This study investigates the complex dynamics of retrograde condensation in condensate gas reservoirs, with a particular focus on the challenges posed by retrograde condensate pollution, which varies in condensate oil content and impacts on reservoir productivity. Numerical simulations quantify the distribution of condensate oil and the reduction in gas-phase relative permeability in reservoirs with 100.95 g/m3, 227.27 g/m3, and 893.33 g/m3 of condensate oil. Unlike previous studies, this research introduces an orthogonal experiment to establish a methodology for studying the dynamic sensitivity factors across different types of gas reservoirs and various development stages, systematically evaluating their contributions to condensate oil. The analysis reveals that reservoirs with low to moderate condensate oil content gradually experience expanding polluted regions, affecting long-term production. The maximum condensate saturation near the wellbore can reach 0.19, reducing gas-phase relative permeability by about 25.44%. In contrast, high-condensate oil reservoirs show severe early-stage retrograde condensation, with saturations up to 0.35 and a permeability damage rate reaching 73%. The orthogonal experiments identify reservoir permeability and condensate oil content as critical factors influencing production indicators. The findings provide key insights and practical recommendations for optimizing production strategies, emphasizing tailored approaches to mitigate retrograde condensation and enhance recovery, especially in high-condensate oil reservoirs, offering theoretical and practical guidance for improving reservoir management and economic returns.