A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An  ex-Vivo Study

Alhalawani, Adel M.F.; Curran, Declan J.; Pingguan‐Murphy, Belinda; Boyd, Daniel

doi:10.3390/jfb4040329

Cited by 19 publications

(22 citation statements)

References 66 publications

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“…7). The increased with incubation time, as expected from the literature [40]. The scaffold containing 10 % bioglass had the highest ion release rate and POC-BG-30 % had the lowest for the four ions.…”

Section: Ion Release Experimentssupporting

confidence: 73%

“…There were small differences between the wettability of all the compositions and the results were in the range of 58°-62°. Alhalawani et al reported that the addition of Ga to a bioglass led to increased hydrophilicity which in turn can be a reason for enhancement of wettability of our composites [40]. The composite films indicated lower contact angle compared with the pure polymer, presumably due to hydrophilic nature of bioglass.…”

Section: Water In Air Contact Anglementioning

confidence: 99%

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Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

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Section: Ion Release Experimentssupporting

confidence: 73%

Section: Water In Air Contact Anglementioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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“…The reaction between both components results in a composite cement material consisting of reacted and unreacted glass particles embedded in a polysalt matrix [2][3][4]. GPCs are used in dentistry due to a selection of clinical advantages as follows [2,[5][6][7][8][9]: (a) Single-step adhesion characteristics of both enamel and dentine. These features have made them attractive candidates for expanded applications in hard tissue repair.…”

Section: Introductionmentioning

confidence: 99%

The role of poly(acrylic acid) in conventional glass polyalkenoate cements

Alhalawani

Curran

Boyd

et al. 2015

Journal of Polymer Engineering

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Abstract Glass polyalkenoate cements (GPCs) have been used in dentistry for over 40 years. These novel bioactive materials are the result of a reaction between a finely ground glass (base) and a polymer (acid), usually poly(acrylic acid) (PAA), in the presence of water. This article reviews the types of PAA used as reagents (including how they vary by molar mass, molecular weight, concentration, polydispersity and content) and the way that they control the properties of the conventional GPCs (CGPCs) formulated from them. The article also considers the effect of PAA on the clinical performance of CGPCs, including biocompatibility, rheological and mechanical properties, adhesion, ion release, acid erosion and clinical durability. The review has critically evaluated the literature and clarified the role that the polyacid component of CGPCs plays in setting and maturation. This review will lead to an improved understanding of the chemistry and properties of the PAA phase which will lead to further innovation in the glass-based cements field.

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“…They bond chemically to hydroxyapatite (HA) and release beneficial ions that can help prevent caries, such as fluorine or silver [ 14 , 15 ]. The advantages of using GPC in dentistry include the GPC’s biocompatibility, bioactivity, high-dimensional stability, good resistance to cohesive failure, negligible shrinkage upon setting, among other advantages [ 16 , 17 , 18 , 19 ]. Numerous applications of GPCs have been investigated to expand its current use to other applications.…”

Section: Introductionmentioning

confidence: 99%

Incorporating Germanium Oxide into the Glass Phase of Novel Zinc/Magnesium-Based GPCs Designed for Bone Void Filling: Evaluating Their Physical and Mechanical Properties

Khader

Rodriguez

Towler

2018

JFB

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The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO2–0.12CaO–0.36ZnO–0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass polyalkenoate cements (GPCs) manufactured from them. The Network connectivity (NC) of the glass was calculated to increase from 1.83 to 2.42 with the addition of GeO2 (0–8 mol %). Differential thermal analysis (DTA) results confirmed an increase in the glass transition temperature (Tg) of the glass series with GeO2 content. X-ray photoelectron spectroscopy (XPS) showed an increase in the ratio of bridging oxygens (BO) to non-bridging oxygens (NBO) with the addition of GeO2, supporting the NC and DTA results. 29Si magic angle spinning nuclear magnetic resonance spectroscopy (29Si MAS-NMR) determined a chemical shift from −80.3 to −83.7 ppm as the GeO2 concentration increased. These ionomeric glasses were subsequently used as the basic components in a series of GPCs by mixing them with aqueous polyacrylic acid (PAA). The handling properties of the GPCs resulting were evaluated with respect to the increasing concentration of GeO2 in the glass phase. It was found that the working times of these GPCs increased from 3 to 15 min, while their setting times increased from 4 to 18 min, facilitating the injectability of the Zn/Mg-GPCs through a 16-gauge needle. These Ge-Zn/Mg-GPCs were found to be injectable up to 96% within 12 min. Zn/Mg-GPCs containing GeO2 show promise as injectable cements for use in bone void filling.

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A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An ex-Vivo Study

Cited by 19 publications

References 66 publications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

The role of poly(acrylic acid) in conventional glass polyalkenoate cements

Incorporating Germanium Oxide into the Glass Phase of Novel Zinc/Magnesium-Based GPCs Designed for Bone Void Filling: Evaluating Their Physical and Mechanical Properties

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