A novel function for a micro RNA: Negative regulators can do positive for the hepatitis C virus

Appel, Nicole; Bartenschlager, Ralf

doi:10.1002/hep.21092

Cited by 10 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, miRNA may regulate differentiation and maintenance of cell identity in the hematopoietic system (7,8), contribute to establishing muscle phenotypes (9), control morphogenesis of epithelial tissues (10), and regulate aspects of organogenesis (11,12) and metabolic processes (13,14). These structures may also be important in innate immune responses that control viral infections by blocking the synthesis of viral proteins (15). Viral genomes also encode miRNAs and these seem to evolve rapidly, and regulate both the viral life-cycle and the interaction between viruses and their hosts (16).…”

Section: Clinical Relevancementioning

confidence: 99%

Regulation of MicroRNA by Antagomirs

Mattes

Yang

Foster

2007

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

The discovery of small "noncoding" or "nonmessenger" RNA molecules that are repressors of translation (microRNAs) has provided the opportunity to specifically suppress a gene or clusters of genes. Moreover, the recent employment of synthetic analogs of these small RNA molecules termed "antagomirs" has shown that microRNAs of interest can be specifically targeted. Understanding the role of microRNAs in fundamental processes associated with complex diseases such as asthma, chronic obstructive pulmonary disease, cancer, chronic infections, and immune disorders may aid in disease diagnosis and prognosis and potentially identify new therapeutic targets.

show abstract

Section: Clinical Relevancementioning

confidence: 99%

Regulation of MicroRNA by Antagomirs

Mattes

Yang

Foster

2007

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

show abstract

“…miR-122 is expressed at high levels in the liver with more than 50,000 copies per cell, where it constitutes 70% of the total miRNA population (47;49;50). Although it was first thought that miRNA acted solely to down-regulate gene expression (51;52), recent results indicate that these small RNA's, in fact, produce both up-and down-regulation of different genes (53)(54)(55). Thus, their effects are multidimensional, and we still have much to learn about their global effects on cells.…”

mentioning

confidence: 99%

Reciprocal Effects of Micro-RNA-122 on Expression of Heme Oxygenase-1 and Hepatitis C Virus Genes in Human Hepatocytes

et al. 2007

View full text Add to dashboard Cite

show abstract

“…miR-122 antagomir can inhibit replication of HCV, abundance of HCV core RNA, and expression of HCV nonstructural proteins (NS3 in CNS3 cells and NS3-5B in 9-13 replicon cells), in a time-and dosedependent manner [51,[60][61][62][63]. These findings are suggestive of miR-122 as a potential target for antiviral interventions in HCV patients [37,57,[64][65][66][67].…”

Section: Roles Of Mirnas In Virus-induced Hccmentioning

confidence: 88%

The role and clinical implications of microRNAs in hepatocellular carcinoma

Zhao

Yang

et al. 2012

Sci. China Life Sci.

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis.

show abstract

A novel function for a micro RNA: Negative regulators can do positive for the hepatitis C virus

Cited by 10 publications

References 27 publications

Regulation of MicroRNA by Antagomirs

Regulation of MicroRNA by Antagomirs

Reciprocal Effects of Micro-RNA-122 on Expression of Heme Oxygenase-1 and Hepatitis C Virus Genes in Human Hepatocytes

The role and clinical implications of microRNAs in hepatocellular carcinoma

Contact Info

Product

Resources

About