A novel gastric release PEG‐enclatherated polymethacrylate‐based memblet system

Abstract

A novel polymethacrylate‐based membranous system referred to as a “memblet” was developed for potential application in controlled gastric drug delivery. A polymethacrylate‐based latex, Eudragit® E100, was enclatherated with a 60% w/v and a 30% w/v solution of polyethylene glycol 4000 to form hydrogel formulations A and B, respectively. The hydrogels were subsequently compressed into memblets that were characterized for thermal, rheological, morphological, mechano‐chemical properties, and in vitro gastric drug release analysis. Molecular mechanics (MM) simulations were performed to corroborate the experimental findings. Critical yield values of 15.39 and 5.239 Pa were obtained for hydrogel A and B, respectively. The viscoelastic region was found to be <10.67 and 2.542 Pa for hydrogels A and B, respectively. The storage modulus was greater than the loss modulus for hydrogel A while the inverse was true for hydrogel B. Thermal, mechanical, and surface morphology evaluation revealed that the converse was true for the dried membrane structure with hydrogel B having superior characterization profiles than hydrogel A. Notably, the lower PEG concentration (30% w/v) displayed better characterization profiles than a higher concentration (60% w/v). Through MM simulations, desirable agreement between the theoretical and experimental results was achieved over the given concentration range of PEG. Based on the gastric drug release analysis, memblets formulated with hydrogel B displayed superior control of drug release. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

In silico analytico‐mathematical interpretation of biopolymeric assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations

“…These charged regions may further distort the electrostatic balance of the polymeric matrix causing repulsion and a strained network. However at 30% wt/vol PEG4000 concentration, the PEG‐enclatherated polymethacrylate system was comparatively more geometrically stabilized with defined viscoelastic regions and consistent drug release profile . In a unique “co‐blending‐co‐plasticizing” strategy, Jones and coworkers used HPMC and Eudragit RS100 to make a bipolymeric buccal film and added two plasticizers, namely, glycerin (GLY) and triethyl citrate (TEC) to plasticize the individual polymers, respectively.…”

“…17 concentration, the PEG-enclatherated polymethacrylate system was comparatively more geometrically stabilized with defined viscoelastic regions and consistent drug release profile. 22 In a unique "co-blending-co-plasticizing" strategy, Jones and coworkers used HPMC and Eudragit RS100 to make a bipolymeric buccal film and added two plasticizers, namely, glycerin (GLY) and triethyl citrate (TEC) to plasticize the individual polymers, respectively. This complex system demonstrated varied drug release profiles dependent on the concentration of the components.…”

Microwave‐Promoted Synthesis of Smart Superporous Hydrogel for the Development of Gastroretentive Drug Delivery System

“…Several approaches are being designed and developed for increasing the residence time of dosage form in the stomach such as high density (sinking) systems that is retained in the bottom of the stomach, low-density (floating) systems that causes buoyancy in gastric fluid, mucoadhesive systems, unfoldable, extendible, or swellable superporous hydrogel (SPH) systems, magnetic systems etc. [7][8][9][10] SPHs are three-dimensional networks of hydrophilic polymers that contain many pores that are hundreds of micrometers in diameter. 11 Because these hydrogels absorb a large volume of surrounding environmental fluids, which expand their volume considerably over a very short time, their sheer bulk hinders their transport to the next organ via the narrow pylorus.…”

“…The current controlled release technology has made it possible to release drugs at a constant rate for longer periods of time ranging from hours to even days. Several approaches are being designed and developed for increasing the residence time of dosage form in the stomach such as high density (sinking) systems that is retained in the bottom of the stomach, low‐density (floating) systems that causes buoyancy in gastric fluid, mucoadhesive systems, unfoldable, extendible, or swellable superporous hydrogel (SPH) systems, magnetic systems etc …”