A novel IMU-based clinical assessment protocol for Axial Spondyloarthritis: a protocol validation study

Abstract

Clinical assessment of spinal impairment in Axial Spondyloarthritis is currently performed using the Bath Ankylosing Spondylitis Metrological Index (BASMI). Despite being appreciated for its simplicity, the BASMI index lacks sensitivity and specificity of spinal changes, demonstrating poor association with radiographical range of motion (ROM). Inertial measurement units (IMUs) have shown promising results as a cost-effective method to quantitatively examine movement of the human body, however errors due to sensor angular drift have limited their application to a clinical space. Therefore, this article presents a wearable sensor protocol that facilitates unrestrained orientation measurements in space while limiting sensor angular drift through a novel constraint-based approach. Eleven healthy male participants performed five BASMI-inspired functional movements where spinal ROM and continuous kinematics were calculated for five spine segments and four spinal joint levels (lumbar, lower thoracic, upper thoracic and cervical). A Bland–Altman analysis was used to assess the level of agreement on range of motion measurements, whilst intraclass correlation coefficient (ICC), standardised error measurement, and minimum detectable change (MDC) to assess relative and absolute reliability. Continuous kinematics error was investigated through root mean square error (RMSE), maximum absolute error (MAE) and Spearman correlation coefficient (ρ). The overall error in the measurement of continuous kinematic measures was low in both the sagittal (RMSE = 2.1°), and frontal plane (RMSE = 2.3°). ROM limits of agreement (LoA) and minimum detectable change were excellent for the sagittal plane (maximum value LoA 1.9° and MDC 2.4°) and fair for lateral flexion (overall value LoA 4.8° and MDC 5.7°). The reliability analysis showed excellent level of agreement (ICC > 0.9) for both segment and joint ROM across all movements. The results from this study demonstrated better or equivalent accuracy than previous studies and were considered acceptable for application in a clinical setting. The protocol has shown to be a valuable tool for the assessment of spinal ROM and kinematics, but a clinical validation study on Axial Spondyloarthritis patients is required for the development and testing of a novel mobility index.

A Wearable System Based on Multiple Magnetic and Inertial Measurement Units for Spine Mobility Assessment: A Reliability Study for the Evaluation of Ankylosing Spondylitis

“…Regarding the validity and accuracy of the system, the registered ranges of motion are consistent with the literature on spinal biomechanics [46][47][48] and similar to those reported by Franco et al [33]. Even so, further study is needed to assess the accuracy of the system.…”

“…They studied the trunk flexion/extension, trunk lateral flexion, and rotation (not including measures of cervical mobility) under supervised and unsupervised conditions; they also calculated a normalized index IMU-ASMI and evaluated its reliability. Franco et al [33] evaluated five movements, trunk flexion, trunk extension, trunk lateral flexion, cervical rotation, and cervical flexion/extension, using five commercial inertial sensors. Gardiner et al [34] evaluated the maximum range of motion at the cervical and lumbar spine with two ViMove brand inertial sensors.…”

Inter-rater and intra-rater reliability of isotonic exercise monitoring device for measuring active knee extension

“…4 , a triaxial accelerometer ( g range) of the isotonic exercise monitor was strapped around the right ankle of the subject and then sampled at 100 Hz. The roll ( ) and pitch ( ) angles ( Narkhede et al, 2021 ; Franco et al, 2021 ) were then calculated using the following equations:…”

Computer-vision aided functional movement measurement in people with and without axial spondyloarthritis – validation and feasibility study protocol

“…The UCOASMI is an index of tests measured by automated motion capture using four cameras and 33 reflective markers placed on anatomical landmarks 9,10 . Even more recently, inertial measurement unit (IMU) sensor based systems have been used to measure spinal mobility in the axSpA population using five IMUs mounted along the spine to measure spinal mobility 11,12 .…”