A novel HCV electrochemical biosensor based on a polyaniline@Ni-MOF nanocomposite

Sheta, Sheta M.; El‐Sheikh, Said M.; Osman, Diaa; Salem, A.M.S.; Ali, Omnia; Harraz, Farid A.; Shousha, Wafaa Gh.; Shoeib, Madiha A.; Shawky, Sherif M.; Dionysiou, Dionysios D.

doi:10.1039/d0dt01408g

Cited by 62 publications

(24 citation statements)

References 42 publications

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“…On the other hand, the nanomaterials generally and metal-organic frameworks in nano-size-scale (MOF-NPs) especially have many advantages and auspicious properties like chemical and thermal stability, porosity, large surface area, highly magnetic, excellent adsorbent materials …., etc. [23][24][25][26][27][28][29][30][31][32]. Different excellent physicochemical properties of the MOF-NPs make these nanomaterials are very sensitive and selective tools for bonding to biological and organic molecules and can be simply interacted moreeffective than bulk state materials [33].…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen

El‐Sheikh

2021

Preprint

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PSA, abbreviated of “Prostate-Specific Antigen” is widely used as a considered a significant cancer biomarker for diagnosing prostate cancer. Improvement of a fast, facile, and less cost with high accurate/sensitive/selective methodologies for the PSA determination is stock-still a challenge. In this work, we reported a simple biosensor based on a Zn(II) metal-organic framework nanoparticles (Zn-MOF-NPs) derived from reaction of zinc acetate with nano organic linker. The structure, morphology, and physicochemical properties of the prepared Zn(II)-MOF-NPs were definite using various spectroscopic and microanalytical tools as SEM-EDX, HR-TEM, XRD, XPS, elemental analysis, FT-IR, UV-vis spectroscopy, mass spectroscopy, thermogravimetric Analysis (DSC/TGA), and photoluminescence (PL). Obviously, the results revealed that the Zn(II)-MOF-NPs is chemical stable, highly selective and sensitive to PSA, without interferences with other common interfering analytes. The detection limit for PSA was 0.145 fg/mL, in a wide-linear range of concentrations (0.1 fg/mL-20 pg/mL), with a correlation coefficient 0.983. The Zn(II)-MOF-NPs was successfully used as an up-and-coming biosensor for PSA-monitoring and quantification in biological real samples (plasma/whole blood/serum) at clinical target concentration levels. Moreover, the present approach will help the human-beings from the hazard’s prostatic cancer through early discovery and diagnosis process via the detection of PSA at low limits of concentrations. Meantime, the interaction mechanism between the Zn(II)-MOF-NPs and PSA was well studied and investigated.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen

El‐Sheikh

2021

Preprint

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“…† The peaks at 3400, 3310, 2973, and 1131 cm À1 are due to NH 2 , O-H, C-H and C-O stretching of ethanol molecules. 26,27 The peak at 3210 cm À1 is assigned to the stretching of N-H. The sharp bands between 1525 and 1485 cm À1 are due to the stretching of C]C. 28,29 The bands between 1129 and 1055 cm À1 are attributed to C-H.…”

Section: Nano-lanthanum Complex Characterizationmentioning

confidence: 99%

A novel nano-lanthanum complex: synthesis, characterization and application as a macrofuran chemosensor in pharmaceutical, biological and environmental samples

2021

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“…MOFs synthesized by suitable strategy with desired properties led to different biomedical applications, as mentioned earlier. Also MOFs with tunable characteristics could be applied in separation [65,66,67], catalysis [68,69,70], sensing [71,72,73,74,75,76,77], and storage [78,79,80,81].…”

Section: Biodegradabilitymentioning

confidence: 99%

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review

Ahmadi

Ayyoubzadeh

Ghorbani‐Bidkorbeh

et al. 2021

Heliyon

101

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Metal-organic frameworks (MOFs) are a fascinating class of crystalline porous materials composed of metal ions and organic ligands. Due to their attractive properties, MOFs can potentially offer biomedical field applications, such as drug delivery and imaging. This study aimed to systematically identify the affecting factors on the MOF characteristics and their effects on structural and biological characteristics. An electronic search was performed in four databases containing PubMed, Scopus, Web of Science, and Embase, using the relevant keywords. After analyzing the studies, 20 eligible studies were included in this review. As a result, various factors such as additives and organic ligand can influence the size and structure of MOFs. Additives are materials that can compete with ligand and may affect the nucleation and growth processes and, consequently, particle size. The nature and structure of ligand are influential in determining the size and structure of MOF. Moreover, synthesis parameters like the reaction time and initial reagents ratio are critical factors that should be optimized to regulate the size and structure. Of note is that the nature of the ligand and using a suitable additive can control the porosity of MOF. The more extended ligands aid in forming large pores. The choice of metallic nodes and organic ligand, and the MOF concentration are important factors since they can determine toxicity and biocompatibility of the final structure. The physicochemical properties of MOFs, such as hydrophobicity, affect the toxicity of nanoparticles. An increase in hydrophobicity causes increased toxicity of MOF. The biodegradability of MOF, as another property, depends on the organic ligand and metal ion and environmental conditions like pH. Photocleavable ligands can be served for controlled degradation of MOFs. Generally, by optimizing these affecting factors, MOFs with desirable properties will be obtained for biomedical applications.

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A novel HCV electrochemical biosensor based on a polyaniline@Ni-MOF nanocomposite

Abstract:
A novel label-free electrochemical biosensor constructed using a polyaniline@nickel metal–organic framework (Ni-MOF) nanocomposite for direct detection of HCV-RNA.

Cited by 62 publications

References 42 publications

WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen

WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen

A novel nano-lanthanum complex: synthesis, characterization and application as a macrofuran chemosensor in pharmaceutical, biological and environmental samples

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review

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A novel HCV electrochemical biosensor based on a polyaniline@Ni-MOF nanocomposite

Abstract: A novel label-free electrochemical biosensor constructed using a polyaniline@nickel metal–organic framework (Ni-MOF) nanocomposite for direct detection of HCV-RNA.

Cited by 62 publications

References 42 publications

WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen

WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen

A novel nano-lanthanum complex: synthesis, characterization and application as a macrofuran chemosensor in pharmaceutical, biological and environmental samples

An investigation of affecting factors on MOF characteristics for biomedical applications: A systematic review

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Abstract:
A novel label-free electrochemical biosensor constructed using a polyaniline@nickel metal–organic framework (Ni-MOF) nanocomposite for direct detection of HCV-RNA.