A novel method for assessing patients with schizophrenia and their first‐degree relatives by increasing cognitive load of visuo‐spatial working memory

Soni, S. K.; Muthukrishnan, Suriya Prakash; Sood, Mamta; Kaur, Simran; Mehta, Nishank; Sharma, Ratna

doi:10.1111/appy.12333

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…The evaluation of spatial memory is dependent on several elements of working memory and in patients with SCZ, the deterioration of this cognitive ability may reflect the disorganization of thought in these subjects (Soni et al , 2018). Atrophied communication has been found, particularly between the temporal and frontal brain regions, linked to the inability to implement strategies necessary for spatial memory (cognitive mapping), so it is common for these subjects to show poor performance during evaluations such as the virtual-reality navigation task (Wilkins et al , 2019).…”

Section: Spatial Working Memory and Ket: Morris Water Maze T And Y-mazesmentioning

confidence: 99%

Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia

Santiago

Roldán

Picazo

2022

Behavioural Pharmacology

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Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of positive symptoms (hallucinations, delusions, and disorganization of thought and language), negative symptoms (abulia, alogia, and affective flattening), and cognitive impairment (attention deficit, impaired declarative memory, and deficits in social cognition). Dopaminergic hyperactivity seems to explain the positive symptoms, but it does not completely clarify the appearance of negative and cognitive clinical manifestations. Preclinical data have demonstrated that acute and subchronic treatment with NMDA receptor antagonists such as ketamine (KET) represents a useful model that resembles the schizophrenia symptomatology, including cognitive impairment. This latter has been explained as a hypofunction of NMDA receptors located on the GABA parvalbumin-positive interneurons (near to the cortical pyramidal cells), thus generating an imbalance between the inhibitory and excitatory activity in the corticomesolimbic circuits. The use of behavioral models to explore alterations in different domains of memory is vital to learn more about the neurobiological changes that underlie schizophrenia. Thus, to better understand the neurophysiological mechanisms involved in cognitive impairment related to schizophrenia, the purpose of this review is to analyze the most recent findings regarding the effect of KET administration on these processes.

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Section: Spatial Working Memory and Ket: Morris Water Maze T And Y-mazesmentioning

confidence: 99%

Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia

Santiago

Roldán

Picazo

2022

Behavioural Pharmacology

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“…Schizophrenia is a clinically heterogeneous disease with patients showing a wide range of symptoms and deficits (Chou et al, 2017;Soni et al, 2018;Yang et al, 2017) that lead to a decreased quality of life (Cheng et al, 2019;Choo, Chew, Ho, & Ho, 2018) and increased stigma (Zhang et al, 2019). It has a complicated etiology that is influenced by both genetic and environmental factors, including a family history of psychiatric disorders, the polygenic risk score, and parental socioeconomic status (Agerbo et al, 2015;Kakela et al, 2017;Mortensen, Pedersen, & Pedersen, 2010).…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of familial schizophrenia

Liu

Zhou

Xiong

et al. 2020

Asia-Pacific Psychiatry

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Introduction: A family history of psychiatric disorders is one of the strongest risk factors for schizophrenia. The characteristics of patients with a family history of psychiatric disorders have not been systematically evaluated.Methods: This multicenter study (26 centers, 2425 cases) was performed in a Chinese population to examine the sociodemographic and clinical characteristics of schizophrenia patients with a family history of psychotic disorders in comparison with those of patients with sporadic schizophrenia.Results: Nineteen percent of patients had a family history of mental disease. Multiple logistic regression analysis revealed that ≥4 hospitalizations (OR = 1.78, P = .004), tobacco dependence (OR = 1.48, P = .006), alcohol dependence (OR = 1.74, P = .013), and physical illness (OR = 1.89, P = .001) were independently and significantly associated with a family history of mental disease. Conclusion:Patients with a family history of mental disorders present different demographics and clinical features than patients without a family history of psychiatric disorders.

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Pre-trial and pre-response EEG microstates in schizophrenia: An endophenotypic marker

Soni

Muthukrishnan

Samanchi

et al. 2019

Behavioural Brain Research

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A novel method for assessing patients with schizophrenia and their first‐degree relatives by increasing cognitive load of visuo‐spatial working memory

Abstract: Visuo-spatial working memory was impaired in schizophrenia with increasing cognitive load with no difference in search time between the groups.

Cited by 5 publications

References 33 publications

Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia

Ketamine as a pharmacological tool for the preclinical study of memory deficit in schizophrenia

Clinical characteristics of familial schizophrenia

Pre-trial and pre-response EEG microstates in schizophrenia: An endophenotypic marker

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