A novel glucose biosensor based on the nanoscaled cobalt phthalocyanine–glucose oxidase biocomposite

Wang, Kun; Xu, Jing‐Juan; Chen, Hong‐Yuan

doi:10.1016/j.bios.2004.06.006

Cited by 128 publications

(35 citation statements)

References 58 publications

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“…Cobalt-based nanoparticles may be produced as cobalt oxide, organic metal compounds or biopolymers (28). In biomedical applications, cobalt-based nanoparticles are used as starting materials for the formation of magnetic polymer microspheres and dextran coating.…”

Section: Genotoxicity and Carcinogenicity Of Cobalt-based Nano-particlesmentioning

confidence: 99%

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

Magaye

Zhao

Bowman

et al. 2012

Experimental and Therapeutic Medicine

193

118

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The nanotechnology industry has matured and expanded at a rapid pace in the last decade, leading to the research and development of nanomaterials with enormous potential. The largest source of these nanomaterials is the transitional metals. It has been revealed that numerous properties of these nano-sized elements are not present in their bulk states. The nano size of these particles means they are easily transported into biological systems, thus, raising the question of their effects on the susceptible systems. Although advances have been made and insights have been gained on the effect of transitional metals on susceptible biological systems, there still is much ground to be covered, particularly with respect to our knowledge on the genotoxic and carcinogenic effects. Therefore, this review intends to summarize the current knowledge on the genotoxic and carcinogenic potential of cobalt-, nickel- and copper-based nanoparticles indicated in in vitro and in vivo mammalian studies. In the present review, we briefly state the sources, use and exposure routes of these nanoparticles and summarize the current literature findings on their in vivo and in vitro genotoxic and carcinogenic effects. Due to the increasing evidence of their role in carcinogenicity, we have also included studies that have reported epigenetic factors, such as abnormal apoptosis, enhanced oxidative stress and pro-inflammatory effects involving these nanoparticles.

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Section: Genotoxicity and Carcinogenicity Of Cobalt-based Nano-particlesmentioning

confidence: 99%

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

Magaye

Zhao

Bowman

et al. 2012

Experimental and Therapeutic Medicine

193

118

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“…Metallic cobalt, as nanoparticles, is used in biology and medicine in different forms from the simplest, such as cobalt oxide, to complex, such as organic compounds or biopolymers. 10–11 …”

Section: Introductionmentioning

confidence: 99%

DNA Damage Caused by Metal Nanoparticles: Involvement of Oxidative Stress and Activation of ATM

Wan

Feng

et al. 2012

Chem. Res. Toxicol.

164

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Nanotechnology is a fast growing emerging field, the benefits of which are widely publicized. Our current knowledge of the health effects of metal nanoparticles such as nano-sized cobalt (Nano-Co) and titanium dioxide (Nano-TiO2) is limited but suggests that metal nanoparticles may exert more adverse pulmonary effects as compared with standard-sized particles. To investigate metal nanoparticle-induced genotoxic effects and the potential underlying mechanisms, human lung epithelial cell lines A549 cells were exposed to Nano-Co and Nano-TiO2. Our results showed that exposure of A549 cells to Nano-Co caused reactive oxygen species (ROS) generation that was abolished by pretreatment of cells with ROS inhibitors or scavengers, such as catalase and N-acetyl-L(+)-cysteine (NAC). However, exposure of A549 cells to Nano-TiO2 did not cause ROS generation. Nano-Co caused DNA damage in A549 cells which was reflected by an increase in length, width, and DNA content of the comet tail by Comet assay. Exposure of A549 cells to Nano-Co also caused a dose-and a time- response increased expression of phosphorylated histone H2AX (γ-H2AX), Rad51 and phosphorylated p53. These effects were significantly attenuated when A549 cells were pre-treated with catalase or NAC. Nano-TiO2 did not show these effects. These results suggest that oxidative stress may be involved in Nano-Co-induced DNA damage. To further investigate the pathways involved in the Nano-Co-induced DNA damage, we measured the phosphorylation of ataxia telangiectasia mutant (ATM). Our results showed that phosphorylation of ATM was increased when A549 cells were exposed to Nano-Co, and this effect was attenuated when cells were pretreated with catalase or NAC. Pre-treatment of A549 cells with an ATM specific inhibitor, KU55933, significantly abolished Nano-Co-induced DNA damage. Furthermore, pre-treatment of A549 cells with ROS scavengers, such as catalase and NAC, significantly abolished Nano-Co-induced increased expression of phosphorylated ATM. Taken together, oxidative stress and ATM activation are involved in Nano-Co-induced DNA damage. These findings have important implications for understanding the potential health effects of metal nanoparticle exposure.

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“…In the GO categories, using predicted target genes, some genes are involved in the categories “response to metal ion,” “response to inorganic substance,” “positive regulation of nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process,” “response to xenobiotic stimulus,” “positive regulation of biosynthetic process,” in the W‐PM 2.5 group. Metal ions can regulate the generation of reactive oxygen species (ROS) that causes DNA damage (Ahamed et al, ; Jeon et al, ; Wang et al, ) and activation of TNF‐α and p38 MAPK signals in human body (Chattopadhyay et al, ; Shim et al, ). Many of the predicted target genes of O‐PM 2.5 are involved in cell cycle processes regulated by many genes, in categories such as “DNA metabolic process,” “DNA replication,” “regulation of cell cycle,” “cell cycle process,” “M phase,” etc.…”

Section: Discussionmentioning

confidence: 99%

Integrative analysis of mRNA and microRNA expression of a human alveolar epithelial cell(A549) exposed to water and organic‐soluble extract from particulate matter (PM)_2.5

Jeong

Song

Cho

et al. 2016

Environmental Toxicology

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MicroRNA (miRNA) is now attracting attention as a powerful negative regulator of messenger RNA(mRNA) levels, and is implicated in the modulation of important mRNA networks involved in toxicity. In this study, we assessed the effects of particulate matter 2.5 (PM ), one of the most significant air pollutants, on miRNA and target gene expression. We exposed human alveolar epithelial cell (A549) to two types of PM [water (W-PM ) and organic (O-PM ) soluble extracts] and performed miRNA microarray analysis. A total of 37 miRNAs and 62 miRNAs were altered 1.3-fold in W-PM and O-PM , respectively. Integrated analyses of miRNA and mRNA expression profiles identified negative correlations between miRNA and mRNA in both W-PM and O-PM exposure groups. Gene ontology and Kyoto encyclopedia of genes and genomes (KEGG) pathway analyses showed that the 35 W-PM target genes are involved in responses to nutrients, positive regulation of biosynthetic processes, positive regulation of nucleobase, nucleoside, and nucleotide, and nucleic acid metabolic processes; while the 69 O-PM target genes are involved in DNA replication, cell cycle processes, the M phase, and the cell cycle check point. We suggest that these target genes may play important roles in PM -induced respiratory toxicity by miRNA regulation. These results demonstrate an integrated miRNA-mRNA approach for identifying molecular events induced by environmental pollutants in an in vitro human model. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 302-310, 2017.

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A novel glucose biosensor based on the nanoscaled cobalt phthalocyanine–glucose oxidase biocomposite

Cited by 128 publications

References 58 publications

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

DNA Damage Caused by Metal Nanoparticles: Involvement of Oxidative Stress and Activation of ATM

Integrative analysis of mRNA and microRNA expression of a human alveolar epithelial cell(A549) exposed to water and organic‐soluble extract from particulate matter (PM)_2.5

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A novel glucose biosensor based on the nanoscaled cobalt phthalocyanine–glucose oxidase biocomposite

Cited by 128 publications

References 58 publications

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

Genotoxicity and carcinogenicity of cobalt-, nickel- and copper-based nanoparticles

DNA Damage Caused by Metal Nanoparticles: Involvement of Oxidative Stress and Activation of ATM

Integrative analysis of mRNA and microRNA expression of a human alveolar epithelial cell(A549) exposed to water and organic‐soluble extract from particulate matter (PM)2.5

Contact Info

Product

Resources

About

Integrative analysis of mRNA and microRNA expression of a human alveolar epithelial cell(A549) exposed to water and organic‐soluble extract from particulate matter (PM)_2.5