A novel intracochlear injection method for rapid drug delivery to vestibular end organs

Raghu, Vishal; Ramakrishna, Yugandhar; Burkard, Robert; Sadeghi, Soroush G.

doi:10.1016/j.jneumeth.2020.108689

Cited by 4 publications

(2 citation statements)

References 44 publications

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“…The advantages of this method consist of the local delivery of the substance and direct access to the perilymph of the inner ear. Although this delivery site is not as extensively used in preclinical studies compared to the previously described sites, the local delivery of different substances at this level of the inner ear remains a viable option [33,34].…”

Section: Intracochlearmentioning

confidence: 99%

Recent Advances and Future Research Directions for Hearing Loss Treatment Based on Nanoparticles

Dindelegan

Blebea

Perde-Schrepler

et al. 2022

Journal of Nanomaterials

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Sensorineural hearing loss is a prevailing health issue worldwide which usually occurs due to sensory inner ear cell destruction. These cells, once damaged, do not regenerate in mammals resulting in permanent hearing loss. Effective treatment of inner ear diseases is strongly correlated with efficient drug delivery to the inner ear. Researchers have made important efforts to deliver drugs locally to the inner ear in a safe and controllable manner. Different strategies and drug delivery systems were used to mitigate the resistance exerted by the multiple anatomical barriers found in the inner ear. Nanoparticles represent an option for sustained drug delivery to the inner ear. Nanocarrier-based systems can diffuse through the round and oval window membrane allowing for direct delivery into the inner ear components. Certain types of enhanced nanoparticles can focus on specific parts of the inner ear, providing targeted delivery which might represent the future therapy for sensorineural hearing loss. In this article, we will present the latest advances in the treatment of hearing loss based on nanoparticles.

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Section: Intracochlearmentioning

confidence: 99%

Recent Advances and Future Research Directions for Hearing Loss Treatment Based on Nanoparticles

Dindelegan

Blebea

Perde-Schrepler

et al. 2022

Journal of Nanomaterials

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“…Active, acute, local delivery has been done with micropipettes or syringe pumps to investigate various drug delivery features such as concentration gradients of a delivered drug from base to apex in the cochlea [15][16][17][18], or to deliver gene and stem cell therapies to the inner ear [19]. Commercially available osmotic pumps (Durect Corp, Cupertino, CA) have also been used extensively for more sustained delivery profiles [20][21][22].…”

Section: Micropumps For Inner Ear Drug Deliverymentioning

confidence: 99%

Microtechnologies for inner ear drug delivery

Forouzandeh

Borkholder²

2020

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review-Treatment of auditory dysfunction is dependent on inner ear drug delivery, with microtechnologies playing an increasingly important role in cochlear access and pharmacokinetic profile control. This review examines recent developments in the field relevant to both clinical and animal research environments.Recent findings-Micropump technologies are being developed that provide dynamic control of flow rates with refillable reservoirs to enable timed delivery of a series of multiple agents for protection or regeneration therapies. These micropumps can be combined with cochlear implants with integral catheters or used independently with cochleostomy or RWM delivery modalities for therapy development in animal models. Sustained release of steroids with coated cochlear implants remains an active area of research with first-time-in-human demonstration of reduced electrode impedances. Advanced coatings containing neurotrophin producing cells have enhanced spiral ganglion neuron survival in animal models, and have proven safe in a human study. Microneedles have emerged as a novel method for controlled microperforation of the round window membrane with significant enhancement in permeability, which can be combined with emerging matrix formulations that optimize biological interaction and drug release kinetics.Summary-Microsystem technologies and associated fabrication techniques are providing enhanced and more controlled access to the inner ear for advanced drug delivery approaches, alone and in conjunction with cochlear implants.

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Performance comparison of two motion modes of a piezoelectric inertial linear motor and its potential application in cell manipulation

et al. 2021

Mechanical Systems and Signal Processing

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A novel intracochlear injection method for rapid drug delivery to vestibular end organs

Cited by 4 publications

References 44 publications

Recent Advances and Future Research Directions for Hearing Loss Treatment Based on Nanoparticles

Recent Advances and Future Research Directions for Hearing Loss Treatment Based on Nanoparticles

Microtechnologies for inner ear drug delivery

Performance comparison of two motion modes of a piezoelectric inertial linear motor and its potential application in cell manipulation

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