A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering

Tadic, D.; Beckmann, Felix; Schwarz, Karsten; Epple, Matthias

doi:10.1016/j.biomaterials.2003.10.007

Cited by 182 publications

(141 citation statements)

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“…The modification of crystallinity, grain size, specific surface area [25,26], or the porosity content [27][28][29] are relevant physicochemical features which have been shown to help tailor resorption rates, hence improving the in vivo performance of such implants [30].Despite the various works proving increased degradation in materials with lower crystallinity, high specific surface area, decreased grain density, and a higher degree of porosity, the extent to which each parameter influences resorption remains unclear. The complexity of isolating the contribution of each of these parameters lies in the close interrelation between these factors, as changing one can potentially affect the other/s.…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

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Please cite this article as: Díez-Escudero, A., Espanol, M., Beats, S., Ginebra, M.P., In vitro degradation of calcium phosphates: effect of multiscale porosity, textural properties and composition, Acta Biomaterialia (2017), doi: http:// dx.doi.org/10. 1016/j.actbio.2017.07.033 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Introductionmentioning

confidence: 99%

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

et al. 2017

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“…Furthermore, submicron-sized HA powders are biodegraded even faster than the highly porous HA scaffolds. Other examples of bioresorbable materials include porous bioceramic scaffolds made of BCP (which is an intimate mixture of either β-TCP + HA [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] or α-TCP + HA [8][9][10][11][12]) or bone grafts (dense or porous) made of CDHA [152], TCP [411,596,597] and/or ACP [462,598]. One must stress that recently the concepts of bioactive and bioresorbable materials have converged and bioactive materials are made bioresorbable, while bioresorbable materials are made bioactive [599].…”

Section: Interaction With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

“…From the chemical point of view, the developments include synthesis of novel ion-substituted calcium orthophosphates . From the material point of view, the major research topics include nanodimensional and nanocrystalline structures [704][705][706][707][708], organic-inorganic biocomposites and hybrid biomaterials [316], fibers, whiskers and filaments [709][710][711][712][713][714][715][716][717][718][719][720][721][722], micro-and nano-sized spheres and beads [722][723][724][725][726][727][728][729][730][731][732][733][734][735][736][737], micro-and nano-sized tubes [738][739][740], porous 3D scaffolds made of ACP [462,598], TCP [432][433][434][435], HA [176,…”

Section: Bioceramic Scaffolds From Calcium Orthophosphatesmentioning

confidence: 99%

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…Hydroxyapatite (HA) is well known as the main type of calcium phosphate group due to its chemical similarity to mineral portion of bone tissue. Unique bioactivity, biocompatibility and its excellent osteoconductive capability make it a suitable ceramic material to be used as hard tissue regeneration [17,18]. Using composite of polyamide and HA for designing the intervertebral fusion cage with improved mechanical and biological properties is the main aim of this study.…”

Section: Introductionmentioning

confidence: 99%

Improving the Mechanical Properties and Apatite Formation Ability of Nano-Hydroxyapatite/Polyamide 66 Composite for Using as the Intervertebral Fusion Cage

Janghorban¹

2017

Jour. Mater. Sci. Eng. Adv. Tech.

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One of the significant challenges in designing an ideal cage is the mechanical modulus mismatch between the implant and surrounding host tissue which results in stress shielding. In this study, a nano-hydroxyapatite/polyamide 66 (n-HA/PA66) composite with mechanical properties close to spongy bone to be designed and characterized as an intervertebral fusion cage to perform spinal fusion between vertebrae in the lumbar spine. A pure natural nanohydroxyapatite (n-HA) powder was prepared by annealing bovine bone at 1000°C followed by 10h mechanical alloying. The nano-hydroxyapaptite/ polyamide 66 and polyamide 66 (PA66) cage were prepared by injection method. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectrophotometer (EDS) were used to characterize the powder and composites samples. The results showed that addition of 20% nanohydroxyapaptite results in the improvement of both mechanical and bioactivity properties. The optimum n-HA/PA66 exhibited the compressive strength and elastic modulus of 46.98 ± 2MPa and 1.53 ± 0.3GPa, respectively, which is close HAMID REZA JANGHORBAN 22 to spongy bone. In addition, observation of the superior apatite formation ability of n-HA/PA66 compared to PA66 indicates that it can be used as a bone replacement material.

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A novel method to produce hydroxyapatite objects with interconnecting porosity that avoids sintering

Cited by 182 publications

References 32 publications

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

In vitro degradation of calcium phosphates: Effect of multiscale porosity, textural properties and composition

Untitled

Improving the Mechanical Properties and Apatite Formation Ability of Nano-Hydroxyapatite/Polyamide 66 Composite for Using as the Intervertebral Fusion Cage

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