A novel gas embolotherapy using microbubbles electrocoalescence for cancer treatment

Sormoli, Hossein Azizi; Mojra, Afsaneh; Heidarinejad, Ghassem

doi:10.1016/j.cmpb.2023.107953

Cited by 5 publications

(1 citation statement)

References 56 publications

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“…These improvements offer prospects for implementing bubble valve strategies. 55–57 Secondly, in the measurement of the apparent viscosity of leukocytes, we did not rigorously differentiate between the activation states of the cells. Distinguishing the states of leukocytes within a living organism is inherently challenging.…”

Section: Discussionmentioning

confidence: 99%

Laser-induced microbubble as an in vivo valve for optofluidic manipulation in living Mice's microvessels

Shao,

Li,

Meng

et al. 2024

Lab Chip

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Section: Discussionmentioning

confidence: 99%

Laser-induced microbubble as an in vivo valve for optofluidic manipulation in living Mice's microvessels

Shao,

Li,

Meng

et al. 2024

Lab Chip

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Analysis of HIFU thermal ablation for lung cancer incorporating local thermal non-equilibrium and non-Fourier transfer

Zeinali,

Mojra,

Vafai

2024

International Communications in Heat and Mass Transfer

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Numerical analysis of ultrasound-mediated microbubble interactions in vascular systems: Effects on shear stress and vessel mechanics

Heidary,

Ohl,

Mojra

2024

Physics of Fluids

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The present study concerns the numerical modeling of microbubble oscillation within an elastic microvessel, aiming to enhance the safety and efficacy of ultrasound-mediated drug delivery and diagnostic imaging. The success of such applications depends on a thorough understanding of microbubble–vessel interactions. Despite some progress, the critical impact of the stabilizing shell around gas core has remained underexplored. To address this, we developed a novel numerical approach that models the stabilizing shell. Additionally, there is novelty in modeling consequent vascular deformation in response to complicated spatiotemporal microbubble oscillations. The novel approach was implemented for shear stress evaluation as a critical factor in vascular permeability. Finally, our unique approach offered novel insights into microbubble–vessel interactions under diverse acoustic conditions. Results indicated substantial impact of shell properties and acoustic parameters on induced shear stress. With a fourfold increase in acoustic pressure amplitude, 15.6-fold and sixfold increases were observed in maximum shear stress at 1 and 3 MHz, respectively. Also, the peak shear stress could reach up to 15.6 kPa for a shell elasticity of 0.2 N/m at 2.5 MHz. Furthermore, decreasing microvessel/bubble size ratio from 3 to 1.5 increased maximum shear stress from 5.1 to 24.3 kPa. These findings are crucial for optimizing ultrasound parameters in clinical applications, potentially improving treatment outcomes while minimizing risk of vessel damage. However, while our model demonstrated high fidelity in reproducing experimental observations, it is limited by assumptions of vessel geometry and homogeneity of vessel properties. Future work can improve our findings through in vitro experimental measurements.

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A novel gas embolotherapy using microbubbles electrocoalescence for cancer treatment

Cited by 5 publications

References 56 publications

Laser-induced microbubble as an in vivo valve for optofluidic manipulation in living Mice's microvessels

Laser-induced microbubble as an in vivo valve for optofluidic manipulation in living Mice's microvessels

Analysis of HIFU thermal ablation for lung cancer incorporating local thermal non-equilibrium and non-Fourier transfer

Numerical analysis of ultrasound-mediated microbubble interactions in vascular systems: Effects on shear stress and vessel mechanics

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