A novel method for predicting antioxidant activity based on amino acid structure

Garrett, Andrew; Weagel, Evita G.; Martinez, Andres; Heaton, Matthew J.; Robison, Richard A.; O’Neill, Kim L.

doi:10.1016/j.foodchem.2014.02.102

Cited by 30 publications

(18 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is clear that Trp showed highest AOX activity followed by Tyr, Car, and His. Similar observations were noted by Garrett et al in his study of AOX capacity of amino acids (Garrett et al, ). The other amino acids had almost no capability to be potential AOX, and hence in this study, Trp, Tyr, and His were chosen for further investigation in their surfactant forms.…”

Section: Resultssupporting

confidence: 88%

Study of Antioxidative Properties of Some Mono Amino‐Acid‐Type and Dipeptide‐Type Surfactants

Hossain

Ohta

Yamane

et al. 2018

J Surfact & Detergents

View full text Add to dashboard Cite

Surfactants of tryptophan, tyrosine, and histidine were successfully synthesized. They were then modified to obtain dipeptide‐type surfactants with better solubility in both polar and nonpolar solvents, giving more emphasis to the development of water‐soluble amino‐acid‐type surfactants. All developed materials were designed to have functionality as antioxidants (AOX). The investigation of free radical scavenging capacity at pre‐micellar concentrations revealed greater Trolox equivalent (TE, relative scavenging capacity to Trolox) results for Trp‐type surfactants followed by Tyr‐type and His‐type. As expected, the synthesized surfactants exhibited comparable AOX properties to their parent amino acids. The AOX behavior of these surfactants was also checked in micellar concentrations, and the trend was found to be analogous: Trp‐type > Tyr‐type > His‐type surfactants. However, all of them were acting as better AOX in the micellar state than in the monomeric state. Investigating the synergistic effect found no interaction between the “amino acid–surfactant” pairs or the “surfactant–surfactant” pairs with varying ratios. They showed total AOX activity with respect to that of each material. This work opens up the door to the application of some new oil and water‐soluble amino‐acid‐type surfactants having auspicious AOX activity.

show abstract

Section: Resultssupporting

confidence: 88%

Study of Antioxidative Properties of Some Mono Amino‐Acid‐Type and Dipeptide‐Type Surfactants

Hossain

Ohta

Yamane

et al. 2018

J Surfact & Detergents

View full text Add to dashboard Cite

show abstract

“…The antioxidant activity of polyphenols is due to their ability to scavenge free radicals, donate hydrogen atoms or electron, or chelate metal cations. The fundamental of these assays relies on the fluorescence quenching of disodium fluorescein (FS) salt after exposure to AAPH (2,2-azobis(2-amidino-propane) dihydrochloride), which generates oxygen radicals (ROO•) at a constant rate [9]. ORAC assay is carried out following the method developed by Huang et al [10].…”

Section: Soxhlet Extractionmentioning

confidence: 99%

Phenolic and Flavonoid Contents of Some Plant Extracts from Tunisia Southern Landscape by Using Different Extraction Techniques: The Case of Retama reatam

Rejab¹,

Ksibi²

2019

Med Aromat Plants

View full text Add to dashboard Cite

Nowadays traditional medicine, a source of several bioactive molecules for therapeutic purposes, has become a cure for various diseases. In fact, the evaluation of plant exploitation has become progressively significant and this for their therapeutic effects of many traditional medicines may be due to the immense presence of natural antioxidants. In this respect, Retama reatam was chosen among six herbal Tunisian plants traditionally known for their therapeutic virtues, as the best source of total polyphenol content (1122,927g GEA/g extract) with an important extraction yield as ethanol is the solvent. The Soxhlet extraction always has the lowest value in total polyphenol content (164,857 GEA/g extract) for such solvent. The total flavonoid content of the different extracts is not significantly different from each other. However, the yield extraction remains higher for ethanolic extraction exceeding a value of 26.7%. Concerning antioxidant activity of Retama reatam, results suggest that supercritical CO 2 extraction can be used as an efficient alternative for pre-treatment to eliminate fatty compounds and therefore evaluating oxygen radical absorbance capacity values.

show abstract

“…20 Accumulating biochemical and clinical evidence support the phenomenon where amino acids exert its antioxidant effects to attenuate oxidative stress-mediated disorders. 21,22 Furthermore, administration of certain amino acids shown to attenuates DN in experimental animals. [23][24][25] Literature lucid with evidence showed that L-glutamine (LG) possesses potent antiulcer, antioxidant, anti-bacterial, cardioprotective, anticancer, hepatoprotective, and anti-apoptotic potential.…”

Section: Introductionmentioning

confidence: 99%

Protective effect ofL-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-β1, and collagen-1

Sadar¹,

Kaspate

Vyawahare³

2016

Renal Failure

View full text Add to dashboard Cite

Diabetic nephropathy is a serious microvascular complication and one of the main causes of endstage renal disease. L-Glutamine (LG) is naturally occurring amino acids with antidiabetic and antioxidant potential. The aim of present investigation was to evaluate the potential of LG against streptozotocin (STZ)-induced diabetic nephropathy (DN) in laboratory rats. DN was induced in male Wistar rats (200-220 g) by intraperitoneal administration of STZ (55 mg/kg). Animals were treated orally with either distilled water (10 mg/kg) or LG (250, 500, and 1000 mg/kg) or Sitagliptin (5 mg/kg). Various biochemical, molecular, and histological (hematoxylin-eosin and Masson's trichrome stain) parameters were assessed. Administration of LG (500 and 1000 mg/kg) significantly inhibited (p < .05) STZ-induced alterations in serum and urine biochemistry (urine creatinine, uric acid, albumin, and BUN). It also significantly increased creatinine clearance rate. STZ induced increase in renal oxidonitrosative stress was significantly decreased (p < .05) by LG (500 and 1000 mg/kg) treatment. Upregulated renal KIM-1, NGAL, TGF-b1, and collagen-1 mRNA expression after STZ administration was significantly inhibited (p < .05) by LG (500 and 1000 mg/ kg) treatment. Correlation analysis also revealed that antidiabetic potential of LG attenuates STZinduced elevated renal KIM-1, NGAL, TGF-b1, and collagen-1 mRNA expression. Histopathological alteration induced by STZ in renal tissue was ameliorated by LG treatment. In conclusion, results of present investigation suggest that treatment with LG ameliorated STZ-induced DN via the inhibition of oxidonitrosative stress as well as downregulation of KIM-1, NGAL, TGF-b1, and collagen-1 mRNA expressions. ARTICLE HISTORY

show abstract

A novel method for predicting antioxidant activity based on amino acid structure

Cited by 30 publications

References 24 publications

Study of Antioxidative Properties of Some Mono Amino‐Acid‐Type and Dipeptide‐Type Surfactants

Study of Antioxidative Properties of Some Mono Amino‐Acid‐Type and Dipeptide‐Type Surfactants

Phenolic and Flavonoid Contents of Some Plant Extracts from Tunisia Southern Landscape by Using Different Extraction Techniques: The Case of Retama reatam

Protective effect ofL-glutamine against diabetes-induced nephropathy in experimental animal: Role of KIM-1, NGAL, TGF-β1, and collagen-1

Contact Info

Product

Resources

About