A novel method for thermodynamic study on binding of copper ion with Alzheimer’s amyliod β peptide

Behbehani, Rezaei

doi:10.1007/s11434-009-0065-y

Cited by 7 publications

(4 citation statements)

References 32 publications

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“…In 2009 we identified more than 400 articles after searching Web of Science, PubMed, SciDir and OVID databases using ‘isothermal AND titration AND calorimetry’ or ITC or ‘Isothermal Titration Calorimetry’ search terms. These have been classified into the following categories: Pre‐2009 references cited in the text and review articles 1–43 Protein‐protein and protein‐peptide interactions 44–124 Protein/peptide‐small molecule interactions 125–218 Protein/peptide‐metal ion interactions 219–253 Protein/peptide‐nucleic acid interactions 254–273 Protein/peptide‐lipid interactions 274–292 Protein/peptide‐polysaccharide interactions 293–316 Nucleic acid‐small molecule interactions 317–348 Small molecule interactions …”

Section: Introductionmentioning

confidence: 99%

Survey of the year 2009: applications of isothermal titration calorimetry

Falconer

Collins

2010

J. Mol. Recognit.

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Isothermal titration calorimetry (ITC) is now an established and invaluable method for determining the thermodynamic constants, association constant and stoichiometry of molecular interactions in aqueous solutions. The technique has become widely used by biochemists to study protein interaction with other proteins, small molecules, metal ions, lipids, nucleic acids and carbohydrates; and nucleic acid interaction with small molecules. The drug discovery industry has utilized this approach to measure protein (or nucleic acid) interaction with drug candidates. ITC has been used to screen candidates, guide the design of potential drugs and validate the modelling used in structure-based drug design. Emerging disciplines including nanotechnology and drug delivery could benefit greatly from ITC in enhancing their understanding and control of nano-particle assembly, and drug binding and controlled release.

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Section: Introductionmentioning

confidence: 99%

Survey of the year 2009: applications of isothermal titration calorimetry

Falconer

Collins

2010

J. Mol. Recognit.

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“…It has been reported previously [15][16][17][18][19][20][21][22][23] that the heats of interactions of biopolymers with ligands (BLG-A + Cu(II) complex in this case) in the aqueous solvent (Cu(II) complex + water in the present case) mixtures can be reproduced via the following equation:…”

Section: Resultsmentioning

confidence: 71%

Thermal Study of a Newly Synthesized Cu(II) Complex Binding to Bovine β‐Lactoglobulin

Divsalar

Barzegar

Behbehani

2012

Journal of Chemistry

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We have investigated the interactions betweenβ-lactoglobulin, BLG, and new synthesized Cu(II) complex (2,2′-dibipyridine Cu(II) chloride) using isothermal titration calorimetry (ITC) methods at different temperatures of 298 and 310 K. The heats of BLG + Cu(II) interactions are reported and analyzed in terms of the extended solvation theory for calculation of binding and thermodynamic parameters of the interaction. The results suggested that binding of Cu(II) complex on BLG resulted in significant changes on the tertiary structure and conformation of protein via increasing of hydrophobicity and inducing partially unfolded structure in BLG which has a good agreement with the solvation parameters recovered by the extended solvation model suggesting destabilization of the protein.

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“…However, recent study demonstrates that soluble oligomeric A is the neurotoxic specie, but not the large amyloid deposit [28]. More studies demonstrate that A neurotoxicity depends on the interactions with copper ions, prion protein, and N-methyl-D-aspartate receptors [29,30]. Both necrotic and apoptotic processes have been found in AD brains as well as in cultured neurons after exposed to A [31,32].…”

Section: Amyloid Cascade Hypothesismentioning

confidence: 99%

Re-mention of an old neurodegenerative disease: Alzheimer’s disease

2013

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Alzheimer's disease (AD), the most common form of neuropsychiatric disorder, is characterized by neuronal degeneration and inexorably progressing dementia, especially in the elderly population. With a rapidly aging population in both developed and developing countries, AD has emerged as one of the largest growing problems worldwide. Current drugs improve the symptoms of AD, but do not have any profound intervention to delay its onset. Thus, understanding the molecular mechanisms underlying the genes tied to AD will be crucial to the development of therapeutic targets. This review will summarize the aetiology, pathology, and the evidence for the genetic components in AD, discuss the proposed amyloid cascade and the following tau hyperphosphorylation hypothesises, oxidative stress mediated neuronal cell death, as well as the function of Retromer complex during the developing of AD. Our laboratory's current research progress and the challenges that still remained will be also highlighted.

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A novel method for thermodynamic study on binding of copper ion with Alzheimer’s amyliod β peptide

Cited by 7 publications

References 32 publications

Survey of the year 2009: applications of isothermal titration calorimetry

Survey of the year 2009: applications of isothermal titration calorimetry

Thermal Study of a Newly Synthesized Cu(II) Complex Binding to Bovine β‐Lactoglobulin

Re-mention of an old neurodegenerative disease: Alzheimer’s disease

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