A Novel Gammaherpesvirus Associated with Genital Lesions in a Blainville's Beaked Whale (Mesoplodon densirostris)

Saliki, Jeremiah T.; Cooper, Emily; Rotstein, David S.; Caseltine, Shannon L.; Pabst, D. Ann; McLellan, William A.; Govett, Pamela; Harms, Craig A.; Smolarek, Kara A.; Romero, Carlos H.

doi:10.7589/0090-3558-42.1.142

Cited by 46 publications

(27 citation statements)

References 11 publications

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“…From two γ-HV sequences belonging to the tentatively named Ziphiid herpesvirus 1 (ZiHV-1) [19] found in two M. densirostris stranded on the Atlantic coast of the USA (GenBank accession numbers AY803337 and AY949828) [8,9], where both sequences were 100% identical in a 47 aa region in this study.…”

Section: Discussionmentioning

confidence: 98%

Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris)

Arbelo

Bellière²,

Sierra

et al. 2012

BMC Vet Res

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BackgroundThe capacity for herpesvirus to cause disease in cetaceans is unclear and may be varied depending on the different conditions of individuals and between different species. Kidney pathology and intralesional virus-associated infection have been rarely reported in cetaceans.ResultOn April 2004, an old adult male Blainville’s beaked whale (Mesoplodon densirostris) 420 cm long with a poor body condition was stranded on Tenerife Island. During necropsy, no gross lesions were observed in the kidneys. However, membranous glomerulonephritis, multifocal interstitial lymphoplasmacytic nephritis and acute multifocal necrotizing tubulointerstitial nephritis with intranuclear inclusion bodies was diagnosed by histological analysis. Tissue samples were submitted for bacteriological analysis and molecular viral screening.ConclusionA novel alpha herpesvirus associated with interstitial nephritis was identified in an old adult male Blainville's beaked whale (M. densirostris) with a poor body condition stranded in the Canary Islands. This report suggests that identification of herpesvirus infection could be used as a differential diagnosis for interstitial nephritis in cetaceans.

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Section: Discussionmentioning

confidence: 98%

Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris)

Arbelo

Bellière²,

Sierra

et al. 2012

BMC Vet Res

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“…Hyperplasia with prominent papillae of the lamina propria and perinuclear vacuolation is more reminiscent of lesions caused by papillomavirus (Pamela et al, 2007). However herpesvirus has been associated with hyperplasia and papillomas in Neotropical parrots (Styles et al, 2004), cloacal papillomas in parrots (Johne et al, 2002), a papilloma-like penile lesion in a Blainville's beaked whale (Mesoplodon densirostris; Saliki et al, 2006), and fibropapillomatosis in marine turtles (Norton et al, 1990;Quackenbush et al, 1998). Although in parrots papillomavirus was initially suspected to be causative for the papillomas, it could not be detected in two investigations into the etiology (Johne et al, 2002;Styles et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Genital lesions associated with herpesvirus infection have been found in three cetacean species. A penis lesion in a Blainville's beaked whale (Mesoplodon densirostris) had basophilic intranuclear inclusion bodies and contained herpesviral DNA by PCR that was classified as belonging to a gammaherpesvirus (Saliki et al, 2006). Genital lesions from five bottlenose dolphins and one Risso's dolphin (Grampus griseus) contained herpesvirus DNA by PCR that were classified as belonging to gammaherpesviruses (Smolarek Benson et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Genital Herpesvirus in Bottlenose Dolphins (Tursiops Truncatus): Cultivation, Epidemiology, and Associated Pathology

Elk

Bildt

Jong

et al. 2009

Journal of Wildlife Diseases

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ABSTRACT:We studied the pathology, epidemiology, and clinical significance of genital herpesvirus infection in a zoo collection of bottlenose dolphins (Tursiops truncatus). Samples from the genital mucosa of male (n521) and female (n515) dolphins were tested by nested polymerase chain reaction (PCR) targeting the DNA polymerase of herpesvirus. Herpesvirus infection was significantly associated with the occurrence of mucosal plaques on penis (n53) or vulva (n54). Biopsies from a penile plaque showed epithelial hyperplasia by histology, contained herpesvirus-like particles by electron microscopy, and tested positive for herpesvirus by PCR. Herpesvirus was successfully cultivated from penile plaque samples and identified as a member of the Gammaherpesvirinae by DNA sequencing and phylogenetic analysis. We used the newly cultivated bottlenose dolphin herpesvirus (TTHV) to develop a direct enzyme-linked immunosorbent assay for anti-TTHV antibodies in banked sera of these dolphins. The percentage of positive samples was higher in adults (20/21, 95%) than in juveniles (7/15, 47%). Seroconversion occurred around the age of onset of sexual behavior. Although herpesvirus infection has been associated with abortion, perinatal mortality, and urogenital neoplasia in other species, we found no evidence of herpesvirus infection by PCR in tissues from six cases of abortion and perinatal mortality, and no diagnoses of urogenital tumors in 24 bottlenose dolphins from this zoo collection that died since 1990. Together, we here report the first successful cultivation from bottlenose dolphins of a herpesvirus that probably causes benign genital plaques, is endemic in this group of dolphins, and is likely transmitted by sexual contact.

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“…Skin lesions have been attributed to a herpesvirus etiology in cetacean species by three diagnostic criteria: 1) their gross or histologic appearance (Greenwood et al 1974;Baker 1992;Baker and Martin 1992), 2) ultrastructural demonstration of herpeslike viral particles (Martineau et al 1988;Barr et al 1989;Van Bressem et al 1994), and 3) molecular criteria (Smolarek Benson et al 2006;Sierra et al 2014). Genital herpesvirus lesions have been described associated with plaquelike or proliferative wounds in bottlenose and Risso's dolphins (Tursiops truncatus and Grampus griseus; Smolarek Benson et al 2006), two Blainville's beaked whales (Mesoplodon densirostris; Saliki et al 2006;Smolarek Benson et al 2006), and a beluga whale (Delphinapterus leucas; Bellehumeur et al 2015). Except for the harbor porpoise (Phocoena phocoena), molecular diagnosis was performed on all those cases, and the corresponding sequences are available in GenBank.…”

Section: Introductionmentioning

confidence: 99%

HERPESVIRUS-ASSOCIATED GENITAL LESIONS IN A STRANDED STRIPED DOLPHIN (STENELLA COERULEOALBA) IN THE CANARY ISLANDS, SPAIN

Sierra

Díaz‐Delgado

Arbelo

et al. 2015

Journal of Wildlife Diseases

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ABSTRACT:An adult male striped dolphin (Stenella coeruleoalba) stranded alive at Arico, Tenerife, Canary Islands, Spain. The dolphin died shortly after stranding, and a complete postmortem examination was performed. The most remarkable gross findings were two fleshy masses of approximately 1 cm diameter, near the tip of the penis. These masses were composed of hyperplastic epithelial cells with pigmentary incontinence. Ballooning degeneration and margination of chromatin was observed within the stratum corneum of the epidermis. A universal nested PCR assay that amplifies a conserved region within the polymerase gene of Herpesviridae was positive. The sequenced product was most closely related to a gammaherpesvirus that shared nucleotide identities of 93% with penile lesions from Atlantic and Mediterranean bottlenose dolphins (Tursiops truncatus). This similarity supports the hypothesis of sexual transmission between species.

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A Novel Gammaherpesvirus Associated with Genital Lesions in a Blainville's Beaked Whale (Mesoplodon densirostris)

Cited by 46 publications

References 11 publications

Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris)

Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris)

Genital Herpesvirus in Bottlenose Dolphins (Tursiops Truncatus): Cultivation, Epidemiology, and Associated Pathology

HERPESVIRUS-ASSOCIATED GENITAL LESIONS IN A STRANDED STRIPED DOLPHIN (STENELLA COERULEOALBA) IN THE CANARY ISLANDS, SPAIN

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