A novel free-standing nanowire substrate with surface enhanced Raman scattering (SERS) activity

Bayata, Fatma; Akinci, Zehra; Donatan, A. Senem; Ürgen, Mustafa

doi:10.1016/j.matlet.2011.10.015

Cited by 14 publications

(16 citation statements)

References 12 publications

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“…However, results reveal that nickel nanowires synthesized by electrochemical process are Raman insensitive because of the inherent characteristics of nickel. Interestingly, gold coated nickel nanowires fabricated by the same method are noted to be Raman active 152 . In this research, we developed a nano-biosensor using a functionalized hybrid nickel nanonetwork for Commercially available Nickel 200 sheets (3 mm thickness) having 99% nickel were used in all experiments.…”

Section: Introductionmentioning

confidence: 97%

“…The nickel nanostructures acted as a carrier of the gold nanoparticle and a platform to attract and adhere biomolecules, and they in no way assisted in actively inducing Raman scattering. Thus, these highly anisotropic nanomaterials fabricated using solution-based methods are dependent on the use of noble metal coatings such gold and silver to accomplish SERS enhancement at 532 and 785 nm152 . Hence, there is a significant incentive to fill the need of SERS active nickel-based nanostructures, which will further the development of optical-based detection nanobiosensor platforms and reduce the reliance on noble metals as SERS activators.…”

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confidence: 99%

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Hybridizing nickel platform using ultra-short pulsed laser: a new paradigm towards biomedical sensing and theranostics

Vijayakumar¹

2021

Preprint

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A self-assembled 3D nanonetwork of Nickel and Nickel Oxide is synthesized by ultrashort pulsed laser through multiphoton ionization. The synthesized nanonetwork with tunable physiochemical property was investigated for cancer therapeutic and biomolecular sensing applications. In this thesis, the developed 3D nickel nanomatrix effectively regulated HeLa cancer cell adhesion and proliferation mimicking Extracellular Matrix (ECM). This behaviour explicitly demonstrated that the initial incubation period was devoted to baiting fibroblast and HeLa cells to proliferate upon the nanomatrix and subsequently the same nanomatrix exhibited cell trapping behaviour upon HeLa cells after an increased incubation period thereby controlling proliferation. The results brought new insight as to how HeLa cells behaved differently when compared to NIH3T3 fibroblast cells opening pioneering application in drug-free cancer therapy. To delve deeper into nickel nanonetwork for cancer therapy the laser ionization was manipulated to induce two distinct quantum theranosomes. Presently, quantum materials are limited due to 0D & 1D materials lacking biocompatibility resulting in coated materials with labelled tags for fluorescence excitation. The theranosomes mimicked tumor microenvironment by selectively accelerating the proliferation of mammalian fibroblasts cells while inducing cancer therapy. Furthermore, the theranosomes opened up label-free bioimaging probe for differentiating (HeLa & MDAMB-231) from mammalian fibroblast cells for cancer diagnostics. In-addition to label-free bioimaging, the development of an ultrasensitive biosensor for targeted biomolecule sensing was developed addressing the drawback faced with fluorescence imaging using Surface Enhanced Raman Scattering (SERS). We developed a SERS active nano-biosensor to detect chemical dye Crystal Violet (CV) and biomolecule glutathione(GSH). The Raman detection of crystal violet (CV) and glutathione (GSH) molecules was noted with 1 pM (1×10-12M) concentrations at (532 & 785nm) excitation wavelengths with an enhancement factor of 109, not been observed even in plasmonic materials. This extends the limit of detection (LOD), confirming suitability for chemical and biomolecular sensing. Additionally, the quantum confinement effect will result in an ultrasensitive sensor diagnosing and differentiating cancer cells from fibroblast cells. Based on the results in this thesis, the multifunctional feasibility of nano and quantum scale nickel structures arranged in 3D assembly for its direct application in cancer therapeutics, encompassing cancer bioimaging and diagnostics.

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Section: Introductionmentioning

confidence: 97%

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confidence: 99%

Hybridizing nickel platform using ultra-short pulsed laser: a new paradigm towards biomedical sensing and theranostics

Vijayakumar¹

2021

Preprint

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“…SERS substrates have been fabricated ranging from rough metal surfaces to fractals, nanowires and well-ordered substrates. [9][10][11][12] The plasmonic nanostructures required for the SERS are commonly in the form of solid substrates (on glass or Si wafer) or as colloidal solutions. 12,13 However, the solid substrates are rigid and brittle and hence, these static substrates severely limit the application of plasmonic nanostructures, such as to detect the biomarkers directly on human skin.…”

Section: Introductionmentioning

confidence: 99%

Proposal for a gel-based SERS sensor

Kumar¹,

Namura

Suzuki

2019

Plasmonics in Biology and Medicine XVI

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The plasmonic nanostructures required for the SERS are commonly in the form of solid substrates, or as colloidal solutions, both of them are not very useful to detect the biomarkers directly on human skins. Gel-based SERS substrates, into which the plasmonic nanostructures are incorporated, will be helpful for the direct collection of the biomarkers from secretions such as sweat. To elucidate these points, we studied the diffusion of Raman probe 4, 4'-Bipyridine (BPY) in the cetyltrimethylammonium bromide:sodium salicylate (CTAB:NaSal) gel. Au nano-island SERS chip was coated with a 1:1 complex of CTAB:NaSal. Then, the diffusion of the probe was studied by SERS spectra as a function of time. The SERS signal intensity increases gradually with increasing time. Highly porous gel rapidly absorbed aqueous analyte solutions generating large SERS signals. The subsequent increase in signal could arise from the diffusion of the analyte molecule into the gel and onto the Au aggregates. Importantly, this gel-based SERS sensor did not significantly compromise the SERS performance of the analyte. We propose that this gel-based SERS sensor can be smeared directly onto the skin surface to absorb the body fluids from sweat, enabling the detection of biomarkers.

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“…[16][17][18] There are also few reports on the literatures on PDMS based SERS substrates. [19][20][21] Although, SERS has emerged as a potential technique for chemical and biological sensing but it has few limitations like all the others techniques.…”

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confidence: 99%

A facile method for fabrication of buckled PDMS silver nanorod arrays as active 3D SERS cages for bacterial sensing

et al. 2015

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A novel free-standing nanowire substrate with surface enhanced Raman scattering (SERS) activity

Cited by 14 publications

References 12 publications

Hybridizing nickel platform using ultra-short pulsed laser: a new paradigm towards biomedical sensing and theranostics

Hybridizing nickel platform using ultra-short pulsed laser: a new paradigm towards biomedical sensing and theranostics

Proposal for a gel-based SERS sensor

A facile method for fabrication of buckled PDMS silver nanorod arrays as active 3D SERS cages for bacterial sensing

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