A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback

Romero, César A; Carretero, Oscar A.

doi:10.1007/s11906-019-0911-5

Cited by 8 publications

(3 citation statements)

References 52 publications

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“…The autoregulation of RBF is mediated primarily by two mechanisms, the fast myogenic response and the slower macula densa (MD) tubulo-glomerular feedback (TGF). Two other autoregulatory mechanisms have been proposed, one that operates at a low frequency [ 6 ] and one that involves crosstalk between the connecting tubule and the afferent arteriole [ 7 ], but their contributions appear smaller and they remain poorly understood [ 8 ]. Modeling studies have significantly expanded our understanding of these intrinsic regulatory mechanisms, including their relative contributions and interactions and how they are affected by specific pathological conditions [ 9 , 10 ].…”

Section: Renal Blood Flowmentioning

confidence: 99%

Renal blood flow and oxygenation

Edwards

Kurtcuoglu

2022

Pflugers Arch - Eur J Physiol

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Our kidneys receive about one-fifth of the cardiac output at rest and have a low oxygen extraction ratio, but may sustain, under some conditions, hypoxic injuries that might lead to chronic kidney disease. This is due to large regional variations in renal blood flow and oxygenation, which are the prerequisite for some and the consequence of other kidney functions. The concurrent operation of these functions is reliant on a multitude of neuro-hormonal signaling cascades and feedback loops that also include the regulation of renal blood flow and tissue oxygenation. Starting with open questions on regulatory processes and disease mechanisms, we review herein the literature on renal blood flow and oxygenation. We assess the current understanding of renal blood flow regulation, reasons for disparities in oxygen delivery and consumption, and the consequences of disbalance between O2 delivery, consumption, and removal. We further consider methods for measuring and computing blood velocity, flow rate, oxygen partial pressure, and related parameters and point out how limitations of these methods constitute important hurdles in this area of research. We conclude that to obtain an integrated understanding of the relation between renal function and renal blood flow and oxygenation, combined experimental and computational modeling studies will be needed.

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Section: Renal Blood Flowmentioning

confidence: 99%

Renal blood flow and oxygenation

Edwards

Kurtcuoglu

2022

Pflugers Arch - Eur J Physiol

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“…CTGF has recently been suggested as a novel mechanism for renal microcirculatory regulation that involves sodium handling in the connecting tubules (CNT) [ 28 ]. It has been shown that a high sodium content in CNT could cause Af-Art vasodilation initiated by activation of epithelial Na + channel in a distal nephrons [ 16 , 29 ].…”

Section: Autoregulation Of the Kidney Microcirculationmentioning

confidence: 99%

Kidney Microcirculation as a Target for Innovative Therapies in AKI

Ergin

Akın

İnce

2021

JCM

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Acute kidney injury (AKI) is a serious multifactorial conditions accompanied by the loss of function and damage. The renal microcirculation plays a crucial role in maintaining the kidney’s functional and structural integrity for oxygen and nutrient supply and waste product removal. However, alterations in microcirculation and oxygenation due to renal perfusion defects, hypoxia, renal tubular, and endothelial damage can result in AKI and the loss of renal function regardless of systemic hemodynamic changes. The unique structural organization of the renal microvasculature and the presence of autoregulation make it difficult to understand the mechanisms and the occurrence of AKI following disorders such as septic, hemorrhagic, or cardiogenic shock; ischemia/reperfusion; chronic heart failure; cardiorenal syndrome; and hemodilution. In this review, we describe the organization of microcirculation, autoregulation, and pathophysiological alterations leading to AKI. We then suggest innovative therapies focused on the protection of the renal microcirculation and oxygenation to prevent AKI.

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“…Los derivados del ácido araquidónico inducen una respuesta vasodilatadora en el endotelio al bloquear la ON sintasa y la ciclooxigenasa (Cox). Por lo cual, el ON junto al ácido araquidónico participan en la modulación de la actividad del mecanismo de RTG (Burke y cols., 2014;Ren y cols., 2009;Romero y Carretero, 2019b, 2019aH. Wang y cols., 2010).…”

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Factores de predisposición al daño renal agudo producido por los antiinflamatorios no esteroideos

Thomas¹

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Quiero agradecer infinitamente a Dios por todo lo que hace en mí. La realización de esta tesis doctoral no hubiera sido posible sin su ayuda y sin la intervención de las muchas personas que Él ha puesto en mi camino, las cuales han sido de mucho apoyo.A mi querida esposa Ángela, por el gran amor mostrado hacia mí, por animarme a lograr cada una de mis metas, por su apreciado cuidado y constante interés en mis proyectos. Quiero agradecer a mi querida abuela Rosa, que, aunque ya no está presente, junto a mi madre Bienvenida, siempre apostaron por mí apoyándome en todo. Así mismo, quiero agradecer a mis tíos, los cuales muchos de ellos se han comportado como padres durante muchos años, mostrando un cuidado especial por mí. Agradezco también a mis hermanas Eilyn y Niovel, que junto a mi padre Hipólito, han estado presentes estimulándome a seguir adelante.A los demás familiares y por supuesto a mis hermanos de la iglesia evangélica Templo Bíblico Bayona y de la iglesia Calle Volta por el cuidado e interés mostrado; cuando se acercaban para saber cómo estaba y por mostrar su más sincera ayuda en cada una de las esferas de mí vida.Mi especial agradecimiento al Dr. Francisco J. López Hernández, al Dr. Carlos Martínez Salgado y a la Dra. Isabel Fuentes Calvo, por haberme permitido formar parte de este grupo y participar en este proyecto de investigación. Gracias por la cercanía y amistad brindada; por sus sabios consejos, sugerencias y orientaciones durante este tiempo; quienes con tanto acierto y de una forma tan amena me han dirigido, porque sin su ayuda no hubiera logrado avanzar durante estos años, ni finalizar esta tesis con la grata experiencia de haber contado con excelentes directores.

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A Novel Mechanism of Renal Microcirculation Regulation: Connecting Tubule-Glomerular Feedback

Cited by 8 publications

References 52 publications

Renal blood flow and oxygenation

Renal blood flow and oxygenation

Kidney Microcirculation as a Target for Innovative Therapies in AKI

Factores de predisposición al daño renal agudo producido por los antiinflamatorios no esteroideos

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