A novel method for generation of amphiphilic PDMS particles by selective modification

Zhao, Libo; Li, Sizhe; Hu, Hao; Guo, Zhi-Xiao; Guo, Feng; Zhang, Nangang; Ji, Xinghu; Liu, Wei; Liu, Kan; Guo, Shishang; Zhao, Xingzhong

doi:10.1007/s10404-010-0673-5

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…Also, several commercially available polymers have been used for the precipitation of particles, mostly in the micrometer size range. ,− The main drawbacks of such methods are poor colloidal stability, excessive use of organic solvent, and limited control on particle size . The amphiphilic block copolymers can undergo self-assembly during precipitation, − which results in stable particle formation in solution. Such particles were used to encapsulate dyes, − drugs, ,− and nanomaterials. , …”

Section: Introductionmentioning

confidence: 99%

Controlled Dye Aggregation in Sodium Dodecylsulfate-Stabilized Poly(methylmethacrylate) Nanoparticles as Fluorescent Imaging Probes

2018

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Polymer nanoparticles are used extensively in biomedical applications. Poly(methylmethacrylate) (PMMA) nanoparticles obtained via nanoprecipitation were unstable and flocculate or precipitate from solution within a few hours. A simple method to improve the stability of the particles using surfactants at low concentrations was carried out to produce PMMA nanoparticles with long-term stability in water (>6 months). The increased stability was attributed to the incorporation of surfactants inside the polymer particles during nanoprecipitation. The same methodology was also adopted to encapsulate a highly fluorescent hydrophobic perylene tetraester inside the polymer nanoparticles with good stability in water. Because of the presence of the anionic sodium dodecyl sulfate, the particles showed a negative zeta potential of −34.7 mV and an average size of 150 nm. Similarly, the dye-encapsulated polymer nanoparticles showed a zeta potential of −35.1 mV and an average particle size of 180 nm. By varying the concentration of encapsulated dyes inside the polymer nanoparticles, dye aggregation could be controlled, and the fluorescence profiles of the nanoparticles were altered. To understand the uptake and toxicity of the polymer nanoparticles, baby hamster kidney cells were chosen as a model system. The polymer nanoparticles were taken up by the cells within 3 h and were nontoxic at concentrations as high as 100 ppm. The confocal micrographs of the cells revealed localized fluorescence from the polymer nanoparticles around the nucleus in the cytoplasm without the penetration of the nuclear envelope.

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Section: Introductionmentioning

confidence: 99%

Controlled Dye Aggregation in Sodium Dodecylsulfate-Stabilized Poly(methylmethacrylate) Nanoparticles as Fluorescent Imaging Probes

2018

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“…In addition, the mechanical properties 10 , 11 of the PDMS can be easily tuned by changing the ratio of the two-component PDMS precursor 8 . Despite the potential to tune the stiffness of PDMS microparticles, this parameter remains unvaried for solid PDMS 6 , 8 , 12 , gas-filled 5 , 13 , 14 and liquid-filled microcapsules 7 , 9 .…”

Section: Introductionmentioning

confidence: 99%

Flow of Tunable Elastic Microcapsules through Constrictions

Nascimento

Avendaño

Mehl

et al. 2017

Sci Rep

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We design and fabricate elastically tunable monodisperse microcapsules using microfluidics and cross-linkable polydimethylsiloxane (PDMS). The overall stiffness of the microcapsules is governed by both the thickness and cross-link ratio of the polymer shell. Flowing suspensions of microcapsules through constricted spaces leads to transient blockage of fluid flow, thus altering the flow behavior. The ability to tune microcapsule mechanical properties enables the design of elastic microcapsules that can be tailored for desired flow behavior in a broad range of applications such as oil recovery, reactor feeding, red blood cell flow and chemical targeted delivery.

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“…15 Microfluidics, particularly flow focusing principle, has proven to be an extraordinary working platform to produce fluid microentities. A co-flowing method was used to generate amphiphilic PDMS particles with hundreds of microns in size by Zhao et al 16 Jiang et al 15 have proposed a flow-focusing technique where a PDMS precursor was dispersed into microdroplets within an aqueous continuous phase. By using this method, they were able to produce PDMS microbeads with an average dimension of 80 lm to use them as discrete oxygen sensors.…”

Section: Introductionmentioning

confidence: 99%

Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications

et al. 2016

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Polydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering. V C 2016 AIP Publishing LLC.

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A novel method for generation of amphiphilic PDMS particles by selective modification

Cited by 11 publications

References 16 publications

Controlled Dye Aggregation in Sodium Dodecylsulfate-Stabilized Poly(methylmethacrylate) Nanoparticles as Fluorescent Imaging Probes

Controlled Dye Aggregation in Sodium Dodecylsulfate-Stabilized Poly(methylmethacrylate) Nanoparticles as Fluorescent Imaging Probes

Flow of Tunable Elastic Microcapsules through Constrictions

Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications

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