In this article, a new design of circular cladding with a rotated-hexacore in photonic crystal fiber (RH-CPCF) has been suggested for chemical sensing application in the THz regime. The five layers circular cladding and two layers rotatedhexacore in circular shape are designed here. All numerical results are obtained with a procedure of finite element method and perfectly match layered boundary condition in terahertz (THz) wave propagation. After the simulation result, the proposed RH-CPCF shows the high relative sensitivity is 76.44%, 77.16% and 73.20% for three chemicals such as Ethanol (n = 1.354), Benzene (n = 1.366) and Water (n = 1.330) at 1 THz. On the other hand, the low confinement losses are 2.33 × 10 −03 dB/m, 3.07 × 10 −06 dB/m and 2.84 × 10 −02 dB/m for same in three chemicals at 1 THz. Moreover, effective area, effective mode index and total power fraction in core air holes are also briefly described here. In addition, this proposed circular photonic crystal fiber (RH-CPCF) can be used especially for chemical sensing in biomedical, industrial quality control, material research, micro-optics and many communication applications in THz technology.