A Novel Herbal Medicine for Dyslipidemia: Assessments in Experimental Models

Abstract

Dyslipidemia substantially contributes to the risk of cardiovascular diseases. The polyherbal formulation has been a traditional therapeutic strategy used to treat dyslipidemia. This study was designed to evaluate the effects of a novel herbal medicine called “GANMO” on an experimental animal model with endogenous dyslipidemia and exogenous dyslipidemia. In the endogenous hyperlipidemia model, rats were previously treated with GANMO tablets and intraperitoneally injected with poloxamer 407 to induce hyperlipidemia. In the exogenous hyperlipidemia model, rats were given oral administration of oil-cholesterol mixture and GANMO for 4 consecutive weeks. Serum lipid profiles were assessed at all experimental animals. In both models, GANMO at both doses significantly decreased the serum total cholesterol (TC) level and non-high-density lipoprotein (HDL) cholesterol level as compared with the model group. HDL cholesterol levels increased in rats with high doses of GANMO compared to those with low doses. GANMO at both doses substantially reduced TG level in the endogenous hyperlipidemia model. In conclusion, GANMO tablets posed a positive effect on serum lipid modulations in dyslipidemia models.

A Topical Botanical Ointment for Self-Reported Hip and/or Knee Pain: A Randomized Placebo-Controlled Clinical Trial

“…8,9 Despite the popularity of existing topicals, some individuals may prefer treatment options that are all-natural, with origins in botanical medicine. For example, the market for herbal medicine is anticipated to be six to seven times the 2019 market by 2030, as more people turn to all-natural herbal-based medicines for a variety of health benefits, 10 including antioxidant, 11 anti-inflammatory, 12 blood glucose 13 and lipid-lowering activities, 14 in addition to improved sleep 15 and cognitive performance. 16 The healthcare market for natural products is prevalent worldwide in both developing and developed countries alike.…”