2007
DOI: 10.1038/cr.2007.35
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A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses

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Cited by 253 publications
(208 citation statements)
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References 28 publications
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“…IL-17F is a proinflammatory cytokine with functions initially reported as similar to those of IL-17A and sharing the same receptor (45). Recent studies have revealed that IL-17A and IL-17F can be expressed as homo-or heterodimers that may bind IL-17 receptors with various affinities and may play not completely redundant functions (26,46,47). We found expression of IL-17F in only a fraction of IL-17A-secreting cells from NTreg, indicating the existence of distinct subpopulations that differentially express these cytokines and may be functionally distinct, an observation that warrants further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…IL-17F is a proinflammatory cytokine with functions initially reported as similar to those of IL-17A and sharing the same receptor (45). Recent studies have revealed that IL-17A and IL-17F can be expressed as homo-or heterodimers that may bind IL-17 receptors with various affinities and may play not completely redundant functions (26,46,47). We found expression of IL-17F in only a fraction of IL-17A-secreting cells from NTreg, indicating the existence of distinct subpopulations that differentially express these cytokines and may be functionally distinct, an observation that warrants further investigation.…”
Section: Discussionmentioning
confidence: 99%
“…Recently, human and mouse IL-17A and IL-17F have been reported to exist as a heterodimer (23,24). The regulation of IL-17F/A expression by Th17 cells and its expression relative to IL-17A/A and IL-17F/F have not been reported.…”
Section: Il-17a/a Il-17f/a and Il-17f/f Are Differentially Expressementioning
confidence: 99%
“…Mass spectrometry analysis of natural IL-17F/A heterodimer produced by primary human CD4 ϩ T cells has shown the existence of interchain disulfide-linked peptides containing a peptide from IL-17F and one from IL-17A (23). More recently, mouse IL-17F/A has been detected in conditioned medium from Th17 cells (24). While detected, the regulation of IL-17F/A expression and its in vivo functions have not been evaluated.…”
mentioning
confidence: 99%
“…Thus, although IL-17A À/À animals develop exacerbated dextran sulphate sodium colitis compared with WT controls, IL-17F À/À mice display reduced disease with greatly diminished cell infiltrates in the LP. 40 Besides IL-17A and IL-17F homodimers, there are also reports of IL-17F/A heterodimers, 32,42,43 adding to the complexity by which these cytokines exert their effects on target cells. Assuming complete in vivo neutralization by the antieIL-17A and antieIL-17F mAbs used in the present study, one may deduce from our findings that the tissue-protective effect revealed by the antieIL-17A mAb is because of homodimeric IL-17A, and not IL-17F/A heterodimers.…”
Section: Th17 Cytokines In H Hepaticus Colitismentioning
confidence: 99%