A Novel Method for Reconstructing CT Images in GATE/GEANT4 with Application in Medical Imaging: A Complexity Analysis Approach

Gholami, N; Dehshibi, Mohammad Mahdi; Adamatzky, Andrew; Rueda-Toicen, Antonio; Zenil, Héctor; Fazlali, Mahmood; Masip, David

doi:10.2197/ipsjjip.28.161

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…For this study, not only are the electrical activities investigated, but the substrate is also irradiated with an X-ray beam from multiple angles to produce cross-sectional images of the substrate. 19 This multimodal approach enables us to identify and track the dynamics of changes in the tissue of the mycelium anatomy.…”

Section: Introductionmentioning

confidence: 99%

“…Cortisol levels in various bodily fluids can range from 4 to 70 pM. , Sweat cortisol levels have a strong correlation with salivary cortisol concentrations, and the optimal cortisol level ranges from 0.02 to 0.5 M. , Monitoring cortisol levels in bodily fluids, which can be altered by chronic stress and disease, is critical for maintaining healthy physiological conditions. For this study, not only are the electrical activities investigated, but the substrate is also irradiated with an X-ray beam from multiple angles to produce cross-sectional images of the substrate . This multimodal approach enables us to identify and track the dynamics of changes in the tissue of the mycelium anatomy.…”

Section: Introductionmentioning

confidence: 99%

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Stimulating Fungi Pleurotus ostreatus with Hydrocortisone

Dehshibi

Chiolerio

Nikolaidou

et al. 2021

ACS Biomater. Sci. Eng.

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Fungi cells can sense extracellular signals via reception, transduction, and response mechanisms, allowing them to communicate with their host and adapt to their environment. They feature effective regulatory protein expressions that enhance and regulate their response and adaptation to various triggers such as stress, hormones, physical stimuli such as light, and host factors. In our recent studies, we have shown that Pleurotus oyster fungi generate electrical potential impulses in the form of spike events in response to their exposure to environmental, mechanical, and chemical triggers, suggesting that the nature of stimuli may be deduced from the fungal electrical responses. In this study, we explored the communication protocols of fungi as reporters of human chemical secretions such as hormones, addressing whether fungi can sense human signals. We exposed Pleurotus oyster fungi to hydrocortisone, which was directly applied to the surface of a fungal-colonized hemp shavings substrate, and recorded the electrical activity of the fungi. Hydrocortisone is a medicinal hormone replacement that is similar to the natural stress hormone cortisol. Changes in cortisol levels released by the body indicate the presence of disease and can have a detrimental effect on physiological process regulation. The response of fungi to hydrocortisone was also explored further using X-rays to reveal changes in the fungi tissue, where receiving hydrocortisone by the substrate can inhibit the flow of calcium and, as a result, reduce its physiological changes. This research could open the way for future studies on adaptive fungal wearables capable of detecting human physiological states and biosensors built of living fungi.

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Section: Introductionmentioning

confidence: 99%