A novel method for the synthesis of β-enaminones using Cu-nanoparticles as catalyst

1, 4-Addition of Terminal Alkynes to Conjugated Enones in Water Using Green Catalyst Bis[(l)prolinato-N,O]Zn—An Environmentally Benign Protocol

“…As part of our ongoing program to device the greener methodologies [35][36][37], we have tried to reveal the catalytic properties of Zn-proline complex for the synthesis of c, d-acetylenic ketones up to 85% yield under mild conditions by the coupling of enones with terminal alkynes in the presence of Zn[(L)Proline] 2 , as a catalyst and Et 3 N as an additive.…”

Ultrasound assisted synthesis of enaminones using Nickel oxide

“…Condensation of carbonyl compounds and amines mediated by acid catalysts is a simple methodology for synthesis of enamino esters. Diversified acid catalysts such as metal triflates 4 , perchlorates 5 , InBr 6 , CoCl 2 7 , silica supported mineral acid 8 , BF 3 *Et 2 O 9 , silver nanoparticles 10 , copper nanoparticles 11 , gold salts 12 and Zn(OAc) 2 13 have been used in the synthesis of β-enaminones and enamino esters. The above catalysts are either expensive or moisture sensitive or nonrecyclable or require harsh reaction conditions.…”

The Behavior of 3-Anilinoenone and N-Phenyl Cinnamamide toward Carbon Nucleophiles: Spectroscopy and X-Ray Studies Reveal Interesting New Synthesis Routes to Nicotinonitriles and Tetrahydropyridine-3- Carbonitrile

“…Due to their biological activities and pharmacological properties, pyridines and pyridones represent an important class of compounds that have been developed using functionally substituted enaminones [16][17][18][19][20][21][22]. In continuation of our interest in the synthesis of functionally substituted heteroaromatic compounds such as pyridines and pyridones, utilizing enaminones as starting materials [22][23][24][25][26][27][28][29][30][31][32][33], we report here the behavior of 3-anilinoenone and N-phenyl cinnamamide derivative toward malononitrile in the synthesis of pyridine derivatives.…”