A novel herbal treatment reduces depressive-like behaviors and increases BDNF levels in the brain of stressed mice

Doron, Ravid; Lotan, Dafna; Einat, Nili; Yaffe, Roni; Winer, Avigail; Marom, Inbal; Meron, G.; Kately, Nadav; Rehavi, Moshe

doi:10.1016/j.lfs.2013.10.025

Cited by 36 publications

(33 citation statements)

References 48 publications

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“…Previous studies have shown the therapeutic effects of some Traditional Chinese Medicine in the treatment of depression 6,7. The antidepressant effect of the ethanol extract of Radix Puerariae has been reported in mice exposed to cerebral ischemia reperfusion6 and in C57BL/6 N mice with spared nerve injury,8 and the hawthorn fruit is a promising remedy in the treatment of anxiety9 and has also been reported to reduce depressive-like behaviors in mice with chronic mild stress 7. Furthermore, a possible mechanism of reducing depression is increasing brain-derived neurotrophic factor (BDNF) levels 10.…”

Section: Introductionmentioning

confidence: 99%

A novel herbal treatment reduces depressive-like behaviors and increases brain-derived neurotrophic factor levels in the brain of type 2 diabetic rats

Luo

Yuan

et al. 2016

NDT

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BackgroundRadix Puerariae and hawthorn fruit have been demonstrated to treat diabetes. They offer potential benefits for preventing depression in diabetes.ObjectiveThe aim of this study was to investigate whether the combination of Radix Puerariae and hawthorn fruit (CRPHF) could prevent depression in a diabetic rat model generated by feeding the rats with a high-fat diet and a low-dose streptozotocin (STZ).MethodsThe CRPHF was provided by the Shanghai Chinese Traditional Medical University. Twenty-four rats were randomly divided into four groups: normal control, normal-given-CRPHF (NC), diabetic control, and diabetic-given-CRPHF (DC) groups. The type 2 diabetic model was created by feeding the rats with a high-fat diet for 4 weeks followed by injection of 25 mg/kg STZ. CRPHF was given at 2 g/kg/d to the rats of NC and DC groups by intragastric gavage daily for 4 weeks after the type 2 diabetic model was successfully created. Body weight, random blood glucose (RBG), oral glucose tolerance test, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured during the study. Depressive-like behavior was evaluated at the end of the treatment by using the open field test (OFT), the elevated plus-maze test (EPMT), locomotor activity test (LAT), and forced swimming test (FST). Levels of extracellular signal-regulated protein kinase (ERK) and brain-derived neurotrophic factor (BDNF) in the prefrontal cortex were evaluated by using Western blot.Results1) CRPHF reduced RBG and improved glucose tolerance in diabetic rats; 2) CRPHF reduced TC and TG but did not significantly change HDL-C or LDL-C in diabetic rats; 3) CRPHF reversed the loss in body weights observed in diabetic rats; 4) CRPHF reduced depressive-like behavior as measured by OFT, EPMT, LAT, and FST; 5) BDNF was upregulated, and ERK was activated in the prefrontal cortex of diabetic rats treated with CRPHF.ConclusionCRPHF has the potential of preventing depression in patients with diabetes.

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Section: Introductionmentioning

confidence: 99%

A novel herbal treatment reduces depressive-like behaviors and increases brain-derived neurotrophic factor levels in the brain of type 2 diabetic rats

Luo

Yuan

et al. 2016

NDT

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“…La serotonina, por ejemplo, parece mediar varios de los efectos antidepresivos del ejercicio (Helmich et al, 2010;Sigwalt et al, 2011). Se ha reportado que la fluoxetina ocasiona aumento tanto en la supervivencia y proliferación neuronal Guirado et al, 2012;Hotting & Roder, 2013;Ivy, Rodriguez, Garcia, Chen & Russo-Neustadt, 2003;Manev, Uz, Smalheiser & Manev, 2001;Zusso et al, 2008) como en los niveles de BDNF (Doron et al, 2014;Ivy et al, 2003;Ladea & Bran, 2013;Quesseveur et al, 2013). Asimismo, existen algunos efectos indirectos del ejercicio físico sobre el estatus cognoscitivo de pacientes con enfermedad de Alzheimer (Cotman, Berchtold & Christie, 2007) o en envejecimiento en general (Rogers, Meyer & Mortel, 1990) y posiblemente uno de los mecanismos por los cuales se ejerce este efecto es el aumento del BDNF hipocampal (Cui, Hofer, Rani, Leeuwenburgh & Foster, 2009;Eyre & Baune, 2012;Hotting & Roder, 2013;Knochel et al, 2012;Macrae, Spirduso, Walters, Farrar & Wilcox, 1987).…”

Section: Enriquecimiento Ambiental Ejercicio Y Actividad Físicaunclassified

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Zarate¹,

Parra²,

Acevedo-Triana

et al. 2014

Univ Psychol

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r e S u M e n Grandes esfuerzos han sido llevados a cabo para entender los componentes psicobiológicos del estrés y de algunas de las psicopatologías relacionadas con él, tales como los trastornos de ansiedad (ansiedad generalizada o crisis de pánico) e incluso la depresión. Existen evidencias de que procesos como la neurogénesis y la plasticidad se ven enormemente afectados por muchos factores, entre ellos el estrés. En esta revisión se presentan algunos de los principales conceptos sobre la relación entre estrés, plasticidad y neurogé-nesis, a los que se ha llegado a partir de investigaciones realizadas -principalmente en modelos animales-, desde hace algunas décadas. Se realizará una diferenciación entre los efectos ocasionados por estrés crónico y agudo, tratando de establecer las interacciones que sobre estos efectos ejercen algunas variables tales como el género o el rango de edad, se enfatizarán los efectos comportamentales para finalmente revisar algunas de las formas de intervención actualmente más usadas para el tratamiento del estrés. Palabras clave estrés; plasticidad; neurogénesis a B S t r a C tThere is a growing interest in the comprehension of psychobiological mechanisms underlying stress and its relationships with many psychopathologies such as anxiety (i.e. generalized anxiety and panic attacks) or depression. There are several reports on the effects of stress on neurogenesis and plasticity. This review will discuss some of the core concepts on the relation between stress, plasticity and neurogenesis obtained during the last decades from research -mainly based in the use of animal models. The distinguishable effects between acute and chronic stress will also be discussed in relation to other factors as genre and age with an emphasis on behavioral effects. Some current therapeutic approaches will be reviewed as well.

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“…A reduced expression of BDNF in different brain areas (hippocampus, prefrontal cortex, substantia nigra) was detected in a plenty of animal models of depression including Olfactory Bulbectomy (OBX) and Unpredictable Chronic Mild Stress (UCMS) [99][100][101] as well as in genetic models of depression such as Flinders Sensitive Line [102] and Wistar-Kyoto rat strain [103]. Also, patients with MDD showed lower BDNF mRNA levels and plasma levels compared with healthy controls [104][105][106].…”

Section: Brain-derived Neurotrophic Factor (Bdnf)mentioning

confidence: 99%

“…Indeed, it has been reported that chronic treatment with different classes of antidepressants (SSRIs fluoxetine and escitalopram, MAOIs tranylcypromine and phenelzine, TCA desipramine) increases BDNF brain levels [101,[110][111][112][113]. A very recent study reported that long-term administration of the SSRI escitalopram to mice, experiencing postnatal maternal separation plus 4 weeks of UCMS in adolescence, induced an elevation of BDNF levels in the hippocampus [114].…”

Section: Brain-derived Neurotrophic Factor (Bdnf)mentioning

confidence: 99%

Neuroadaptations of the 5-HT System Induced by Antidepressant Treatments: Old and New Strategies

Haddjeri¹

2014

AAD

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Major Depressive Disorder (MDD) is a common illness worldwide with severe socioeconomic consequences. Several hypotheses have been formulated to explain the physiopathology of depression as well as the mechanism of action of antidepressants but two of them had attracted much attention. The dominant monoaminergic hypothesis of depression links the physiopathology of MDD to a deficiency on cerebral serotonin (5-HT) and/or Norepinephrine (NE) levels; however, the relatively new neurogenic and neurotrophic hypothesis raises the possibility of an impaired neuroplasticity and/or depletion of neurotrophic factors in specific networks resulting on their structural deformity and functional impairment. An enormous body of evidence reported particular neuroadaptations following chronic administration of antidepressant drugs. In this review, we describe major adaptive changes in pre-and post-synaptic 5-HT neurotransmission as well as alterations in gene transcription and neurotrophic factors in response to long-term treatment with conventional antidepressants, new putative ones or novel promising drug candidates, all acting via 5-HT system.

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A novel herbal treatment reduces depressive-like behaviors and increases BDNF levels in the brain of stressed mice

Cited by 36 publications

References 48 publications

A novel herbal treatment reduces depressive-like behaviors and increases brain-derived neurotrophic factor levels in the brain of type 2 diabetic rats

A novel herbal treatment reduces depressive-like behaviors and increases brain-derived neurotrophic factor levels in the brain of type 2 diabetic rats

Efectos del estrés sobre los procesos de plasticidad y neurogénesis: una revisión

Neuroadaptations of the 5-HT System Induced by Antidepressant Treatments: Old and New Strategies

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