2024
DOI: 10.1021/acschembio.4c00092
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A Novel Lysosome Targeting Chimera for Targeted Protein Degradation via Split-and-Mix Strategy

Jinpeng Wang,
Yuechen Wang,
Fenfang Yang
et al.

Abstract: Targeted protein degradation is becoming more and more important in the field of drug development. Compared with proteasomal-based degraders, lysosomal-based degraders have a broader target spectrum of targets, which have been demonstrated to have great potential, especially in degrading undruggable proteins. Recently, we developed a programmable and facile screening PROTAC development platform based on peptide selfassembly termed split-and-mix PROTAC (SM-PROTAC). In this study, we applied this technology for … Show more

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