A novel group of rhinoviruses is associated with asthma hospitalizations

Miller, E. Kathryn; Edwards, Kathryn M.; Weinberg, Geoffrey A.; Iwane, Marika K.; Griffin, Marie R.; Hall, Caroline Breese; Zhu, Yuwei; Szilâgyi, Peter G.; Morin, Laura-Lee; Heil, Luke; Lu, Xiaoyan; Williams, John V.

doi:10.1016/j.jaci.2008.10.007

Cited by 237 publications

(296 citation statements)

References 54 publications

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“…Interestingly, in the present pediatric study about 59.7% of picornaviruses infection cases are related to low respiratory tract infections (LRTIs) although these viruses are usually related to mild URTI. These results underline a need for picornaviruses investigation during viral diagnosis of respiratory tract diseases in light of recently published data regarding the association of rhinoviruses especially with severe respiratory tract infections in children [37][38][39], and in asthma exacerbations [16,[40][41][42].…”

Section: Authors' Contributionssupporting

confidence: 63%

Children under five years of age in senegal: A group highly exposed to respiratory viruses infections

Fall¹,

Dieng²,

Wade³

et al. 2017

Virol Res Rev

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Section: Authors' Contributionssupporting

confidence: 63%

Children under five years of age in senegal: A group highly exposed to respiratory viruses infections

Fall¹,

Dieng²,

Wade³

et al. 2017

Virol Res Rev

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“…Indeed, the sequencing results do not reflect the full spectrum of HRV/HEV strains that may be circulating in ILI patients in Senegal, and may be biased toward samples with a high viral load; and especially for HRV, systematic type identification of positive samples would allow to pick up seasonal differences among the individual HRV species in Senegal, as reported in studies conducted in other geographical areas. [49][50][51] In conclusion, the results of the present study suggest strong year-round respiratory picornavirus activity in children up to 5 years of age in Senegal. Molecular studies identified a wide variety of RVs along with CBV in samples from patients with ILI.…”

Section: Discussionmentioning

confidence: 53%

Enteroviruses and Rhinoviruses: Molecular Epidemiology of the Most Influenza-Like Illness Associated Viruses in Senegal

Fall

Dia

Kébé

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Different viruses have been identified as etiologic agents of respiratory tract infections, including severe cases. Among these, human rhinoviruses (HRVs) and human enteroviruses (HEVs) are recognized as leading causes. The present study describes the molecular epidemiology of HRVs and HEVs in Senegal over a 3-year surveillance period. From January 2012 to December 2014, nasopharyngeal and oropharyngeal swabs specimen were collected from patients with influenza-like illness (ILI). A real-time reverse transcription polymerase chain reaction was performed for HRV and HEV detection using the RV16 kit. Two regions were targeted for the molecular characterization of RVs: 5′ untranslated region (5′UTR) and viral protein 4/viral protein 2 (VP4/VP2) transition region. For enteroviruses (EVs) phylogeny, VP1 gene was targeted. A total of 4,194 samples were collected. Children up to 5 years accounted for 52.9%. Among them, 1,415 (33.7%) were positive for HRV, 857 (20.4%) for HEV, and 437 cases of dual infections HRV/HEV. HRVs and HEVs were identified significantly in children aged 5 years or less. Only cough and vomiting signs were observed with significant association with viral infection. Both viruses co-circulated all year long with a marked increase of activity during rainy and cold period. All HRV types circulate in Senegal. HRV-A and C groups were the most common. HEV serotyping identified coxsackie B viruses (CBV) only. VP1 region revealed different CBV (CBV1, CBV2, CBV3, CBV4, and CBV5), echoviruses, coxsackieviruses A4-like strains and a poliovirus 2. The results suggest strong year-round respiratory picornavirus activity in children up to 5 years of age. Molecular studies identified a wide variety of RVs along with diverse EVs in samples from patients with ILI.

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“…Febrile wheeze and asthma exacerbation were the commonest presentation (76%) of RV-C infection, whereas others have shown strong associations of this novel RV with bronchitis, bronchiolitis and pneumonia [48,49]. In a prospective study of preschool children hospitalised with acute respiratory illness or fever, RV-C infections accounted for 46% of RV-positive samples and were significantly associated with an asthma diagnosis at hospital discharge compared to patients with RV-A (55 versus 36%, respectively) [50]. This result has now been duplicated in various settings, suggesting that this novel group might cause a substantial burden in paediatric asthma [51][52][53].…”

Section: Infection Among Factors Precipitating Asthma Exacerbationsmentioning

confidence: 97%

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers: Figure 1–

Xepapadaki¹,

Papadopoulos²

2010

Eur Respir J

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Respiratory infections have been implicated in the origin and exacerbation of asthma in a variety of ways; however, systemisation of this knowledge in a way helpful for disease management remains suboptimal.Several conceptual issues need to be taken into account: the fact that the effects of an infection may vary according to genetic background, the current immune status of the host, and parallel environmental stimuli, in addition to the particular infectious agent itself. Moreover, childhood is a very special period because of the continuous processes taking place, such as neural, immune and respiratory maturation.Epidemiological studies have convincingly demonstrated that the majority of asthma exacerbations, in both adults and children, follow viral upper respiratory tract infections. Asthma exacerbations are still often unresponsive to current asthma treatment, and new therapeutic approaches are required.This review presents current knowledge on the associations between infection and exacerbation of established asthma with respect to definitions, epidemiology, mechanisms and treatment.

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A novel group of rhinoviruses is associated with asthma hospitalizations

Abstract: Overall, HRVCs were detected in 7% of children hospitalized for fever or respiratory conditions and constituted almost half of all rhinovirus-associated hospitalizations, suggesting that this novel group causes a substantial burden of pediatric disease.

Cited by 237 publications

References 54 publications

Children under five years of age in senegal: A group highly exposed to respiratory viruses infections

Children under five years of age in senegal: A group highly exposed to respiratory viruses infections

Enteroviruses and Rhinoviruses: Molecular Epidemiology of the Most Influenza-Like Illness Associated Viruses in Senegal

Childhood asthma and infection: virus-induced exacerbations as determinants and modifiers: Figure 1–

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