to clinical uses.…”
Section: Introductionmentioning
confidence: 99%
“…Although it was less toxic, containing only 19% arsenic [2] , neoarsphenamine was nonetheless associated with side-effects such as nausea and vomiting. An additional problem was that both Salvarsan and Neosalvarsan had to be stored in sealed vials under a nitrogen atmosphere to prevent oxidation [26] .…”
Section: Salvarsan the First Successful Chemotherapeutic Drugmentioning
confidence: 99%