A novel interface between the N-terminal and coiled-coil domain of STAT1 functions in an auto-inhibitory manner
Linus Remling,
Anke Gregus,
Oliver Wirths
et al.
Abstract:Background
STAT1 is an intracellular signaling molecule that is crucially involved in the regulation of the innate immune system by activation of defense mechanisms against microbial pathogens. Phosphorylation-dependent activation of the STAT1 transcription factor is associated with a conversion from an antiparallel to parallel dimer configuration, which after nuclear import binds to DNA. However, not much is known about the specific intermolecular interactions that stabilize unphosphorylated, … Show more
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