A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep

Nakatsuka, Daiki; Kanda, Takeshi; Sato, Makito; Ishikawa, Yukiko; Cherasse, Yoan; Yanagisawa, Masashi

doi:10.1016/j.isci.2024.109289

iScience

2024

DOI: 10.1016/j.isci.2024.109289

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A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep

Daiki Nakatsuka,

Takeshi Kanda,

Makito Sato

et al.

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2024

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Cited by 2 publications

References 101 publications

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Commissural and monosynaptic inputs to medial vestibular nucleus GABAergic neurons in mice

Kong,

Liu

et al. 2024

Front. Neurol.

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ObjectiveMVN GABAergic neurons is involved in the rebalance of commissural system contributing to alleviating acute peripheral vestibular dysfunction syndrome. This study aims to depict monosynaptic inputs to MVN GABAergic neurons.MethodsThe modified rabies virus-based retrogradation method combined with the VGAT-IRES-Cre mice was used in this study. Moreover, the commissural connections with MVN GABAergic neurons were analyzed.ResultsWe identified 60 nuclei projecting to MVN GABAergic neurons primarily distributed in the cerebellum and the medulla. The uvula-nodulus, gigantocellular reticular nucleus, prepositus nucleus, intermediate reticular nucleus, and three other nuclei sent dense inputs to MVN GABAergic neurons. The medial (fastigial) cerebellar nucleus, dorsal paragigantocellular nucleus, lateral paragigantocellular nucleus and 10 other nuclei sent moderate inputs to MVN GABAergic neurons. Sparse inputs to MVN GABAergic neurons originated from the nucleus of the solitary tract, lateral reticular nucleus, pedunculopontine tegmental nucleus and 37 other nuclei. The MVN GABAergic neurons were regulated by the contralateral MVN, lateral vestibular nucleus, superior vestibular nucleus, and inferior vestibular nucleus.ConclusionOur study contributes to further understanding of the vestibular dysfunction in terms of neural circuits and search for new strategies to facilitate vestibular compensation.

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Commissural and monosynaptic inputs to medial vestibular nucleus GABAergic neurons in mice

Kong,

Liu

et al. 2024

Front. Neurol.

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Use of galvanic vestibular stimulation device as a countermeasure for microgravity effects in spaceflight

Soto,

Vega

2024

Front. Space Technol.

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This work discusses the challenges of space exploration, focusing on microgravity-induced physiological changes, particularly those affecting the vestibular system, which significantly alters human performance in space, necessitating effective countermeasures. In microgravity, astronauts experience disorientation and space motion sickness due to changes in vestibular input, leading to symptoms like vertigo and headache. Postflight, astronauts show various neurological changes, similar to symptoms in individuals with vestibular disorders experiencing significant cognitive and perceptual difficulties. Studies have also shown that microgravity affects cortical and sensory responses, altering perception, motor function, and brain connectivity. Galvanic Vestibular Stimulation (GVS) is explored as a countermeasure, using modulated electrical currents to evoke neuronal activity in vestibular end-organs, potentially stabilizing posture and gaze in microgravity. The work proposes that GVS could serve as a non-invasive intervention to help adapt to space environments by enhancing vestibular function and possibly aiding cognitive functions and underscores the need for continued research into the vestibular system’s role in human health and performance during space missions. It highlights the potential of GVS as a promising countermeasure for the challenges posed by microgravity.

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A novel GABAergic population in the medial vestibular nucleus maintains wakefulness and gates rapid eye movement sleep

Cited by 2 publications

References 101 publications

Commissural and monosynaptic inputs to medial vestibular nucleus GABAergic neurons in mice

Commissural and monosynaptic inputs to medial vestibular nucleus GABAergic neurons in mice

Use of galvanic vestibular stimulation device as a countermeasure for microgravity effects in spaceflight

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