A novel inverse optimization based three‐dimensional conformal radiotherapy technique in craniospinal irradiation

Biltekin, Fatih; Yazıcı, Gözde; Özyiğit, Gökhan

doi:10.1007/s13246-021-00976-6

Cited by 1 publication

(1 citation statement)

References 43 publications

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“…Although effective in controlling the disease, 3DCRT does not spare any organs and causes significant acute and late morbidities depending on the dose delivered. In an attempt to maintain tumor control, improve dose conformity, and decrease dose to organs at risk (OAR), intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) have been used in clinical practice for CSI [ 2 , 3 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure

Silveira

Pavoni

Bruno

et al. 2022

Gels

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Craniospinal irradiation (CSI) is a complex radiation technique employed to treat patients with primitive neuroectodermal tumors such as medulloblastoma or germinative brain tumors with the risk of leptomeningeal spread. In adults, this technique poses a technically challenging planning process because of the complex shape and length of the target volume. Thus, it requires multiple fields and different isocenters to guarantee the primary-tumor dose delivery. Recently, some authors have proposed the use IMRT technique for this planning with the possibility of overlapping adjacent fields. The high-dose delivery complexity demands three-dimensional dosimetry (3DD) to verify this irradiation procedure and motivated this study. We used an optical CT and a radiochromic Fricke-xylenol-orange gel with the addition of formaldehyde (FXO-f) to evaluate the doses delivered at the field junction region of this treatment. We found 96.91% as the mean passing rate using the gamma analysis with 3%/2 mm criteria at the junction region. However, the concentration of fail points in a determined region called attention to this evaluation, indicating the advantages of employing a 3DD technique in complex dose-distribution verifications.

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