A novel luminescence-functionalized metal-organic framework nanoflowers electrochemiluminesence sensor via “on-off” system

Shu, Zhu; Xia, Lin; Ran, Peiyao; Xia, Qiao; Yang, Chengcheng; Ma, Jiao; Fu, Yingzi

doi:10.1016/j.bios.2016.12.069

Cited by 47 publications

(30 citation statements)

References 28 publications

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“…Nowadays, some scientists had turned their attention to the ECL molecules functionalized MOFs and to design various ECL biosensors. Although, most literature just utilized the high loading capacity of MOFs to physically encapsulate ECL molecules, ,,, a few works directly use ECL luminophore as organic ligand to synthesize Ru-MOFs. − Moreover, compared to the bulk MOF crystals, two-dimensional (2D) MOF nanosheets expose more accessible active sites on the large surface and promote the contact with substrate molecules, which furthers the sensing performance of MOFs. ,− 2D MOF nanosheets can be directly obtained by using the structure-directing effect of PVP without a postsynthetic exfoliation process . For the synthesis of MOFs, the ligands always possess some specific functional groups (−NH 2 , −COOH, etc.).…”

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confidence: 99%

Ultrasensitive Immunosensor for Cardiac Troponin I Detection Based on the Electrochemiluminescence of 2D Ru-MOF Nanosheets

et al. 2019

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Electrochemiluminescence (ECL)-functionalized metal–organic frameworks (MOFs) have attracted increasing attention in biosensing in virtue of their diverse and tunable optical properties. A famous ECL luminophore, carboxyl-rich tris(4,4′-dicarboxylic acid-2,2′-bipyridyl) ruthenium(II) (Ru(dcbpy)3 2+), possesses the characteristics of good water solubility and excellent ECL performance and also has the potential to be the organic ligand of metal–organic frameworks. Herein, functionalized MOF nanosheets (RuMOFNSs) containing plenty of Ru(dcbpy)3 2+ in the frameworks were synthesized in aqueous solution by a simple one-pot method. In this protocol, Ru(dcbpy)3 2+ acted as organic ligand to coordinate with Zn2+ originated from Zn(NO3)2, and polyvinylpyrrolidone (PVP) was used as structure-directing agent to control the formation of sheetlike structure. For practical application, a “signal-on” ECL immunosensor was designed for cardiac troponin I (cTnI) detection by employing RuMOFNSs as ECL probe. The immunosensor exhibited high sensitivity and excellent selectivity for cTnI detection in the range from 1 fg/mL to 10 ng/mL with a detection limit as low as 0.48 fg/mL. Finally, the biosensor was successfully applied for the detection of cTnI in human serum sample with satisfactory results, demonstrating its potential application in bioanalysis and clinical diagnosis.

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confidence: 99%

Ultrasensitive Immunosensor for Cardiac Troponin I Detection Based on the Electrochemiluminescence of 2D Ru-MOF Nanosheets

et al. 2019

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“…The electrode modification and the ECL mechanism were monitored through EIS. From the Nyquist plots in Figure 5 , a typical semicircle, which is equal to the electron-transfer resistance [ 30 , 31 ], was observed for all modified GCEs. The semicircle diameters of the bare GCE, nafion/GCE, Fe 3 O 4 -NCs/GCE and nafion/Fe 3 O 4 -NCs/GCE were about 150, 130, 140 and 123 Ω, respectively.…”

Section: Resultsmentioning

confidence: 99%

An Electrochemiluminescence Sensor Based on Nafion/Magnetic Fe3O4 Nanocrystals Modified Electrode for the Determination of Bisphenol A in Environmental Water Samples

Chai

Zhao

et al. 2018

Sensors

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The well-dispersive and superparamagnetic Fe3O4-nanocrystals (Fe3O4-NCs) which could significantly enhance the anodic electrochemiluminescence (ECL) behavior of luminol, were synthesized in this study. Compared to ZnS, ZnSe, CdS and CdTe nanoparticles, the strongest anodic ECL signals were obtained at +1.6 V on the Fe3O4-NCs coated glassy carbon electrode. The ECL spectra revealed that the strong ECL resonance energy transfer occurred between luminol and Fe3O4-NCs. Furthermore, under the optimized ECL experimental conditions, such as the amount of Fe3O4-NCs, the concentration of luminol and the pH of supporting electrolyte, BPA exhibited a stronger distinct ECL quenching effect than its structural analogs and a highly selective and sensitive ECL sensor for the determination of bisphenol A (BPA) was developed based on the Fe3O4-NCs. A good linear relationship was found between the ECL intensity and the increased BPA concentration within 0.01–5.0 mg/L, with a correlation coefficient of 0.9972. The detection limit was 0.66 × 10−3 mg/L. Good recoveries between 96.0% and 105.0% with a relative standard deviation of less than 4.8% were obtained in real water samples. The proposed ECL sensor can be successfully employed to BPA detection in environmental aqueous samples.

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“…For example, doping fullerenes in MOFs increases conductivity to build ECL sensors to detect tryptophan. 56 One-step calcination was used to combine Ni and NiO nanoparticles and C frame with Ni-MOF to form a Ni-MOF/Ni/NiO/carbon frame nanocomposite to improve its conductivity and construct a non-enzymatic glucose sensor. 57 The above cases show that the application of MOFs with improved conductivity in biosensors is tempting.…”

Section: Application In Bionsensorsmentioning

confidence: 99%

Research Progress on Improvement of Conductivity of MOFs and Their Application in Bionsensors: A Review

et al. 2021

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Metal organic framework materials (MOFs) have a drawback that limits their wider application: poor electrical conductivity. In this paper, some research advances in improving the conductivity of MOFs in recent years are reviewed. They are divided into two categories: intrinsic improvement of conductivity and extrinsic improvement of conductivity. The application of MOFs with improved electrical conductivity in the construction of biosensors is shown. Finally, research trends of improving the conductivity of MOFs and their applications in biosensors are summarized, and promising directions such as the comprehensive application of multiple strategies and the spaceoriented assembly of MOFs are proposed.

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A novel luminescence-functionalized metal-organic framework nanoflowers electrochemiluminesence sensor via “on-off” system

Cited by 47 publications

References 28 publications

Ultrasensitive Immunosensor for Cardiac Troponin I Detection Based on the Electrochemiluminescence of 2D Ru-MOF Nanosheets

Ultrasensitive Immunosensor for Cardiac Troponin I Detection Based on the Electrochemiluminescence of 2D Ru-MOF Nanosheets

An Electrochemiluminescence Sensor Based on Nafion/Magnetic Fe3O4 Nanocrystals Modified Electrode for the Determination of Bisphenol A in Environmental Water Samples

Research Progress on Improvement of Conductivity of MOFs and Their Application in Bionsensors: A Review

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