2022
DOI: 10.3389/fnins.2022.1040182
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A novel link between silent information regulator 1 and autophagy in cerebral ischemia-reperfusion

Abstract: Cerebral ischemia is one of the leading causes of death and disability worldwide. Although revascularization via reperfusion combined with advanced anticoagulant therapy is currently a gold standard treatment for patients, the reperfusion itself also results in a serious dysfunction termed cerebral ischemia-reperfusion (I/R) injury. Silent information regulator 1 (sirtuin 1, SIRT1), is a classic NAD+-dependent deacetylase, which has been proposed as an important mediator in the alleviation of cerebral ischemia… Show more

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Cited by 7 publications
(4 citation statements)
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“…The acquired results add to this knowledge by suggesting that miR-10a is another miRNA that is dysregulated in SCI and may contribute to its pathogenesis. Interestingly, it was observed that miR-10a directly targets SIRT1, a sirtuin family member of NAD+dependent protein deacetylases, which modulates cellular processes, including apoptosis, in ammation, and senescence (16,18,19). SCI rats indicated reduced SIRT1 expression, whereas miR-10a downregulation increased its expression, consistent with literature that miRNAs modulate SIRT1 expression.…”
Section: Discussionsupporting
confidence: 81%
See 1 more Smart Citation
“…The acquired results add to this knowledge by suggesting that miR-10a is another miRNA that is dysregulated in SCI and may contribute to its pathogenesis. Interestingly, it was observed that miR-10a directly targets SIRT1, a sirtuin family member of NAD+dependent protein deacetylases, which modulates cellular processes, including apoptosis, in ammation, and senescence (16,18,19). SCI rats indicated reduced SIRT1 expression, whereas miR-10a downregulation increased its expression, consistent with literature that miRNAs modulate SIRT1 expression.…”
Section: Discussionsupporting
confidence: 81%
“…SIRT1 has neuroprotective activity against various neurological disorders, such as SCI (17). It regulates various cellular processes, including in ammation, apoptosis, and oxidative stress, through its deacetylase activity and interaction with various transcription factors and coregulators (18,19). In this investigation, the potential interaction sites between SIRT1 and miR-10a were elucidated via bioinformatics analysis.…”
Section: Introductionmentioning
confidence: 92%
“…After FOXO3a activity is inhibited, the ovarian primordial follicular reserve is reduced, and the inhibition of mTOR activity promotes follicular dormancy [14]. FOXO activates the expression of the antioxidant genes SOD2 and CAT, enhancing cellular resistance to ROS-induced oxidative stress [15]. Cyclic adenosine monophosphate-dependent protein kinase A (KAPCA) is a catalytic subunit of protein kinase A (PKA).…”
Section: Discussionmentioning
confidence: 99%
“…Recently, autophagy has been recognized as a critical process in ischemic stroke in addition to neurodegenerative diseases ( Yang Z. et al, 2022 ). And growing evidence suggests that Sirt1 may promote neuronal cell survival and alleviate cerebral I/R injury by modulating autophagy process ( Tang et al, 2022 ; Teertam and Phanithi, 2022 ).…”
Section: Potential Mechanisms Of Sirt1 For Ischemic Strokementioning
confidence: 99%