A novel local thermal non-equilibrium model for biological tissue applied to multiple-antennas configurations for thermal ablation

Andreozzi, Assunta; Brunese, Luca; Iasiello, Marcello; Tucci, Claudio; Vanoli, Giuseppe Peter

doi:10.1080/10407782.2020.1835083

Cited by 19 publications

(7 citation statements)

References 30 publications

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“…In fact, the distance ad can be increased to increase the coverage region; therefore, the input power could also be increased. Unfortunately, most of the literature reports the evaluation of using antenna array configurations to treat soft tissues [ 20 , 21 , 22 , 29 ], making it impossible to compare our results in more detail. As it is reported in the literature, electromagnetic models are maturing rapidly; however, the accuracy of thermal models is still under development.…”

Section: Discussionmentioning

confidence: 99%

Thermal Evaluation of Multi-Antenna Systems Proposed to Treat Bone Tumors: Finite Element Analysis

Trujillo-Romero

Merida²,

Ramírez-Guzmán³

et al. 2022

Sensors

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Microwave ablation is commonly used in soft tissue tumors, but its application in bone tumors has been barely analyzed. Antennas to treat bone tissue (~3 cm2), has been lately designed. Bone tumors at pathological stage T1 can reach 8 cm wide. An antenna cannot cover it; therefore, our goal is to evaluate the thermal performance of multi-antenna arrays. Linear, triangular, and square configurations of double slot (DS) and monopole (MTM) antennas were evaluated. A parametric study (finite element method), with variations in distance between antennas (ad) and bone thickness (bt) was implemented. Array feasibility was evaluated by SWR, ablated tissue volume, etc. The linear configuration with DS and MTM antennas showed SWR ≤ 1.6 for ad = 1 mm–15 mm and bt = 20 mm–40 mm, and ad = 10 mm–15 mm and bt = 25 mm–40 mm, respectively; the triangular showed SWR ≤ 1.5 for ad = 5 mm–15 mm and bt = 20 mm–40 mm and ad = 10 mm–15 mm and bt = 25 mm–40 mm. The square configuration (DS) generated SWR ≤ 1.5 for ad = 5 mm–20 mm and bt = 20 mm–40 mm, and the MTM, SWR ≤ 1.5 with ad = 10 mm and bt = 25 mm–40 mm. Ablated tissue was 4.65 cm3–10.46 cm3 after 5 min. According to treatment time and array configuration, maximum temperature and ablated tissue is modified. Bone tumors >3 cm3 can be treated by these antenna-arrays.

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Section: Discussionmentioning

confidence: 99%

Thermal Evaluation of Multi-Antenna Systems Proposed to Treat Bone Tumors: Finite Element Analysis

Trujillo-Romero

Merida²,

Ramírez-Guzmán³

et al. 2022

Sensors

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“…The first one is the tissue phase, which includes cells and interstitial spaces, and the second one is the blood phase, represented by the blood vessels that permeate in the tissue. Moreover, a local thermal nonequilibrium model is implemented and modified to include the vaporization of the two distinct phases water contents separately, as in [23]. Therefore, two different equations can be written for the two phases as follows.…”

Section: Methodsmentioning

confidence: 99%

“…The authors concluded that the required uniform heating can be achieved even without gold nanoshells or other invasive procedures for some superficial tumors. Finally, Andreozzi et al [23] developed a novel local thermal nonequilibrium model for biological tissue applied to multiple-antenna configurations for thermal ablation, using a porous media-based model modified in order to include water vaporization in tissue and blood separately based on their different water content.…”

Section: Introductionmentioning

confidence: 99%

Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity

et al. 2021

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Thermal ablation is a minimally or noninvasive cancer therapy technique that involves fewer complications, shorter hospital stays, and fewer costs. In this paper, a thermal-ablation bioheat model for cancer treatment is numerically investigated, using a porous media-based model. The main objective is to evaluate the effects of a variable blood volume fraction in the tumoral tissue (i.e., the porosity), in order to develop a more realistic model. A modified local thermal nonequilibrium model (LTNE) is implemented including the water content vaporization in the two phases separately and introducing the variable porosity in the domain, described by a quadratic function changing from the core to the rim of the tumoral sphere. The equations are numerically solved employing the finite-element commercial code COMSOL Multiphysics. Results are compared with the results obtained employing two uniform porosity values (ε = 0.07 and ε = 0.23) in terms of coagulation zones at the end of the heating period, maximum temperatures reached in the domain, and temperature fields and they are presented for different blood vessels. The outcomes highlight how important is to predict coagulation zones achieved in thermal ablation accurately. In this way, indeed, incomplete ablation, tumor recurrence, or healthy tissue necrosis can be avoided, and medical protocols and devices can be improved.

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“…among the results obtained [12,13]. One of the most promising models is the porous mediabased [14] local thermal non equilibrium (LTNE), formerly developed by Xuan and Roetzel [15] and then modified several times throughout the years [16][17][18][19][20][21][22] to consider different tissue properties, vascular structures, and biomedical applications [23][24][25][26]. A common limit to all these models is that they neglect the variation in blood volume fraction (namely the porosity variation) inside the tumor, and between the tumor and the surrounding healthy tissue.…”

Section: Introductionmentioning

confidence: 98%

Mathematical modeling of microwave liver ablation with a variable-porosity medium approach

Tucci

Trujillo

Berjano

et al. 2022

Computer Methods and Programs in Biomedicine

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A novel local thermal non-equilibrium model for biological tissue applied to multiple-antennas configurations for thermal ablation

Cited by 19 publications

References 30 publications

Thermal Evaluation of Multi-Antenna Systems Proposed to Treat Bone Tumors: Finite Element Analysis

Thermal Evaluation of Multi-Antenna Systems Proposed to Treat Bone Tumors: Finite Element Analysis

Numerical Investigation of a Thermal Ablation Porous Media-Based Model for Tumoral Tissue with Variable Porosity

Mathematical modeling of microwave liver ablation with a variable-porosity medium approach

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