A novel indicator for surveillance colonoscopy following colorectal cancer resection

Skaife, Paul; Seow‐Choen, Francis; Eu, Kong‐Weng; Tang, Choong Leong

doi:10.1046/j.1463-1318.2003.00379.x

Cited by 22 publications

(14 citation statements)

References 16 publications

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“…In four cases the cancer was a local recurrence and in five it was a metachronous cancer. 7 The lesions that we detected may have been missed or may have been rapidly developing lesions. A miss rate for significant adenomas (polyps >10 mm) has been demonstrated to be as high as 8%, and up to 15% for adenomas greater than 5 mm.…”

Section: Discussionmentioning

confidence: 91%

Interval faecal occult blood testing in a colonoscopy based screening programme detects additional pathology

Bampton

2005

Gut

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Background: Colonoscopic based surveillance is recommended for patients at increased risk of colorectal cancer. The appropriate interval between surveillance colonoscopies remains in debate, as is the ''miss rate'' for colorectal cancer within such screening programmes. Aims: The main aim of this study was to determine whether a one-off interval faecal occult blood test (FOBT) facilitates the detection of significant neoplasia within a colonoscopic based surveillance programme. Secondary aims were to determine if invitees were interested in participating in interval screening, and to determine whether interval lesions were missed or whether they developed rapidly since the previous colonoscopy Patients: Patients enrolled in a colonoscopic based screening programme due to a personal history of colorectal neoplasia or a significant family history. Methods: Patients within the screening programme were invited to perform an immunochemical FOBT (Inform). A positive result was followed by colonoscopy; significant neoplasia was defined as colorectal cancer, adenomas either >10 mm or with a villous component, high grade dysplasia, or multiplicity (>3 adenomas). Participation rates were determined for age, sex, and socioeconomic subgroups. Colonoscopy recall databases were examined to determine the interval between previous colonoscopy and FOBT offer, and correlations between lesion characteristics and interval time were determined. Results: A total of 785 of 1641 patients invited (47.8%) completed an Inform kit. A positive result was recorded for 57 (7.3%). Fifty two of the 57 test positive patients completed colonoscopy; 14 (1.8% of those completing the FOBT) had a significant neoplastic lesion. These consisted of six colorectal cancers and eight significant adenomas. Conclusions: A one off immunochemical faecal occult blood test within a colonoscopy based surveillance programme had a participation rate of nearly 50% and appeared to detect additional pathology, especially in patients with a past history of colonic neoplasia.

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Section: Discussionmentioning

confidence: 91%

Interval faecal occult blood testing in a colonoscopy based screening programme detects additional pathology

Bampton

2005

Gut

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“…However, small sample sizes and small numbers of target lesions hamper the generalization of these results. In patients with a personal history of CRC, one study showed a 100% sensitivity for detecting 9 recurrent CRCs [32]. These results were obtained from stools collected with digital examination and therefore not representative for at home FIT sampling.…”

Section: Discussionmentioning

confidence: 99%

Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study

et al. 2012

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BackgroundGiven the increasing burden on colonoscopy capacity, it has been suggested that faecal immunochemical test (FIT) results could guide surveillance colonoscopy intervals. Against this background, we have evaluated the test accuracy of single and double FIT sampling to detect colorectal cancer (CRC) and/or advanced adenomas in an asymptomatic colonoscopy-controlled high-risk population.MethodsCohort study of asymptomatic high-risk patients (personal history of adenomas/CRC or family history of CRC), who provided one or two FITs before elective colonoscopy. Test accuracy of FIT for detection of CRC and advanced adenomas was determined (cut-off level 50 ng/ml).Results1,041 patients provided a FIT (516 personal history of adenomas, 172 personal history of CRC and 353 family history of CRC). Five CRCs (0.5%) and 101 advanced adenomas (9.7%) were detected by colonoscopy. Single FIT sampling resulted in a sensitivity, specificity, PPV and NPV for CRC of 80%, 89%, 3% and 99.9%, respectively, and for advanced adenoma of 28%, 91%, 24% and 92%, respectively. Double FIT sampling did not result in a significantly higher sensitivity for advanced neoplasia. Simulation of multiple screening rounds indicated that sensitivity of FIT for advanced adenoma could reach 81% after 5 screening rounds.ConclusionsIn once-only FIT sampling before surveillance colonoscopy, 70% of advanced neoplasia were missed. A simulation approach indicates that multiple screening rounds may be more promising in detecting advanced neoplasia and could potentially alleviate endoscopic burden.

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“…In Studien zwischen 1997 und Februar 2008 wird über niedrige Zahlen der intraluminalen Rezidive und metachronen KRK, die in der Nachsorge-Koloskopie entdeckt werden, berichtet (1-9 %) [54,[57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] (vgl. Tab.…”

Section: Rezidive Von Lokalen Und Metachronen Karzinomen Und Von Adenunclassified

“…Die Zahl der adenomatösen Polypen, aufgezeigt in Tab. e 5, ist höher (zwischen 7 % und 34 %) [59,60,[64][65][66][67][68][69][70], besonders bei vorhandenen synchronen Polypen in der perioperativen Koloskopie [57]. Die meisten Rezidive treten innerhalb von zwei Jahren nach der Operation auf [52,[74][75][76][77][78][79] und nur wenige Rezidive (1-12 %) treten noch nach fünf Jahren auf [52,[80][81][82].…”

Section: Rezidive Von Lokalen Und Metachronen Karzinomen Und Von Adenunclassified

Der angemessene Einsatz der Koloskopie in Europa (EPAGE II)

Arditi¹,

Gonvers²,

Burnand³

et al. 2009

Endosk heute

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A novel indicator for surveillance colonoscopy following colorectal cancer resection

Cited by 22 publications

References 16 publications

Interval faecal occult blood testing in a colonoscopy based screening programme detects additional pathology

Interval faecal occult blood testing in a colonoscopy based screening programme detects additional pathology

Faecal immunochemical test accuracy in patients referred for surveillance colonoscopy: a multi-centre cohort study

Der angemessene Einsatz der Koloskopie in Europa (EPAGE II)

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