A novel Gd<sup>3+</sup> DTPA-bisamide complex with high relaxivity as an MRI contrast agent

Ru, Jiaxi; Xu, Wenli; Kou, Manchang; Dong, Hui; Tang, Xiaoliang; Kang, Lingling; Dai, Lixiong; Liang, Changhong

doi:10.1039/d3tb00720k

J. Mater. Chem. B

2023

DOI: 10.1039/d3tb00720k

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A novel Gd³⁺ DTPA-bisamide complex with high relaxivity as an MRI contrast agent

Jiaxi Ru

Wenli Xu

Manchang Kou

et al.

Abstract: A novel Gd(iii) complex-based MRI contrast agent GdL has been designed and synthesized, which exhibited a much higher relaxivity than the commercially used Magnevist®, good water solubility, excellent stability, high biosafety and biocompatibility.

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2024

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Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Yang,

Hu,

Yang

et al. 2024

Adv Funct Materials

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The lanthanide complex, characterized by narrow emission bands, large Stokes shifts, long luminescence lifetime, robust resistance to photobleaching, and magnetic properties, affords significant promise for molecular imaging and biosensing applications. While most lanthanide complexes emitting visible light are extensively studied for cellular‐level detection and bioimaging, near‐infrared‐emitted (700–1700 nm) lanthanide compounds exhibit more favorable properties for bioimaging and biosensing, ascribed from deeper penetration and reduced bleaching effects. Besides, the magnetic lanthanide complex with higher magnetic resonance signals can enhance image resolution and sensitivity, offering more precise bioimaging analysis. However, the widespread use of high‐efficiency luminescence lanthanide complexes is currently impeded by the lack of design approaches for improving magnetic properties and sensitization chromophores with extended excitation and emission wavelengths. In this review, some fundamental theories and design strategies of lanthanide complexes are summarized for luminescence imaging, lifetime‐engineered imaging, magnetic resonance imaging, and dual‐modal imaging, and now highlight a selection of bioimaging and biosensing applications. The review addresses the existing gap in the literature by proposing some feasible approaches for improving the fluorescent and magnetic properties. Concurrently, future challenges and opportunities in the field of lanthanide complex probes are discussed.

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Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Yang,

Hu,

Yang

et al. 2024

Adv Funct Materials

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Structural regulation strategy for Dy-MOFs based on [Qn+][Dy(β-diketonate)4-]n (Qn+ = Et3NH+, Et4N+, R-H2MPPA2+)

Chen,

Jiang,

Zhu

et al. 2024

Journal of Molecular Structure

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Solvent-Induced Magnetic Properties of a Series of Dy-Based MOFs from Two Different Precursor Complexes

Jiang,

Huang,

et al. 2024

Crystal Growth & Design

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It is still challenging for Dy-MOFs to modulate the single-molecule magnet (SMM) behavior through guest molecules. Dy-MOFs with different guest molecules, secondary building units, and linkers were synthesized by precursors and bridging carboxylic acid ligands, and the magnetic properties of Dy-MOFs were regulated by guest molecules. These differentiated Dy-MOFs are [Dy 2). The single-crystal X-ray diffraction showed that MOF-3 and MOF-5 are two-dimensional MOFs with square holes. MOF-4 is a two-dimensional MOF formed by hydrogen−halogen bonds, and MOF-6, MOF-7, and MOF-8 are one-dimensional chains. The magnetic test results show that MOF-4, MOF-6, and MOF-8 show SMM behavior under zero field, and MOF-3 and MOF-5 exhibit field-induced SMM behavior. In the zero field, the effective energy bases of MOF-4, MOF-6, and MOF-8 are 37.09, 19.56, and 15.73 K, and relaxation times τ 0 were 4.66 × 10 −6 , 2.35 × 10 −6 , and 9.95 × 10 −6 s, respectively. This work provides a vivid example of regulating the molecular magnetism of Dy-MOFs and promotes the progress of Dy-MOF crystal engineering.

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A novel Gd³⁺ DTPA-bisamide complex with high relaxivity as an MRI contrast agent

Abstract: A novel Gd(iii) complex-based MRI contrast agent GdL has been designed and synthesized, which exhibited a much higher relaxivity than the commercially used Magnevist®, good water solubility, excellent stability, high biosafety and biocompatibility.

Cited by 4 publications

References 34 publications

Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Structural regulation strategy for Dy-MOFs based on [Qn+][Dy(β-diketonate)4-]n (Qn+ = Et3NH+, Et4N+, R-H2MPPA2+)

Solvent-Induced Magnetic Properties of a Series of Dy-Based MOFs from Two Different Precursor Complexes

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A novel Gd3+ DTPA-bisamide complex with high relaxivity as an MRI contrast agent

Abstract: A novel Gd(iii) complex-based MRI contrast agent GdL has been designed and synthesized, which exhibited a much higher relaxivity than the commercially used Magnevist®, good water solubility, excellent stability, high biosafety and biocompatibility.

Cited by 4 publications

References 34 publications

Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Structural regulation strategy for Dy-MOFs based on [Qn+][Dy(β-diketonate)4-]n (Qn+ = Et3NH+, Et4N+, R-H2MPPA2+)

Solvent-Induced Magnetic Properties of a Series of Dy-Based MOFs from Two Different Precursor Complexes

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Product

Resources

About

A novel Gd³⁺ DTPA-bisamide complex with high relaxivity as an MRI contrast agent