A novel histological grading system for minor salivary gland involvement in oral submucous fibrosis patients with clinico-pathological validation

Ingle, Yashwant; Sarode, Gargi S; Sarode, Sachin C.

doi:10.1016/j.jobcr.2021.09.003

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…In terms of MSG flow rate, there were statistically significant variations between grades I and II and grades I and III. MSG involvement in grades I and III fibrosis, on the other hand, did not differ statistically significantly, which was in accordance with a study done by Ingle et al [12]; a comparison was made between the MSG flow rate and a suggested grading system for the MSG's cooperation with OSMF. As the degree of MSG engagement with fibrosis grew, there was a noticeable tendency toward a decreased flow rate.…”

Section: Discussionsupporting

confidence: 91%

“…The reason for the differences in findings was that the staging method that was employed in research by Khanna and Andrade (1995) [ 18 ] was unique in comparison to the staging systems used in other investigations. In the research carried out by Ingle et al [ 12 ], it was shown that the CODS value rose when there was a higher level of MSG engagement with OSMF. This was one of the findings of the research.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Histological Changes in the Structure of the Minor Salivary Glands in Patients With Oral Submucous Fibrosis (OSMF)

Patel¹,

Abdul²,

Vala³

et al. 2022

Cureus

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Background: The minor salivary glands (MSGs) are critical components of the mouth's delicate environment. The pre-malignant changes of oral submucous fibrosis (OSMF) have been associated with a decline in the quality of life and an uptick in the prevalence of oral malignancies.Aim: The aim was to provide evidence of the histological alterations in minor salivary gland structure seen in individuals with OSMF.Methods and materials: A total of 106 confirmed cases of OSMF were enrolled in the study. In order to perform an incisional biopsy, we first collected the patient's complete demographic and clinical history.Using a Vernier calliper, the inter-incisal distance was used to evaluate the mouth opening of the patients. An incisional biopsy of the buccal mucosa was carried out using a 6 mm diameter punch and local anaesthesia. After the appropriate demographic and medical information had been gathered. Acinar cells and the surrounding stroma of tissue slices were observed under a light microscope for alterations. The cytoplasm, nucleus morphology, cellular shape, mucin pooling, and acinar outline of acinar cells were all examined by the researchers. It was taken into account to classify OSMF histologically based on variations in juxta epithelial hyalinization.Results: Multiple aetiologies for the symptoms of OSMF were reflected in the patient's histological abnormalities in the minor salivary glands. On the measurement of the diameter of acini, we discover that the average area of salivary gland acini in OSMF patients is smaller than in the normal group indicative of a decrease in size. The number of functional acini in OSMF is fewer than compared in the control group.Conclusion: Because of the findings of this study, we now have a better understanding of the factors that play a role in the incidence of dryness of the oral and pharyngeal mucosa (OSMF), although it has to be mentioned that no major impact of OSMF on minor salivary glands was observed in our study.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Evaluation of the Histological Changes in the Structure of the Minor Salivary Glands in Patients With Oral Submucous Fibrosis (OSMF)

Patel¹,

Abdul²,

Vala³

et al. 2022

Cureus

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“… 12 To the best of our knowledge, this is the first study to report and quantify the hygroscopicity of BQ when mixed with saliva, and this forms a proof of concept for future implications in the pathogenesis of various oral pathologies. We propose that BQ hygroscopicity might have a role in some reported OSMF events such as minor salivary gland hypofunction, 13 diminished reactive adiopogenesis, 14 dysfunctional myoepithelial cells, 15 and matrix stiffness. 16 It is premature to draw any conclusion regarding the pathogenic mechanism, however BQ hygroscopicity would act as complementary to the already known mechanisms of OSMF.…”

Section: Resultsmentioning

confidence: 93%

Quantification of betel quid hygroscopicity in context to saliva: A proof of concept for future studies

Sarode

Sharma

Sarode

et al. 2023

Journal of Oral Biology and Craniofacial Research

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Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities

Marinkovic,

Tran,

Wang

et al. 2023

Journal of Oral Biology and Craniofacial Research

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A novel histological grading system for minor salivary gland involvement in oral submucous fibrosis patients with clinico-pathological validation

Cited by 6 publications

References 20 publications

Evaluation of the Histological Changes in the Structure of the Minor Salivary Glands in Patients With Oral Submucous Fibrosis (OSMF)

Evaluation of the Histological Changes in the Structure of the Minor Salivary Glands in Patients With Oral Submucous Fibrosis (OSMF)

Quantification of betel quid hygroscopicity in context to saliva: A proof of concept for future studies

Extracellular matrix turnover in salivary gland disorders and regenerative therapies: Obstacles and opportunities

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