A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: Purification, structure identification and anticoagulant activity

Li, Guoyun; Chen, Shiguo; Wang, Yuming; Xue, Yong; Chang, Yaoguang; Li, Zhaojie; Wang, Jingfeng; Xue, Changhu

doi:10.1016/j.ijbiomac.2011.09.017

Cited by 59 publications

(23 citation statements)

References 21 publications

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“…Uniquely sulphated polysaccharides are found in marine sources and have a complex structure composed of galactose, fucose, glucuronic acid, galactosamine in quotient of 1:2.94:2.37 and 2.14 respectively. The quantitative ratio of sulphate was about 5.5% with an average molecular weight (MW) of 56.2 kDa (Li et al, 2011). The chemical structure of AAP, a carbohydrate isolated by Li et al (2011) contains galactosamine and glucuronic acid backbone linked to sulphated-fucose, and galactose, considered to be similar to the fucosylated chondroitin sulphate present in the sea cucumber .…”

Section: Anti-thrombotic and Anti-coagulant Perspectivesmentioning

confidence: 99%

“…The quantitative ratio of sulphate was about 5.5% with an average molecular weight (MW) of 56.2 kDa (Li et al, 2011). The chemical structure of AAP, a carbohydrate isolated by Li et al (2011) contains galactosamine and glucuronic acid backbone linked to sulphated-fucose, and galactose, considered to be similar to the fucosylated chondroitin sulphate present in the sea cucumber . In abalone even though AAP is linked with galactose to fucose branch, it is still considered a chondroitin-like polysaccharide (Li et al, 2011).…”

Section: Anti-thrombotic and Anti-coagulant Perspectivesmentioning

confidence: 99%

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Therapeutic potential of abalone and status of bioactive molecules: A comprehensive review

Suleria

Masci

Gobé

et al. 2015

Critical Reviews in Food Science and Nutrition

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Marine organisms are increasingly being investigated as sources of bioactive molecules with therapeutic applications as nutraceuticals and pharmaceuticals. In particular, nutraceuticals are gaining popularity worldwide owing to their therapeutic potential and incorporation in functional foods and dietary supplements. Abalone, a marine gastropod, contains a variety of bioactive compounds with anti-oxidant, anti-thrombotic, anti-inflammatory, anti-microbial, and anti-cancer activities. For thousands of years different cultures have used abalone as a traditional functional food believing consumption provides health benefits. Abalone meat is one of the most precious commodities in Asian markets where it is considered a culinary delicacy. Recent research has revealed that abalone is composed of many vital moieties like polysaccharides, proteins, and fatty acids that provide health benefits beyond basic nutrition. A review of past and present research is presented with relevance to the therapeutic potential of bioactive molecules from abalone.

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Section: Anti-thrombotic and Anti-coagulant Perspectivesmentioning

confidence: 99%

Section: Anti-thrombotic and Anti-coagulant Perspectivesmentioning

confidence: 99%

Therapeutic potential of abalone and status of bioactive molecules: A comprehensive review

Suleria

Masci

Gobé

et al. 2015

Critical Reviews in Food Science and Nutrition

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“…These GAG-like polysaccharides are present in several families of invertebrate animals from the phyla Cnidaria, Arthropoda, Mollusca, Echinodermata and Chordata. Generally, the GAG-like polysaccharides from marine sources contain high negative charge density due to the presence of sulfate or carboxyl groups in different positions [72,73,74,75]. In addition, unique structural modifications, such as glucose and sulfated fucose branches, which were rarely described in GAGs, are also found.…”

Section: Ms For Characterizing Gag-like Oligosaccharides From Marimentioning

confidence: 99%

Applications of Mass Spectrometry to Structural Analysis of Marine Oligosaccharides

et al. 2014

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Marine oligosaccharides have attracted increasing attention recently in developing potential drugs and biomaterials for their particular physical and chemical properties. However, the composition and sequence analysis of marine oligosaccharides are very challenging for their structural complexity and heterogeneity. Mass spectrometry (MS) has become an important technique for carbohydrate analysis by providing more detailed structural information, including molecular mass, sugar constituent, sequence, inter-residue linkage position and substitution pattern. This paper provides an overview of the structural analysis based on MS approaches in marine oligosaccharides, which are derived from some biologically important marine polysaccharides, including agaran, carrageenan, alginate, sulfated fucan, chitosan, glycosaminoglycan (GAG) and GAG-like polysaccharides. Applications of electrospray ionization mass spectrometry (ESI-MS) are mainly presented and the general applications of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) are also outlined. Some technical challenges in the structural analysis of marine oligosaccharides by MS have also been pointed out.

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“…A few well-known examples include hyaluronic acid (HA), chondroitin sulfate (CS)/dermatan sulfate (DS), and heparin (HP)/heparan sulfate. The presence of GAGs in some mollusks has now been well established but with variations in the relative amounts, molecular mass and sulfation (Cássaro & Dietrich, 1977;Chavante et al, 2000;Dietrich et al, 1985;Jordan & Marcum, 1986;Li et al, 2011;Luppi, Cesaretti, & Volpi, 2005;Nicola & Francesca, 2005, 2007, 2009Pejler et al, 1987;Volpi & Maccari, 2008). In addition, non-glycosaminoglycan polysaccharides with uronic acids are also identified (Wang, Jun, & Li, 2015).…”

Section: Introductionmentioning

confidence: 99%

Characterization of acidic polysaccharides from the mollusks through acid hydrolysis

Cao

Wen

et al. 2015

Carbohydrate Polymers

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A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: Purification, structure identification and anticoagulant activity

Cited by 59 publications

References 21 publications

Therapeutic potential of abalone and status of bioactive molecules: A comprehensive review

Therapeutic potential of abalone and status of bioactive molecules: A comprehensive review

Applications of Mass Spectrometry to Structural Analysis of Marine Oligosaccharides

Characterization of acidic polysaccharides from the mollusks through acid hydrolysis

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