A novel marker of systemic inflammation in psoriasis and related comorbidities:  chitotriosidase

Ilanbey, Bilal; Elmas, Ömer Faruk; Sözmen, Eser Yıldırım; Günay, Ümran; Demirbaş, Abdullah; Atasoy, Mustafa; Türsen, Ümit; Lotti, Torello

doi:10.3906/sag-2101-137

Cited by 4 publications

(1 citation statement)

References 22 publications

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“…One article found chitotriosidase to be a marker of systemic inflammation in psoriasis, but associations between chitotriosidase and cutaneous sarcoidosis have not been reported. 8 Because skin lesions are the manifesting symptoms in 20% of patients with sarcoidosis, chitotriosidase is a marker that dermatologists should use in the diagnostic work-up for cutaneous sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Chitotriosidase: Providing confirmation of cutaneous sarcoidosis when angiotensin converting enzyme fails

Reeves,

Powers,

Brodell

2024

JAAD Case Reports

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Section: Discussionmentioning

confidence: 99%

Chitotriosidase: Providing confirmation of cutaneous sarcoidosis when angiotensin converting enzyme fails

Reeves,

Powers,

Brodell

2024

JAAD Case Reports

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Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia

Canbay,

Canda,

Yazıcı

et al. 2024

Lipids Health Dis

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Aim Elevated levels of cholesterol in the bloodstream, also referred to as hypercholesterolemia, pose a significant risk for the onset of cardiovascular and cerebrovascular diseases. Oxysterols, cholesterol-derived oxidized compounds that form enzymatically or non-enzymatically, contribute to the development of atherosclerosis and coronary artery disease. This study aimed to examine the critical oxysterol levels in children and adolescents with hypercholesterolemia and explore the correlation between these levels, oxidative stress, and atherosclerosis progression. Materials and methods The study included 20 patients with familial hypercholesterolemia (FH) and 20 healthy individuals aged between 6 and 18 years. Participants were categorized into children (6–9 years) and adolescents (10–18 years). Pediatric and adolescent patients were selected from among subjects with LDL-C ≥ 130 mg/dL and diagnosed with heterozygous familial hypercholesterolemia (HeFH) based on the presence of mutations in the LDL receptor (LDL-R) gene. Patients with HeFH who were receiving regular atorvastatin therapy were included in the study. Results There were no notable differences in catalase and paraoxonase (PON1) activities among the groups. However, the patient group displayed substantially higher levels of malondialdehyde (MDA) ( P = 0.0108 ) and superoxide dismutase (SOD) activity ( P = 0.0103 ). Compared to the healthy control group, serum chitotriosidase (CHITO) activity ( P = 0.037 ) and chitinase 3-like protein 1 (YKL-40) levels ( P = 0.0027 ) were significantly elevated in the patient group. Furthermore, the carotid intima-media thickness (CIMT) measurements of the patient group were significantly greater than those of the healthy group (** P < 0.0001****). The patient group exhibited significantly elevated levels of 5,6-α-epoxycholesterol, Cholestane-3β,5α,6β-triol (C-triol), and 7-ketocholesterol (7-KC), whereas 27-hydroxycholesterol (27-OHC) was significantly more abundant in the healthy group. On the other hand, while 27-OHC/Total cholesterol (Total-C) levels were significantly higher in healthy individuals, the C-Triol/Total-C ratio was significantly higher in patients. No significant differences were found between the groups in terms of 7-KC/Total-C and 5,6-α-epoxycholesterol/Total-C levels. Conclusion This study highlights the key roles of oxysterols, oxidative stress, and macrophage activation in the development of atherosclerosis in pediatric and adolescent patients with FH. Elevated C-Triol levels in FH patients, alongside increased CIMT, point to early vascular changes despite atorvastatin therapy. In contrast, higher 27-OHC levels in healthy controls suggest differential oxysterol ...

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Macrophages in inflammatory skin diseases and skin tumors

Liu,

Zhang,

Zuo

2024

Front. Immunol.

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Macrophages, as specialized, long-lasting phagocytic cells of the innate immune system, have garnered increasing attention due to their wide distribution and various functions. The skin, being the largest immune organ in the human body, presents an intriguing landscape for macrophage research, particularly regarding their roles in inflammatory skin diseases and skin tumors. In this review, we compile the latest research on macrophages in conditions such as atopic dermatitis, psoriasis, systemic sclerosis, systemic lupus erythematosus, rosacea, bullous pemphigoid, melanoma and cutaneous T-cell lymphoma. We aim to contribute to illustrating the pathogenesis and potential new therapies for inflammatory skin diseases and skin tumors from the perspective of macrophages.

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A novel marker of systemic inflammation in psoriasis and related comorbidities: chitotriosidase

Cited by 4 publications

References 22 publications

Chitotriosidase: Providing confirmation of cutaneous sarcoidosis when angiotensin converting enzyme fails

Chitotriosidase: Providing confirmation of cutaneous sarcoidosis when angiotensin converting enzyme fails

Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia

Macrophages in inflammatory skin diseases and skin tumors

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