Aiming at the specific mission requirements of high-voltage transmission line inspection, a modeling method based on columnar space is proposed, which simplifies the complexity of traditional methods to a certain extent, and ensures enough modeling accuracy. Then, an improved random chemical reaction algorithm based on dual container strategy (RMCRO) is proposed, and the new algorithm divides the set of molecules into two subsets and puts them into two reaction containers, respectively. A subset introducing PSO algorithm strategy strengthens the strategy of diversity algorithm molecules and enhances the global search capability of the algorithm. Additionally, another subset introducing elitist selection and differential strategy strengthens the local search ability of the algorithm and accelerates the convergence speed. Then, through the exchange of the two subsets under certain conditions, the advantages of the two subsets can be further integrated to eliminate the original defects. Finally, respectively analyze the simulation of two typical scenarios of transmission line inspection based on multi-rotor UAV, the simulation results show that the proposed algorithm can avoid the local minimum, the path planning is shorter, and it can make the airborne camera equipment working in a more stable state. KEYWORDS chemical reaction algorithm, path planning, UAV 1 INTRODUCTION Electricity plays a more and more important role in various areas of our social life. The key problem in power system management is to ensure the stability of the power equipment and the safe operation of the electric power system. 1 Because of long-term exposure to the external environment, transmission line towers and insulator strings are affected by human factors, bad weather, mechanical tension and electrical flashover, material aging, and other reasons. Moreover, they all may cause the line breaking and cracking, corrosion, and other damage. If timely maintenancesare not carried out, it will affect strictly normal operation of heavy power, and even cause blackout serious accidents and safety hazards. 2 Therefore, in order to ensure the safe operation of transmission lines, it is necessary to conduct regular inspections of transmission lines, understand the operation status of transmission lines, and eliminate potential dangers, which is very important for ensuring the safe and normal operation of transmission lines. [3][4][5] Conventional inspection of transmission lines is the most important and effective measure to ensure the safe operation of the power grid. Due to the current high-voltage transmission lines that generally pass through mountains and lakes, the traditional manual inspection mode not only has a large amount of work but also cannot effectively protect the life of patrol personnel. Moreover, the transmission lines are all located in the field, and there are many "blind areas" for patrol inspection. 6,7 In recent years, the transmission line inspection mode based on UAV has come into being. In addition, the transmission line in...