A Novel Method to Improve the Anticancer Activity of Natural-Based Hydroxyapatite against the Liver Cancer Cell Line HepG2 Using Mesoporous Magnesia as a Micro-Carrier

Awwad, Nasser S.; Alshahrani, Ali M.; Saleh, Kamel A.; Hamdy, Mohamed S.

doi:10.3390/molecules22121947

Cited by 16 publications

(5 citation statements)

References 42 publications

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“…Raman peaks around 275.89, 442.15, and 1313.50 cm −1 (Figure 6(a)) are associated to the characteristics peaks of MgO and are found in good agreement with the previously reported research [46][47][48][49]. Generally, these bands are not present in the bulk MgO, so it confirms nanocrystalline phases within fabricated MgO [48] which is in concurrent to XRD analysis.…”

Section: Resultssupporting

confidence: 79%

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Akram

Fakhar-e-Alam

Butt

et al. 2018

Journal of Nanomaterials

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The prime focus of this investigation is to determine which morphology of magnesium oxide (MgO) is nontoxic and accumulates in sufficient quantity to a human brain cellular/tissue model. Thus, nanostructured MgO was synthesized from a coprecipitation technique involving twin synthetic protocols and the resulting product was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), size distribution histogram, Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD) analysis and elemental composition was confirmed by EDX analysis. They were tested for selective antigen response in a human brain cancer model through biodistribution, biotoxicity via MTT assay, and tissue morphology. In addition, the MRI compatibility of MgO nanostructures and immunofluorescence studies were investigated on nanoconjugates with different immunoglobulins in the brain section. The results indicated that MgO had some degree of bindings with the antigens. These results led to the empirical modeling of MgO nanomaterials towards toxicity in cancer cells by analyzing the statistical data obtained by experiments. All these results are providing new rational strategy with the concept of MgO for MRI and PTT/PDT.

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Section: Resultssupporting

confidence: 79%

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Akram

Fakhar-e-Alam

Butt

et al. 2018

Journal of Nanomaterials

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“…According to Raman spectra of the structures, both tubes had bands at 280 and 444 cm –1 , which were assigned to lattice modes of brucite Mg(OH) 2 ( Figure S6 ). 28 , 29 However, these two peaks of the chemobrionics from the controlled injection experiment were more intense and broader than those obtained in the direct injection method. This could be related to higher amounts of magnesium involved in the formation of the structure, although the same amounts of magnesium chloride were initially injected for both experiments.…”

Section: Resultsmentioning

confidence: 77%

Development of a Controlled Injection Method Using Support Templates for the Production of Chemobrionic Materials

2022

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Chemobrionics is a research field about the well-known self-organized inorganic structures. Numerous research works have focused on controlling their growth pattern and characteristic features. In the present study, a controlled injection method is proposed to produce more regular self-assembled chemobrionics compared to the standard direct injection technique. This method involves the injection of a metal salt solution into an agarose support template filled with an anionic solution. The obtained structures were studied by scanning electron microscopy, X-ray microtomography, X-ray photoelectron spectroscopy, Raman spectroscopy, Fourier-transform IR spectroscopy, and thermogravimetric analysis. Despite the complex mechanism and chemistry underlying the self-organization phenomena, the controlled injection method enabled the generation of regular standard chemobrionic structures with high experimental reproducibility. It provided the extraction of tubular structures from the reaction vessel without breakage, thus allowing comprehensive characterization. Furthermore, the morphological, chemical, and thermal features of these structures were highly correlated with the standard chemobrionics obtained in the direct injection method. The proposed controlled injection method holds great promise for understanding and controlling the properties of chemobrionics and related structures.

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“…: 04-005-4664), visible in the expanded spectrum (inset). With the increase of MgO content, the peaks related to the MgO phase become more evident, as visible in the inset [42][43][44]. The crystalline size of the hydroxyapatite and MgO were calculated using the Debye-Scherrer equation.…”

Section: Resultsmentioning

confidence: 99%

An Eco-Friendly Process to Extract Hydroxyapatite from Sheep Bones for Regenerative Medicine: Structural, Morphologic and Electrical Studies

Gavinho,

Bozdag,

Kalkandelen

et al. 2023

JFB

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Hydroxyapatite (HA) promotes excellent bone regeneration in bone-tissue engineering, due to its similarity to bone mineral and its ability to connect to living tissues. These factors promote the osteointegration process. This process can be enhanced by the presence of electrical charges, stored in the HA. Furthermore, several ions can be added to the HA structure to promote specific biological responses, such as magnesium ions. The main objective of this work was to extract hydroxyapatite from sheep femur bones and to study their structural and electrical properties by adding different amounts of magnesium oxide. The thermal and structural characterizations were performed using DTA, XRD, density, Raman spectroscopy and FTIR analysis. The morphology was studied using SEM, and the electrical measurements were registered as a function of frequency and temperature. Results show that: (i) an increase of MgO amount indicates that the solubility of MgO is below 5%wt for heat treatments at 600 °C; (ii) the rise of MgO content increases the capacity for electrical charge storage; (iii) sheep hydroxyapatite presents itself as a natural source of hydroxyapatite, environmentally sustainable and low cost, and promising for applications in regenerative medicine.

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A Novel Method to Improve the Anticancer Activity of Natural-Based Hydroxyapatite against the Liver Cancer Cell Line HepG2 Using Mesoporous Magnesia as a Micro-Carrier

Cited by 16 publications

References 42 publications

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Magnesium Oxide in Nanodimension: Model for MRI and Multimodal Therapy

Development of a Controlled Injection Method Using Support Templates for the Production of Chemobrionic Materials

An Eco-Friendly Process to Extract Hydroxyapatite from Sheep Bones for Regenerative Medicine: Structural, Morphologic and Electrical Studies

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