A novel LINC00478 serves as a tumor suppressor in endometrial carcinoma progression

Feng, Yingyi; Dong, Yongshun; Rao, Boqi; Yu, Yonghui; Su, Wenpeng; Zeng, Jie; Zhao, Eryong; Chen, Yongxiu; Fang, Shenying; Zhou, Yifeng; Lu, Jiachun; Qiu, Fuman

doi:10.1007/s00432-023-05282-0

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…Polypyrimidine tract binding protein 1 (PTBP1) has a negative impact on prognosis of EC by promoting the formation of pseudopodia, which are engaged in the invasion and occurrence of metastasis. Linc00478 inhibits EC progression by downregulating PTBP1 expression [ 87 ]. The last linc to mention here is linc01589.…”

Section: The Role Of Lncrna In Endometrial Cancermentioning

confidence: 99%

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Jasielski,

Zawlik,

Bogaczyk

et al. 2024

Cancers

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Endometrial cancer is one of the most common malignant tumours in women. The development of this tumour is associated with several genetic disorders, many of which are still unknown. One type of RNA molecules currently being intensively studied in many types of cancer are long non-coding RNAs (lncRNAs). LncRNA-coding genes occupy a large fraction of the human genome. LncRNAs regulate many aspects of cell development, metabolism, and other physiological processes. Diverse types of lncRNA can function as a tumour suppressor or an oncogene that can alter migration, invasion, cell proliferation, apoptosis, and immune system response. Recent studies suggest that selected lncRNAs are important in an endometrial cancer course. Our article describes over 70 lncRNAs involved in the development of endometrial cancer, which were studied via in vivo and in vitro research. It was proved that lncRNAs could both promote and inhibit the development of endometrial cancer. In the future, lncRNAs may become an important therapeutic target. The aim of this study is to review the role of lncRNAs in the development of carcinoma of uterine body.

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Section: The Role Of Lncrna In Endometrial Cancermentioning

confidence: 99%

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Jasielski,

Zawlik,

Bogaczyk

et al. 2024

Cancers

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MIR99AHG: a novel lncRNA host gene with diverse regulatory roles in cancer

Si,

Su,

et al. 2024

CCB

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MIR99AHG, a recently discovered long non-coding RNA (lncRNA), serves as the host gene for the miR-99a/let-7c/miR-125b-2 miRNA cluster. The intricate processing of its three introns yields three distinct micro RNAs (miRNAs). Experimental evidence highlights significant variations in MIR99AHG expression across various cancer types, indicating its potential as a diagnostic marker for cancer. Moreover, FOXA1 acts as an upstream regulator, actively promoting MIR99AHG expression. MIR99AHG, in turn, regulates five downstream proteins (ANXA2, PTBP1, MMP9, PBX3, and PHB2), as well as three competing endogenous RNA (ceRNA) axes and three signaling pathways. This broad spectrum of regulatory effects underscores the pivotal role of MIR99AHG in shaping the behavior of cancer cells. In cancer treatment, MIR99AHG's functions are equally noteworthy. Experimental findings suggest its impact on immune cell activity within the tumor micro-environment and its role in modulating cancer cell resistance to chemotherapeutic drugs. Follow-up studies on patients further confirm the close association between high MIR99AHG expression and poor prognosis across various cancers, exhibiting significant statistical correlations with various pathological behaviors. In summary, MIR99AHG, acting as a multifaceted lncRNA, not only introduces a potential novel marker for cancer diagnosis but also demonstrates significant application value in cancer treatment and prognosis evaluation.

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ZFHX2-AS1 interacts with DKC1 to regulate ARHGAP5 pseudouridylation and suppress ovarian cancer progression

Dong,

Zhang,

Huang

et al. 2024

Cellular Signalling

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A novel LINC00478 serves as a tumor suppressor in endometrial carcinoma progression

Cited by 3 publications

References 41 publications

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

MIR99AHG: a novel lncRNA host gene with diverse regulatory roles in cancer

ZFHX2-AS1 interacts with DKC1 to regulate ARHGAP5 pseudouridylation and suppress ovarian cancer progression

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