A Novel Membrane Sensor for Histamine H1-Receptor Antagonist “Fexofenadine”

Abstract

The construction and general performance of thirteen new polymeric membrane sensors for the determination of fexofenadine hydrochloride based on its ion exchange with reineckate, tetraphenylborate and tetraiodomercurate have been studied. The effects of membrane composition, type of plasticizer, pH value of sample solution and concentration of the analyte in the sensor internal solution have been thoroughly investigated. The novel sensor based on reineckate exchanger shows a stable, potentiometric response for fexofenadine in the concentration range of 1 × 10 -2 -2.5 × 10 -6 M at 25˚C that is independent of pH in the range of 2.0 -4.5. The sensor possesses a Nernstian cationic slope of 62.3 ± 0.7 mV/concentration decade and a lower detection limit of 1.3 × 10 -6 M with a fast response time of 20 -40 s. Selectivity coefficients for a number of interfering ions and excipients relative to fexofenadine were investigated. There is negligible interference from almost all studied cations, anions, and pharmaceutical excipients, however, citrizine that has a structure homologous to that of fexofenadine was found to interfere. The determination of fexofenadine in aqueous solution shows an average recovery of 99.83% with a mean relative standard deviation (RSD) of 0.5%. Direct potentiometric determination of fexofenadine in tablets gave results that compare favorably with those obtained by standard spectrophotometric methods. Potentiometric titration of fexofenadine with phosphomolybdic acid as a titrant has been monitored with the proposed sensor as an end point indicator electrode.

Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

“…The effect of volume of aqueous phase was studied by using different volumes of aqueous phase (including drug, AZS, and HCl) such as 15,20,25,30, and 35 mL and extracting with 10 mL of dichloromethane. The use of 25 mL of aqueous phase was found to be sufficient to achieve maximum absorbance of measured species and minimum absorbance of reagent blank and hence an aqueous phase of 25 mL was fixed throughout.…”

“…Quantification of FFH has been achieved by high performance liquid chromatography (HPLC) [4][5][6][7][8][9][10][11][12][13], spectrofluorimetry [14], capillary electrophoresis [15], cyclic voltammetry [16], and UV spectrophotometry [17][18][19]. Direct potentiometric and potentiometric titrations methods employing polymeric membrane sensors were developed by Abbas et al; the titrimetric method involved potentiometric titration of the drug with phosphomolybdic acid, and membrane sensors were used for end-point detection [20]. Some of these methods have sufficient sensitivity to determine lower concentrations of the drug.…”

Flow injection potentiometric determination of Chlorphenoxamine Hydrochloride

“…Varying the composition of internal reference solution could considerably improve the linear range and limit of detection [27,28], therefore the response of the electrode in relation to the variation of internal solution was investigated using the optimum membrane composition. Three different concentrations of Ch-HCl (1.0 9 10 -3 , 5.0 9 10 -4 and 1.0 9 10 -4 mol L -1 ) with 1 9 10 -1 mol L -1 NaCl in filling solution were investigated.…”

Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

“…The drug is official in BP [3] and USP [4], which describe HPLC methods for the assay of fexofenadine hydrochloride. Several analytical methods for the determination of fexofenadine hydrochloride in pharmaceutical formulations have been reported including high performance liquid chromatography [5][6][7][8], spectrophotometry [8][9][10][11][12], conductometry [13], extractive spectrophotometry with bromothymol blue, bromocresol green, bromocresol purple and bromophenol blue [13,14], spectrofluorometry [15], potentiometry [16] and capillary electrophoresis [17,18]. Fexofenadine hydrochloride has been determined in combination with other drugs using high performance liquid chromatography [19][20][21][22][23], high performance thin layer chromatography [24] and spectrophotometry [25][26][27] in combined dosage forms.…”