A novel green approach for treatment of immature Schistosomiasis Mansoni infection in mice; Arabic gum (Acacia Senegal) antischistosomal properties

Abstract

Abstract. CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018; 26Schistosomiasis is one of the most socioeconomically exhausting parasitic 27 infection in tropical and subtropical areas. Praziquantel (PZQ), the only common 28 schistosocidal drug in use, is not efficient enough for treatment of immature infection. 29Arabic gum (AG) is a complex polysaccharide acts as anti-oxidant which modulates the Author summary 46Schistosomiasis is a major public health threat in many parts of the world, it 47 affects more than 240 million people in more than 70 countries and almost 800 million 48 people are at risk of acquiring this disease. Serious consequences and disabilities might . CC-BY 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint . http://dx.doi.org/10.1101/347278 doi: bioRxiv preprint first posted online Jun. 14, 2018;

The in Vitro Antischistosomal Activity and Genotoxicity of the Active Ingredients of Allium sativum (allicin) and Curcuma longa (curcumin)

“…in humans, and while the current drug of choice is praziquantel (PZQ) ( 4 ), PZQ efficacy has been reduced ( 5 – 7 ). Such drugs may be found in natural resources, for example in medicinal plants recommended for the treatment of schistosomiasis ( 8 – 11 ).…”

Structural, functional and docking analysis against Schistosoma mansoni dihydroorotate dehydrogenase for potential chemotherapeutic drugs

“…The public health impacts of schistosomiasis, caused by Schistosoma species, are second only to malaria in endemic regions and it is an important neglected tropical disease (NTD) 1,2 . More than 240 million people are infected with one or more Schistosoma species in the tropical or subtropical regions [2][3][4] . Approximately 85% of these infections occur in sub-Sahara Africa 3,4 .…”

“…More than 240 million people are infected with one or more Schistosoma species in the tropical or subtropical regions [2][3][4] . Approximately 85% of these infections occur in sub-Sahara Africa 3,4 . Movement of refugees and mass migration of individuals from endemic to non-endemic areas have recently expanded the areas at risk of schistosomiasis and increased disease prevalence in recent times [5][6][7] .…”

“…The control of this disease is solely dependent on the chemotherapeutic drug praziquantel, which is used to treat infected individuals. There is no effective vaccine currently 3,9 . Other chemotherapy alternatives include oxamniquine and metrifonate, although these have some setbacks, such as being ineffective against all life stages of the parasite and severe side effects, which is why praziquantel is recommended [10][11][12][13][14][15][16][17] .…”