A novel hydrogel-based combination therapy for effective neuroregeneration after spinal cord injury

Wang, Qingqing; Dong, Xiaoyu; Zhang, Hongyu; Li, Peifeng; Lu, Xiaojie; Wu, Min; Zhang, Weiqi; Lin, Xianfeng; Zheng, Yixin; Mao, Yuqing; Zhang, Jing; Ying, Lin; Chen, Xiangxiang; Chen, Dingwen; Wang, Jian; Xiao, Jian

doi:10.1016/j.cej.2021.128964

Cited by 20 publications

(13 citation statements)

References 65 publications

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“…The main goal of treatment is to improve the terrible microenvironment at the site of SCI and promote neuronal growth and differentiation, which has also been demonstrated in recent studies ( Ashammakhi et al, 2019 ; Bellák et al, 2020 ) ( Figure 3 ). For example, cytokines such as fibroblast growth factor-2 (FGF2) ( Xu et al, 2018 ), glial cell-derived neurotrophic factor (GDNF) ( Zhu et al, 2015 ), basic fibroblast growth factor (bFGF) ( Wang et al, 2021a ), brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) ( Wen et al, 2016 ) have often been used for SSCI treatment. These active materials are beneficial to nerve cell growth and vessel regeneration.…”

Section: Treatment Strategies Of Hydrogels As Scaffolds and Delivery ...mentioning

confidence: 99%

Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

Peng

Liu

Xiao

et al. 2023

Front. Bioeng. Biotechnol.

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Secondary spinal cord injury (SSCI) is the second stage of spinal cord injury (SCI) and involves vasculature derangement, immune response, inflammatory response, and glial scar formation. Bioactive additives, such as drugs and cells, have been widely used to inhibit the progression of secondary spinal cord injury. However, the delivery and long-term retention of these additives remain a problem to be solved. In recent years, hydrogels have attracted much attention as a popular delivery system for loading cells and drugs for secondary spinal cord injury therapy. After implantation into the site of spinal cord injury, hydrogels can deliver bioactive additives in situ and induce the unidirectional growth of nerve cells as scaffolds. In addition, physical and chemical methods can endow hydrogels with new functions. In this review, we summarize the current state of various hydrogel delivery systems for secondary spinal cord injury treatment. Moreover, functional modifications of these hydrogels for better therapeutic effects are also discussed to provide a comprehensive insight into the application of hydrogels in the treatment of secondary spinal cord injury.

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Section: Treatment Strategies Of Hydrogels As Scaffolds and Delivery ...mentioning

confidence: 99%

Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

Peng

Liu

Xiao

et al. 2023

Front. Bioeng. Biotechnol.

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“…When a single drug is combined with a pathway, it may not be sufficient to achieve tumor regression. [141][142][143] Using a combination chemotherapy strategy, two (or more) agents working against the same cancer path, gene, or cell cycle checkpoint are combined with increasing its chance of being eliminated. Oncologists can reduce cytotoxic effects by combining chemotherapeutic medications, which increase efficacy while reducing cytotoxic effects.…”

Section: Combination Therapymentioning

confidence: 99%

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Zare¹,

Taheri‐Ledari²,

Esmailzadeh³

et al. 2023

Nanoscale

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“…These can be loaded in a liposome (LIP) with a silk fibroin (SF) hydrogel core (SLIP) for their simultaneous release ( Figure 6 ). This combination therapy was shown to have the ability to ameliorate various key pathological mechanisms [ 173 ]. Indeed, docetaxel is able to promote microtubule stabilization and stimulate axonal growth, while FGF can reduce the cavity area and neuronal loss, creating a good environment for neuroregeneration.…”

Section: Drug Delivery To the Spinal Cord: The Role Of Biomaterials I...mentioning

confidence: 99%

“… Schematic diagram of the injectable liposome–silk fibroin composite hydrogel as an in situ multiple drug delivery system for the treatment of SCI. Reprinted with permission from [ 173 ]. …”

Section: Figurementioning

confidence: 99%

Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment

et al. 2022

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Spinal cord injury (SCI) is an injurious process that begins with immediate physical damage to the spinal cord and associated tissues during an acute traumatic event. However, the tissue damage expands in both intensity and volume in the subsequent subacute phase. At this stage, numerous events exacerbate the pathological condition, and therein lies the main cause of post-traumatic neural degeneration, which then ends with the chronic phase. In recent years, therapeutic interventions addressing different neurodegenerative mechanisms have been proposed, but have met with limited success when translated into clinical settings. The underlying reasons for this are that the pathogenesis of SCI is a continued multifactorial disease, and the treatment of only one factor is not sufficient to curb neural degeneration and resulting paralysis. Recent advances have led to the development of biomaterials aiming to promote in situ combinatorial strategies using drugs/biomolecules to achieve a maximized multitarget approach. This review provides an overview of single and combinatorial regenerative-factor-based treatments as well as potential delivery options to treat SCIs.

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A novel hydrogel-based combination therapy for effective neuroregeneration after spinal cord injury

Cited by 20 publications

References 65 publications

Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

Research progress of hydrogels as delivery systems and scaffolds in the treatment of secondary spinal cord injury

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Biomaterial-Mediated Factor Delivery for Spinal Cord Injury Treatment

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