A novel label-free multi-throughput optical biosensor based on localized surface plasmon resonance

Huang, Haowen; He, Chaocai; Zeng, Yanwei; Xia, Xiaodong; Yu, Xianyong; Yi, Pinggui; Chen, Zhong

doi:10.1016/j.bios.2008.10.013

Cited by 63 publications

(38 citation statements)

References 20 publications

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“…It was found that in the course of the formation of core-shell structure, both the thickness of the shell and size of the core can be readily controlled, allowing one to tune the peak of plasmon resonant absorption red-shifted over several hundred nanometers in the visible or NIR region, a wavelength region of extreme technological interest for optical applications. Furthermore, their LSPR characteristic was similar to our previous works [27,28]. Possibly, they are suited not only for fundamental studies but also the fabrication of novel nano-biosensors.…”

Section: Introductionsupporting

confidence: 61%

A Localized Surface Plasmon Resonance Biosensor Based on Integrated Controllable Au2S/AuAgS-Coated Gold Nanorods Composite

et al. 2010

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In this work, we have demonstrated that the exquisite optical properties based on localized surface plasmon resonance (LSPR) of Au 2 S/AuAgS-coated gold nanorods (Au 2 S/AuAgS-coated GNRs) can be utilized to develop a simple and sensitive biosensor, and goat antihuman IgG can be detected by the human IgG probe as low as 0.2 nM. Moreover, we introduce an integrated LSPR biosensor constructed by integrating Au 2 S/AuAgS-coated GNRs immobilized on glass slide and isolated Au 2 S/ AuAgS-coated GNRs in the form of liquid. The detection of target binding was performed via direct spectral changes induced by changes of refractive index in the vicinity of individual particles. The integrated LSPR optical biosensor is label-free, cost-effective, and easy to fabricate and requires only a visible/near-infrared spectrometer for detection purposes. Additionally, the investigation on the mutual influence of the two types of nanorods in the integrated LSPR biosensor was performed. The results of separate experiments indicate that the nanorods in the form of isolate or in integrated exhibit a similar behavior.

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Section: Introductionsupporting

confidence: 61%

A Localized Surface Plasmon Resonance Biosensor Based on Integrated Controllable Au2S/AuAgS-Coated Gold Nanorods Composite

et al. 2010

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“…Among these geometries, nanorod is particularly interesting to us, because it provides an excellent platform with well-defined absorption spectrum for a labelfree bioanalytical assay [13][14][15][16][17][18]. The optical transduction by Au nanorods (GNRs) is based upon the phenomenon of localized surface plasmon resonance, that is, nanoSPR (or LSPR) [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Gold Nanoparticles with Plasmon Absorbance Wavelength Tunable from Visible to Near Infrared Region

et al. 2012

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Gold nanorods with localized surface plasmon resonance (LSPR) can be chemically synthesized. We systematically investigated the effects of reaction parameters and centrifugation on the fine tuning of the rod dimension in scale-up production (80-100 mL). Nanorods of absorption bands from 600-1050 nm were fabricated with precise control of the aspect ratio (AR) from 1.5 to 8.9. Although all chemicals are important in directing the nanostructure, silver ion concentration and seed/Au 3+ ratio were the most effective variations to adjust the absorption wavelength. With a single surfactant under the influence of silver nitrate, short nanorods up to AR of 5 were synthesized with corresponding maximum absorption wavelength at 902 nm. To achieve higher aspect ratio with absorption band beyond 1,000 nm, two-surfactant growth solution was sought to further elongate the rod length. Centrifugation speed and times were found to exert significant influences on the final rod dimension, which is important during the purification process. In a relatively large quantity nanorod synthesis, even distribution and sufficient mixing of chemical ingredients play an essential role in determining the yield, uniformity, and stability of the final nanorod formation.

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“…As discussed in our previous work (Huang et al, 2009), nanoparticles used in the form of a liquid solution, regardless of their shape and size, the disturbing signals from the changes of nanoparticle concentrations are hard to be avoided. When multiple washing steps are incorporated to remove unbound analytes, uncertain disturbance may occur due to the uncontrollable loss of the nanoparticles, which reduces the accuracy of biospecific measurements.…”

Section: Detection Of Biological Targets Using Immobilized Au 2 S-coamentioning

confidence: 99%

Label-free optical biosensors based on Au2S-coated gold nanorods

Huang

Liu

et al. 2009

Biosensors and Bioelectronics

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A novel label-free multi-throughput optical biosensor based on localized surface plasmon resonance

Cited by 63 publications

References 20 publications

A Localized Surface Plasmon Resonance Biosensor Based on Integrated Controllable Au2S/AuAgS-Coated Gold Nanorods Composite

A Localized Surface Plasmon Resonance Biosensor Based on Integrated Controllable Au2S/AuAgS-Coated Gold Nanorods Composite

Synthesis and Characterization of Gold Nanoparticles with Plasmon Absorbance Wavelength Tunable from Visible to Near Infrared Region

Label-free optical biosensors based on Au2S-coated gold nanorods

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