A novel method for evaluating enhancement using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid in the hepatobiliary phase of magnetic resonance imaging

Takatsu, Yasuo; Kobayashi, Satoshi; Miyati, Tosiaki; Shiozaki, Toshiki

doi:10.1016/j.clinimag.2016.07.001

Cited by 15 publications

(15 citation statements)

References 20 publications

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“…These results suggested that LPC might be a more useful alternative imaging biomarker for evaluating liver function than LSC and the liver parenchyma SI. Takatsu found that LPC could be used as a substitute for LSC for a simple assessment of the degree of hepatic contrast enhancement [25], which is consistent with our research. In addition, the authors also believed that LPC can be especially useful in cases of splenectomy and Gamna-Gandy bodies [25].…”

Section: Discussionsupporting

confidence: 91%

“…Takatsu found that LPC could be used as a substitute for LSC for a simple assessment of the degree of hepatic contrast enhancement [25], which is consistent with our research. In addition, the authors also believed that LPC can be especially useful in cases of splenectomy and Gamna-Gandy bodies [25]. However, we thought this conclusion needed further veri cation because of the small number of patients who underwent splenectomy (n = 6) and those with Gamna-Gandy bodies (n = 7), and these patients were Child-Pugh class B.…”

Section: Discussionsupporting

confidence: 91%

“…Unlike that of enhanced CT, the signal intensity of enhanced MRI has a nonlinear relationship with the concentration of contrast agent, and most studies have used a reference tissue (spleen) to correct the liver signal. As we have seen, only one study has examined the relationship between LPC and LSC [25].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

Ming

Zhang

Zhao

et al. 2020

Preprint

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Background: Previous studies used the signal intensity (SI) to reflect liver function. However, there are still few studies on the assessment of liver function via the portal vein, and no study has pointed out that in terms of SI (liver, spleen, portal vein), which one can better reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can be used to evaluate liver function in patients with cirrhosis and determine which parameter is best.Methods: A total of 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who underwent Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the SI of the liver parenchyma, portal vein, and spleen and liver-to-portal vein (LPC), liver-to-spleen (LSC), and portal vein-to-spleen (PSC) contrast ratios on the 15-min hepatobiliary phase images were performed among groups, and the correlations among liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI date were also quantitatively analyzed.Results: Significant differences were observed in the SI of the liver parenchyma, LPC and LSC among groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The SI of the portal vein constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but there were no differences among groups in portal vein signal and PSC (P > 0.05). LPC had a stronger correlation with Child-Pugh score and MELD score than LSC and liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05).Conclusion: Liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers for assessing liver function, while the portal vein signal and PSC could not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than liver parenchyma SI and LSC.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

Ming

Zhang

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…These results suggest that LPC may be a more useful alternative imaging biomarker to evaluate liver function than LSC and the liver parenchyma SI. Takatsu found that LPC could be used as a substitute for LSC for a simple assessment of the degree of hepatic contrast enhancement [25], consistent with our ndings. Additionally, the authors believed that LPC could be particularly useful in cases of splenectomy and Gamna-Gandy bodies [25].…”

Section: Discussionsupporting

confidence: 91%

“…Takatsu found that LPC could be used as a substitute for LSC for a simple assessment of the degree of hepatic contrast enhancement [25], consistent with our ndings. Additionally, the authors believed that LPC could be particularly useful in cases of splenectomy and Gamna-Gandy bodies [25]. However, we thought this conclusion needed further veri cation because of the small number of patients who had undergone splenectomy (n = 6) and those with Gamna-Gandy bodies (n = 7), and all of these patients had Child-Pugh class B disease.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

Yang

Zhang

Zhao

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Previous studies have used signal intensity (SI) to reflect liver function. However, few studies have evaluated liver function via the portal vein. Regarding the SI of the liver, spleen, and portal vein, no study has indicated which can best reflect liver function. Therefore, the aim of this study is to investigate whether these parameters can evaluate liver function in patients with cirrhosis and determine which is the best parameter.Methods: 120 patients with normal livers (n = 41) or Child–Pugh class A (n = 50), B (n = 21) or C (n = 8) disease who had undergone Gd-EOB-DTPA-enhanced MRI were retrospectively reviewed. Comparisons of the MRI data (liver parenchyma SI, portal vein SI, and spleen SI and liver-to-portal vein contrast ratio (LPC), liver-to-spleen contrast ratio (LSC), and portal vein-to-spleen contrast ratio (PSC)) in the 15-min hepatobiliary phase images were performed among the groups, and the correlations among the liver function parameters (total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, albumin, creatinine, platelet count, prothrombin time and international normalized ratio), liver function scores and MRI data were also quantitatively analysed.Results: Significant differences were observed in the liver parenchyma SI, LPC and LSC among the groups. These values all decreased gradually from normal livers to Child–Pugh class C cirrhotic livers (P < 0.001). The portal vein SI constantly and slightly increased from normal livers to Child–Pugh class C cirrhotic livers, but no differences were found among the groups in the portal vein SI and PSC (P > 0.05). LPC showed a stronger correlation with the Child–Pugh score and MELD score than LSC and the liver parenchyma SI. The order of the AUCs of these parameters, from largest to smallest, was as follows: LPC, LSC, and liver parenchyma SI (P > 0.05).Conclusion: The liver parenchyma SI, LSC and LPC may be used as alternative imaging biomarkers to assess liver function, while the portal vein SI and PSC do not reflect liver function. Furthermore, LPC values can more effectively distinguish severity among patients with cirrhosis than the liver parenchyma SI and LSC.

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Visualization Score of Gadoxetic Acid‐Enhanced Magnetic Resonance Imaging: The Effect on the Diagnostic Accuracy for Hepatocellular Carcinoma

Heo

Choi

Hong

et al. 2022

Magnetic Resonance Imaging

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Background The visualization score of hepatobiliary‐phase (HBP) images has been introduced as an image quality index for gadoxetic acid‐enhanced MRI. It may be associated with hepatic function and could have an implication on the diagnostic accuracy for hepatocellular carcinoma (HCC). Purpose To investigate the association between the visualization score of gadoxetic acid‐enhanced MRI and clinical factors and to evaluate its effect on the diagnostic accuracy for HCC ≤ 3.0 cm. Study type Retrospective. Population A total of 493 focal lesions from 397 patients. Field strength/Sequence A 5‐T or 3.0 ‐T with pre/postcontrast T1‐weighted 3D gradient echo sequence, and T2‐weighted fast spin‐echo sequence Assessment Child‐Pugh classification and albumin‐bilirubin (ALBI) score were assessed. Three readers evaluated the visualization score of each MRI examination (A, no or minimal; B, moderate; and C, severe limitations), and major features (arterial‐phase hyperenhancement, washout, enhancing capsule, threshold growth) and ancillary features of each focal lesion. Statistical Tests Univariable and multivariable logistic regression analyses were performed to determine significant clinical factors associated with a suboptimal visualization score (B or C). Generalized estimating equations were used to compare the sensitivity and specificity for diagnosing HCC between the two group (visualization score A vs. B or C). A P value < 0.05 was considered statistically significant. Results Of the 397 MRI examinations, the incidence of suboptimal visualization score was 13%. A suboptimal visualization score was significantly associated with Child‐Pugh classification B or C (adjusted odds ratio [OR] = 15.2) and ALBI grade 2 or 3 (OR = 4.7). Compared with the visualization score A group, the suboptimal visualization score group showed significantly lower sensitivity (56.8% vs. 75.2%) and less frequent washout in HCC (62.2% vs. 84.0%). Data Conclusion The visualization score on gadoxetic acid‐enhanced MRI can be an important image quality index and the diagnostic accuracy for HCC ≤ 3.0 cm may not be sufficient in the suboptimal visualization score group. Level of Evidence 3 Technical Efficacy Stage 3

show abstract

A novel method for evaluating enhancement using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid in the hepatobiliary phase of magnetic resonance imaging

Cited by 15 publications

References 20 publications

Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

Evaluation of the liver function by the liver parenchyma, spleen and portal vein signal intensity during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

Evaluation of liver function using liver parenchyma, spleen and portal vein signal intensities during the hepatobiliary phase in Gd-EOB-DTPA-enhanced MRI

Visualization Score of Gadoxetic Acid‐Enhanced Magnetic Resonance Imaging: The Effect on the Diagnostic Accuracy for Hepatocellular Carcinoma

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