A novel herbal formulation versus chlorhexidine mouthwash in efficacy against oral microflora

Abstract

Aims and Objectives:The aim of the study was to compare and to analyze the antimicrobial efficacy of 0.12% chlorhexidine and new formulated herbal mouthwash after using for 14 days. The objective was to signify whether the noval herbal combination could be a better alternative mouthwash to Chlorhexidine (CHX).Materials and Methods:This is a double-blinded, random controlled research study conducted in the Department of Oral Pathology and Microbiology. A total of 200 dental students were selected randomly, comprising of two groups, 100 in each, aged between 18 and 22 years with gingival index of score II. The first group was advised to oral rinse with 0.12% chlorhexidine mouthwash and the second group with new formulated herbal mouthwash for 14 days. Saliva samples were collected on the day 0 (baseline), followed by day 7 and 14 and microbial colony count was performed. The data obtained was statistically analyzed using SPSS version 16. Student's t-test was applied for comparison of the mean microbial count between the two groups. Repeated measures analysis of variance followed by Tukey's post hoc test was applied to assess the changes from day 0 to day 7 to day 14. The statistical significance level was set at P < 0.05.Results:Microbial colonies were reduced better in chlorhexidine group on the day 7 whereas, on day 14, greater reduction was observed in the herbal group in both gender groups with high statistical significance (P < 0.001).Conclusions:Herbal mouthwash formulation performed effectively well on long-term usage, could be used as an alternative mouthwash to overcome the disadvantages of chlorhexidine.

Comparative Evaluation of Chlorhexidine and Sodium Hexametaphosphate Mouth Rinses on Dental Plaque in Children: A randomized clinical trial.

“…The mean value of Lactobacillus count in both group I and group II showed a highly statistically significant decrease from 7 days to 15 days and from baseline to 15 days as shown in table (4) and figures (5,6).…”

“…Tooth discoloration, sensitivity changes, taste perturbation, unilateral, or bilateral parotid swelling and tongue pain may occur as side effects leading to search for new formulations. (6) The addition of inorganic polyphosphate salts (including sodium hexametaphosphate) to fluoridated products has been shown to be effective in increasing their effectiveness against caries. (7) Sodium hexametaphosphate (SHMP) is able to inhibit the formation of dental calculus, (8) has antimicrobial action (9) and also prevents the formation of extrinsic stains.…”

Antibacterial Efficacy of Conventional Versus Herbal Products on Streptococcus mutans in Adult Population- a Systematic Review & Meta-analysis

“…Among the 12 included studies, [7,[28][29][30][31][32][33][34][35][36][37][38] only five [7,30,32,36,37] were considered for meta-analysis. Only studies, which provided baseline and post-analysis data (Mean & S.D), were only considered.…”

“…Vinod KS et al [36], study compared chlorhexidine with formulated herbal mouthwash (tulsi, neem, triphala, turmeric). chlorhexidine showed 20.94%, 60.74% at 7th and 14th day, herbal group showed 28.94%, 40.64% at 7th and 14th days, in a sample of 100.…”

Effect of powdered green tea matcha on biofilm formation by mutans Streptococci

“…The better antibacterial will suppress more types of strains, meanwhile caries are not only caused by a single bacterial but related to the biofilm activity involving many bacteria [23]. Chlorhexidine is a common ingredient as an antibacterial agent and is widely used for mouthwashes [24][25][26][27][28]. However, chlorhexidine has a taste issue, and it has problems such as side effects on the mucosa and tooth coloring, so it is not suitable for mouthwashes in children [29,30].…”