A Novel Gas Phase Method for the Combined Synthesis and Coating of Pharmaceutical Particles

Raula, Janne; Lähde, Anna; Kauppinen, Esko I.

doi:10.1007/s11095-007-9464-4

Cited by 33 publications

(24 citation statements)

References 12 publications

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“…They did not report the film thickness on particles due to an inability to perform thickness estimation, resulting from the non-uniform nature of the particle surfaces (Singh et al, 2002). A modified spray drying method, which can be used both for drug particle synthesis and particle coating by physical vapour deposition, has been developed and studied for synthesizing drug particles (Eerikäinen et al, 2003), for coating salbutamol sulfate particles with L-leucine (Raula et al, 2008), for encapsulating indomethacin nanocrystals in mannitol microparticles with an L-leucine coating , and for combining budesonide and salbutamol in microparticles coated with L-leucine (Raula et al, 2013;Vartiainen et al, 2016). In this method, APIs, binders and coating material are dissolved in water to form a precursor solution which is used in an aerosol process.…”

Section: Introductionmentioning

confidence: 99%

Surface modification of acetaminophen particles by atomic layer deposition

Kääriäinen

Kemell

Vehkamäki

et al. 2017

International Journal of Pharmaceutics

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Active pharmaceutical ingredients (APIs) are predominantly organic solid powders. Due to their bulk properties many APIs require processing to improve pharmaceutical formulation and manufacturing in the preparation for various drug dosage forms. Improved powder flow and protection of the APIs are often anticipated characteristics in pharmaceutical manufacturing. In this work, we have modified acetaminophen particles with atomic layer deposition (ALD) by conformal nanometer scale coatings in a one-step coating process. According to the results, ALD, utilizing common chemistries for Al2O3, TiO2 and ZnO, is shown to be a promising coating method for solid pharmaceutical powders. Acetaminophen does not undergo degradation during the ALD coating process and maintains its stable polymorphic structure. Acetaminophen with nanometer scale ALD coatings shows slowed drug release. ALD TiO2 coated acetaminophen particles show cytocompatibility whereas those coated with thicker ZnO coatings exhibit the most cytotoxicity among the ALD materials under study when assessed in vitro by their effect on intestinal Caco-2 cells.

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Section: Introductionmentioning

confidence: 99%

Surface modification of acetaminophen particles by atomic layer deposition

Kääriäinen

Kemell

Vehkamäki

et al. 2017

International Journal of Pharmaceutics

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“…The structure of the coating could be controlled by the degree of saturation of the L-leucine. All the powders where salbutamol sulphate cores were coated via L-leucine vapour exhibited excellent flow and gas-phase dispersion characteristics (24).…”

Section: Introductionmentioning

confidence: 99%

Investigations on the Humidity-Induced Transformations of Salbutamol Sulphate Particles Coated with l-Leucine

Raula¹,

Thielmann

Kansikas

et al. 2008

Pharm Res

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“…We recently reported the preparation of salbutamol sulphate particles coated with amino acid L-leucine in an aerosol flow reactor (12)(13)(14)(15). At fixed saturation conditions, L-leucine formed a crystalline encapsulating layer by molecular diffusion to the droplet surface or a crystalline, rough nano-sized coating layer by physical vapour deposition (PVD) or both of the layers at particle surface.…”

Section: Introductionmentioning

confidence: 99%

Structure and Dissolution of l-Leucine-Coated Salbutamol Sulphate Aerosol Particles

et al. 2012

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Abstract. L-Leucine formed different crystalline coatings on salbutamol sulphate aerosol particles depending on the saturation conditions of L-leucine. The work emphasizes a careful characterization of powders where structural compartments such as crystal size and particle coating may affect the performance of drug when administered. The sublimation of L-leucine from the aerosol particles took place 90°C lower temperature than the bulk L-leucine which was attributed to result from the sublimation of L-leucine from nano-sized crystalline domains. The dissolution slowed down and initial dissolution rate decreased with increasing L-leucine content. Decreasing crystalline domains to nano-scale improve heat and mass transfer which was observed as the lowered decomposition temperature of the drug salbutamol sulphate and the sublimation temperature of surface material L-leucine as well as the altered dissolution characteristics of the drug. The structure of the coated drug particles was studied by means of thermal analysis techniques (DSC and TG), and the dissolution of salbutamol sulphate was studied as an on-line measurement in a diffusion cell.

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A Novel Gas Phase Method for the Combined Synthesis and Coating of Pharmaceutical Particles

Cited by 33 publications

References 12 publications

Surface modification of acetaminophen particles by atomic layer deposition

Surface modification of acetaminophen particles by atomic layer deposition

Investigations on the Humidity-Induced Transformations of Salbutamol Sulphate Particles Coated with l-Leucine

Structure and Dissolution of l-Leucine-Coated Salbutamol Sulphate Aerosol Particles

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