A Novel Member of
            <i>Chitinophagaceae</i>
            Isolated from a Human Peritoneal Tumor

Lo, Alexander S; Merrell, D. Scott; Lei, Haiyan; Sardi, Armando; McAvoy, Thomas J.; Testerman, Traci L.

doi:10.1128/genomea.01297-15

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…Subsequent whole-genome sequencing revealed that PMP191F closely resembled Niastella, Chitinophaga, and Flavitalea genera with a definite identity. It was hypothesized that this isolate represents a novel bacteria species that might bind MUC2 and potentially influence PMP progression [21]. However, as this is based on a single isolate, it naturally requires further validation and deeper analysis.…”

Section: Bacteria and Pmpmentioning

confidence: 99%

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review

et al. 2022

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Pseudomyxoma peritonei (PMP) is a rare clinical syndrome. It originates from neoplasms of the appendix and leads to the formation of peritoneal implants and the accumulation of mucinous ascites. PMP represents a spectrum of low to high-grade disease. Despite aggressive management, many PMP patients recur, leading to debilitating symptoms and few treatment options. Therefore, scientists have continued to look for ways to improve treatment and further understand disease pathogenesis. Microorganisms were previously hypothesized to play a role in PMP progression and development. Hence, antibacterial treatment was suggested by some authors, but the data were limited. In this paper, we review the current data on the role of bacteria in PMP, discuss the significance, and suggest possible solutions to the inherent challenges in these studies. Given the limitations of the discussed studies, we remain skeptical about introducing novel antibacterial treatment into clinical practice at this time; however, the available data are valuable and indicate that more research into the molecular mechanisms of PMP is needed.

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Section: Bacteria and Pmpmentioning

confidence: 99%

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review

et al. 2022

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“…Chitinophagaceae (phylum Bacteroidetes) comprises a ubiquitous bacterial family that was recently described in soil (Bailey, Fansler, Stegen, & McCue, 2013;Lv, Wang, Chen, You, & Qiu, 2016), freshwater (Leite et al, 2016;Siddiqi & Im, 2016), a hypersaline lake (Vavourakis et al, 2016), hot springs (Hanada, Tamaki, Nakamura, & Kamagata, 2014), maize roots (Gao et al, 2016) and human tumours (Lo et al, 2015). This is a clade with strong taxonomic support, even though few genomes have been fully sequenced to date.…”

Section: Introductionmentioning

confidence: 99%

Single‐cell sequencing unveils the lifestyle and CRISPR‐based population history of Hydrotalea sp. in acid mine drainage

et al. 2017

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Acid mine drainage (AMD) is characterized by an acid and metal-rich run-off that originates from mining systems. Despite having been studied for many decades, much remains unknown about the microbial community dynamics in AMD sites, especially during their early development, when the acidity is moderate. Here, we describe draft genome assemblies from single cells retrieved from an early-stage AMD sample. These cells belong to the genus Hydrotalea and are closely related to Hydrotalea flava. The phylogeny and average nucleotide identity analysis suggest that all single amplified genomes (SAGs) form two clades that may represent different strains. These cells have the genomic potential for denitrification, copper and other metal resistance. Two coexisting CRISPR-Cas loci were recovered across SAGs, and we observed heterogeneity in the population with regard to the spacer sequences, together with the loss of trailer-end spacers. Our results suggest that the genomes of Hydrotalea sp. strains studied here are adjusting to a quickly changing selective pressure at the microhabitat scale, and an important form of this selective pressure is infection by foreign DNA.

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“… Niastella has been isolated from soil, and there are few studies regarding the role of Niastella in disease. A unique microorganism named PMP191F, with similarities to Niastella , has been isolated from peritoneal tumours [38, 39]. The genus Actinosynnema is a culture source of ansamitocin P-3 against tumours [40].…”

Section: Discussionmentioning

confidence: 99%

16S rDNA analysis of osteoporotic rats treated with osteoking

Sun

Zhang

Chen

et al. 2022

Journal of Medical Microbiology

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Introduction. Osteoporosis (OP) is characterized by microstructural degeneration of bone tissue, low bone mass, bone fragility and even brittle fracture (osteoporotic fracture, OPF). OP and OPF are common and there are many disadvantages to the current medications for OP/OPF. Osteoking is a traditional Chinese medicine (TCM) originating from the Yi nationality (Yunnan, China) that has been used to treat bone diseases for decades. Hypothesis/Gap Statement. This study will reveal the changes in the intestinal microbiota of OP rats after 70 days of osteoking treatment. Method. With duplication of sham and OP rats, eight groups were established, with six rats in each group. The intestinal microbiotas were analysed by 16S rDNA sequencing. Results. The results showed that osteoking changed the intestinal microbiota of sham rats and OP rats. The mechanism by which osteoking improves OP is related to the functions of the intestinal microbiota. After 70 days of treatment with osteoking, the contents of Pseudonocardia, Pedomicrobium, Variovorax, Niastella and Actinosynnema were decreased in OP rats. The functions of the above intestinal microbiota related to iron metabolism affected calcifediol and 25(OH)D, and measuring these bone metabolic indicators is required for further study. Conclusion. Osteoking changes the intestinal microbiota to improve OP, and further study which reveals these intestinal microbiota and mechanism is needed.

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A Novel Member of Chitinophagaceae Isolated from a Human Peritoneal Tumor

Cited by 7 publications

References 6 publications

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review

The Role of Microorganisms in Appendiceal Pseudomyxoma Peritonei: A Review

Single‐cell sequencing unveils the lifestyle and CRISPR‐based population history of Hydrotalea sp. in acid mine drainage

16S rDNA analysis of osteoporotic rats treated with osteoking

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