People all over the world are deeply aware of the importance of good health by the epidemic in recent years, which has caused tremendous attention on health monitoring industry and technology. Sensors are widely used in the health monitoring field. However, traditional sensors are mainly rigid devices, which are not suitable for human health monitoring. Flexible sensors are gradually available, but most of the processes are complex and the cost is high, which seriously restricts their rapid development. In this paper, a simple design of flexible sensors based on reduced graphene oxide (RGO) was proposed, which can be used for real-time health monitoring. The performance investigations of flexible sensors were conducted and the results indicate that the response time of the flexible force sensor is 540 ms and the relaxation time is 330 ms. It is highly sensitive to pressure load, solution concentration and vibration signal. The humidity sensor based on RGO is sensitive to the surrounding humidity by sensing water molecules adsorbed on the sensor surface. The flexible sensors fabricated by the method proposed in this paper require simple process and exhibit high performance. Hereby, they have broad application prospect in the field of health monitoring.