A novel insoluble film based on crosslinked-starch with gelatin containing ZnO-loaded halloysite nanotube and bacterial nanocellulose for wound healing applications

Jaberifard, Farnaz; Ghorbani, Marjan; Arsalani, Nasser; Mostafavi, Hossein

doi:10.1016/j.clay.2022.106667

Cited by 35 publications

(9 citation statements)

References 74 publications

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“…Nano- and microscale ZnO-based antibacterial agents represent viable and attractive candidates for novel applications. These include multifunctional dressings [ 37 ], nanostructured scaffolds [ 38 ], photocatalytic wearables [ 39 ], and more [ 40 ]. As such, insights into the fundamental interactions at the interface of the crystalline surface and bacteria cell wall as well as the solid–liquid interface between the free surface and the local bacterial environment are necessary to improve both the control and design of potential antibacterial agents.…”

Section: Discussionmentioning

confidence: 99%

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

et al. 2023

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Nano- and microscale zinc oxide (ZnO) exhibits significant potential as a novel antibacterial agent in biomedical applications. However, the uncertainty regarding the underlying mechanisms of the observed antimicrobial action inhibits the realization of this potential. Particularly, the nature of interactions at the free crystalline surface and the influence of the local bacterial environment remains unclear. In this investigation, we utilize ZnO particles synthesized via tunable hydrothermal growth method as a platform to elucidate the effects of interactions with phosphate-rich environments and differentiate them from those with bacteria. This is achieved using the time- and energy-dependent surface photovoltage (SPV) to monitor modifications of the surface electronic structure and surface charge dynamics of the ZnO particles due to these interactions. It is found that there exists a dramatic change in the SPV transients after exposure to phosphate-rich environments. It also presents differences in the sub-bandgap surface electronic structure after these exposures. It can be suggested that these phenomena are a consequence of phosphate adsorption at surface traps corresponding to zinc deficiency defects. This effect is shown to be suppressed in the presence of Staphylococcus aureus bacteria. Our results support the previously proposed model of the competitive nature of interactions between S. aureus and aqueous phosphates with the free surface of ZnO and bring greater clarity to the effects of phosphate-rich environments on bacterial growth inhibition of ZnO.

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Section: Discussionmentioning

confidence: 99%

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

et al. 2023

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“…The film greatly increased the proliferation of NIH-3T3 fibroblast cells. Moreover, HNTs and zinc oxide had a synergic antibacterial effect, leading to an inhibition of the growth of E. coli and S. aureus [ 64 ]. HNTs were also combined with Au nanoparticles and loaded into a chitin hydrogel.…”

Section: Natural Claysmentioning

confidence: 99%

Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields

et al. 2023

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Clay minerals are historically among the most used materials with a wide variety of applications. In pharmaceutical and biomedical fields, their healing properties have always been known and used in pelotherapy and therefore attractive for their potential. In recent decades, the research has therefore focused on the systematic investigation of these properties. This review aims to describe the most relevant and recent uses of clays in the pharmaceutical and biomedical field, especially for drug delivery and tissue engineering purposes. Clay minerals, which are biocompatible and non-toxic materials, can act as carriers for active ingredients while controlling their release and increasing their bioavailability. Moreover, the combination of clays and polymers is useful as it can improve the mechanical and thermal properties of polymers, as well as induce cell adhesion and proliferation. Different types of clays, both of natural (such as montmorillonite and halloysite) and synthetic origin (layered double hydroxides and zeolites), were considered in order to compare them and to assess their advantages and different uses.

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“…Jaberifard's research involved the treatment of HNTs with alkali and subsequent modification with ZnO nanoparticles (ZnONPs). [ 141 ] This modified HNT was then crosslinked with dialdehyde starch‐gelatin and bacterial cellulose to create a film product. The resulting film, which contained 5 wt% ZHNTs, displayed desirable attributes such as high thermal stability, enhanced cell adhesion, effective antibacterial properties, and favorable cell proliferation rates.…”

Section: Halloysite Nanotubes In Wound Healingmentioning

confidence: 99%

Recent Advances of Halloysite Nanotubes in Biomedical Applications

Jiang,

Sun,

Liu

et al. 2023

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Halloysite nanotubes (HNTs) have emerged as a highly regarded choice in biomedical research due to their exceptional attributes, including superior loading capacity, customizable surface characteristics, and excellent biocompatibility. HNTs feature tubular structures comprising alumina and silica layers, endowing them with a large surface area and versatile surface chemistries that facilitate selective modifications. Moreover, their substantial pore volume and wide range of pore sizes enable efficient entrapment of diverse functional molecules. This comprehensive review highlights the broad biomedical application spectrum of HNTs, shedding light on their potential as innovative and effective therapeutic agents across various diseases. It emphasizes the necessity of optimizing drug delivery techniques, developing targeted delivery systems, rigorously evaluating biocompatibility and safety through preclinical and clinical investigations, exploring combination therapies, and advancing scientific understanding. With further advancements, HNTs hold the promise to revolutionize the pharmaceutical industry, opening new avenues for the development of transformative treatments.

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A novel insoluble film based on crosslinked-starch with gelatin containing ZnO-loaded halloysite nanotube and bacterial nanocellulose for wound healing applications

Cited by 35 publications

References 74 publications

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

Surface Photovoltage Response of ZnO to Phosphate-Buffered Saline Solution with and without Presence of Staphylococcus aureus

Natural and Synthetic Clay Minerals in the Pharmaceutical and Biomedical Fields

Recent Advances of Halloysite Nanotubes in Biomedical Applications

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